National Centre for Scientific Research has huge a campus in France and widely known as for its contribution in top notch education and research. The contribution of National Centre for Scientific Research is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc.

1. PhD student in materials science

Summary of Doctoral Project:

The ability to predict the in-service evolution and reusability of refractory materials is essential to maximize material life and reduce operational costs. The evolution in service of the thermo-chemical-mechanical properties of these materials must therefore be fully understood and predictable. Industrial-scale non-destructive testing, combined with machine learning algorithms, will be implemented to develop an accurate numerical model to assess the reusability and recyclability of refractory parts.

Last Application Date: 16 September 2022

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2. PhD student, Use of hydrogen as carbon-free energy for propulsion applications

Summary of Doctoral Project:

To reduce our impact on climate change, we must reduce our consumption of fossil fuels. The EU wants to ban fossil fuels for new cars from 2035. The use of innovative energy carriers such as hydrogen, notably from renewable electricity, will play a key role in the European “Green Deal”. Hydrogen can be used as a fuel and could reduce emissions in hard-to-control sectors, including industry and transport. In order to respect the NOx emission limits, a lowering of the flame temperature to approximately 2300 K is necessary under stoichiometric conditions, and steam dilution combustion appears to be a promising way to overcome the difficulties associated with hydrogen/air combustion. Indeed, increasing the heat capacity of the mixture and reducing the fuel and oxygen concentrations decrease the flame temperature and velocity, also limiting the transition to detonation.

Last Application Date: 16 September 2022

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3. PhD Program in Optimization of paramylon production by the microalga Euglena gracilis for use in green chemistry

Summary of Doctoral Project:

The thesis is positioned in the general framework of green chemistry, by targeting the use of microalgae for the treatment of wastewater combined with the production of biomaterials (bioplastics). The object of this thesis is in particular (i) the study and the optimization of the culture of the microalga Euglena gracilis, in particular under mixotrophic and solar growth conditions and (ii) the development of the biorefining process of the biomass produced in order to recover a fraction enriched in paramylon for use in biomaterials.

Last Application Date: September 16, 2022

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4. PhD Program in Health Ecology

Summary of Doctoral Project:

Due to their exceptional genetic characteristics, coronaviruses have the ability to cross the species barrier, infect a very wide variety of wild and domestic animals and ultimately infect humans. The recent coronavirus (SARS-CoV-1, MERS-CoV and SARS-CoV-2) epidemics highlight the imminent danger that these viruses, most of which are naturally hosted in bats, pose to health. public of human populations. In recent years, many studies have been able to highlight genomic sequences of coronaviruses in many species of bats, insectivores and frugivores, inhabiting several regions of the world and different types of ecosystems, particularly in Southeast Asia, in tropical Africa and Europe. In this context, the objective of the VIROMAM project is to draw up an inventory of the coronaviruses harbored in the bats of the Camargue, taken as a model for studying an ecosystem in the temperate regions of Mediterranean Europe, and to study the methods of their circulation in their natural environment in order to assess the risk of transmission to humans.

Last Application Date: September 16, 2022

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5. PhD Program in synthetic chemistry

Summary of Doctoral Project:

The objective of this thesis work is to develop decarboxylating reactions catalyzed by iron complexes induced by visible light, allowing the conversion of simple carboxylic acids into compounds of interest. The success of this project will be based on an original combinatorial approach allowing the selection of relevant photocatalysts (metal, ligand) via the measurement of absorbance spectra in visible light, the measurement of redox potentials and the synthesis of a molecular probe. Several decarboxylating reactions will be optimized in order to prepare attractive molecular bricks or late functionalize complex molecules. A study of the mechanism of the developed transformations will be carried out.

Last Application Date: 19 September 2022

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6. PhD Program in Understanding the role of microglia in Alzheimer’s disease

Summary of Doctoral Project:

Alzheimer’s disease is linked to brain accumulation of aggregated amyloid-β (Aβ) peptides that initiate a pathological cascade leading to tau protein aggregation and spread as well as synaptic alterations. Microglia are now established as key regulators of Alzheimer’s disease, but the nature of the interactions between microglial changes and Alzheimer’s disease pathophysiology is still unclear. These links have been mainly established in rodent models whereas microglial reactions are different between rodents and primates. The host laboratory induced Aβ/tau pathologies as well as cognitive alterations in a primate (Microcebus murinus). The working hypothesis of this thesis is that the Evaluation of microglial changes in response to induced Alzheimer’s disease will provide invaluable new insights with strong translational potential towards future therapeutic strategies against Alzheimer’s disease. The aims of the thesis are to. 1. Phenotype microglia during aging and Alzheimer’s pathology induced in a primate, including by transcriptomic approaches. 2. To assess the impact of a treatment that blocks microglia proliferation and changes the microglial inflammatory profile to an anti-inflammatory phenotype. The ability to limit microglial activation will allow assessment of the relationships between changes in microglia and the pathophysiology of Alzheimer’s disease. 

Last Application Date: 19 September 2022

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7. PhD student in materials science

Summary of Doctoral Project:

The main thermal and mechanical properties of industrial refractory materials will be studied through various experimental techniques related to the evolution of the microstructure. This work will provide an in-depth analysis in terms of variations of specific properties after use in comparison to the initial properties in order to qualify the recyclability after several thermal cycles. Expected results: determine the properties of materials at high temperature (thermal conductivity, thermal expansion, Young’s modulus, law of stress-strain behavior, fracture energy, etc.) after use in comparison with their initial state. The variations of these properties will then be implemented in finite element calculation codes within numerical models to predict their potential recyclability. The implementation of mechanical tests by non-destructive experimental techniques will be prioritized over other more conventional methods.

Last Application Date: 19 September 2022

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8. PhD student M/F Photoinduced transformation of N2 into nitrogenous precursor of polymer and fuel

Summary of Doctoral Project:

We are looking for a motivated young researcher, willing to participate in a multidisciplinary project aimed at contributing to the resolution of a fundamental problem in chemistry: How to activate inactive molecules? Today, ammonia is synthesized from nitrogen gas and hydrogen at high temperatures and pressures (Bosh-Haber process). Although effective, this process has a particularly significant impact on global warming and consumes 1 to 2% of the world’s annual energy. Our goal is to identify and tune photocatalysts absorbing in the UV-Vis region (>330 nm) involving multi-photon excitation to generate reducing equivalents that will be accumulated by a catalyst and used to reduce molecular nitrogen. Fundamental studies will aim to optimize the system by engineering the absorption cross-sections and irradiation conditions and to selectively stop the reaction at specific reaction intermediates. This can then be exploited to facilitate the isolation and purification of functional monomers that can be incorporated into more environmentally friendly polymer syntheses.

Last Application Date: September 19, 2022

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9. PhD student

Summary of Doctoral Project:

Aging has been associated with multiple diseases and is one of the most serious socio-economic problems of our time. Different types of stress signals can induce aging. The team is investigating whether aging is the result of stable changes in our transcriptome/epigenome that are induced by different types of stress experienced throughout life. The highly malleable hematopoietic system exhibits defined aging phenotypes and will be used to verify aging phenotypes. Using multi-omics analyses, we will investigate whether different types of stress regulate a common molecular signature that leads to aging.

Last Application Date: September 19, 2022

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10. PhD Program in Design and production of flexible MEMS based on hetero-structures of materials such as GaN

Summary of Doctoral Project:

The project aims to implement and optimize the growth of GaN and its alloys on structured h-BN in order to manufacture MEMS to be transferred onto flexible substrates. Due to its unique electronic, chemical and mechanical properties, the use of GaN opens the way to a new class of flexible MEMS sensors integrating high-frequency electronics and high-efficiency transduction means for sensor-type applications. implantable or for extreme conditions. The proposed innovative process is based on the selective van der Waals epitaxy method, a concept invented by the Georgia Tech-CNRS international research laboratory and demonstrated for the first time in 2019. Selective growth avoids having to etch the GaN to achieve complex geometries and allows sapphire substrates to be reused after device transfer, leading to a significant reduction in the amount of material used. This technique completely changes the post-processing after growth because the devices can be recovered individually without laser lifting or etching of the substrate. This process has been used to isolate individual chips on a substrate, but not yet for the direct production of mechanical structures with well-defined micrometric geometry.

Last Application Date: 19 September 2022

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11. PhD Program in condensed matter theory

Summary of Doctoral Project:

Graphene launched a revolution in the search for new single-layer materials which today focus on transition metal dichalcogenide (TMD) materials. The latter present signatures of various quantum topological electronic states, insulators or superconductors. A key question is how to exploit the electronic band structure of these states to build useful quantum quasiparticles. For example, we can look for Majorana bound states in superconductors whose braiding would allow quantum computing, or fractional bound states in insulators that can form qubits or can participate in exotic collective states. Recently, it has been shown that electric charge around atomic defects in graphene reveals the semiconductor Dirac band structure of graphene [1]. Unlike graphene, TMD materials have a strong spin-orbit coupling that leads to topological insulator states and exotic superconducting states. We have shown theoretically that atomic defects can produce fractional bound states in topological insulators [2], as well as Majorana bound states in superconductors with spin-orbit coupling [3]. Although various types of defects in TMD materials have been recognized as important for their overall electrical and magnetic behavior, the different bound states associated with the defects are not understood in detail.

Last Application Date: September 19, 2022

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12. PhD Program in Industrial Robotics Thesis – Machine Learning and Automation for Industry

Summary of Doctoral Project:

This thesis project is part of the GANResilRob project, a research action between France and Germany, aimed at developing a more resilient industry. This project involves 2 French SMEs and 1 research institute and 1 SME in Germany, in collaboration with the CNRS from which this position will be recruited. Industrial robots are precise, fast and powerful. While French and German industries are highly automated and equipped with a large number of these robots, the current pandemic crisis has shown very clearly a lack in another key area: flexibility. When global supply chains broke down, France and Germany suffered major disruptions to their industrial production. Both countries were unable to make up for missing parts and materials or quickly transition to new products with available parts and components. Another critical aspect has been the lack of on-site workers, who have had to work in home office environments due to pandemic regulations. Therefore, France and Germany have the potential to overcome this negative impact.

Last Application Date: September 19, 2022

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13. PhD student (M/F), 36 months (with possibility of extension), ERC Synergy Grant NanoBubbles project

Summary of Doctoral Project:

The Interdisciplinary Sciences Innovations Societies Laboratory (UMR LISIS – CNRS, INRAE ​​and Gustave Eiffel University) is recruiting a doctoral student. to join a five-year project funded by the European Research Council entitled “NanoBubbles: how, when and why does science fail to correct itself?”. The aim of the ERC Synergy Grant NanoBubbles project is to understand how, when and why science fails to correct itself. The project combines approaches from the natural sciences, computer science and the social sciences and humanities (in particular Science and Technology Studies, STS) to understand how error correction in science works and what are the obstacles to it. uneven. It focuses on claims in the field of nanobiology, a field for which we seek, through qualitative and quantitative methods, to trace claims and corrections through different scientific communication media (scientific journals, social media, platforms dedicated to error correction, conference programs, etc.). The doctoral student will carry out research on error correction processes, the role of editors/publishers and journals in error correction, but also the role of “epistemic activists” and their platforms in error correction.

Last Application Date: 20 September 2022

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14. CDD PhD student in organic chemistry

Summary of Doctoral Project:

Dynamic Covalent Chemistry (DCC) is fundamental in science. We have demonstrated that the exchanges of sulfur compounds on persulfurized arenas can occur at 20°C and we call it the “sulfur dance”. This process raises questions about the dynamics and reversibility of aromatic substitutions. We found it quite general and important to establish a study in DCC, in addition to reversible functions/reactions with imines, disulphides, thioacyls, dithioacetals, metathesis and the Diels-Alder reaction. Here we take advantage not only of unusual, multi-functional DCC dynamic templates, but especially of persulfided arenas which have additional and unique properties of enhanced luminescence, dyes, REDOX, as detection, monitoring and imaging parameters. The recruited person will carry out work on organic synthesis, purification and characterization of products using various spectroscopic, analytical and separation methods as part of research carried out in an ANR (National Research Agency) project, in particular in dynamic covalent chemistry, chemical organic and materials chemistry. She will be required to write reports, present work and exchange with various high-level partners in an international context.

Last Application Date: 20 September 2022

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15. These: Tri de microcapsules en microfluidique

Summary of Doctoral Project:

The main objective is to develop microfluidic sorting systems for high-throughput selection of capsules filled with cell assemblies (organoids and spheroids). The approach will be validated using two case studies: i) the impact of drugs on the fate (survival and proliferation) of tumor spheroids, and ii) the course of the differentiation of adipose stem cells into adipocytes, which is a crucial cellular event in the control of obesity.

Last Application Date: 12 September 2022

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16. PhD Program in All CELLulose Composites and PHase Change Materials for Insulation

Summary of Doctoral Project:

The CELLPHI project aims to develop and characterize composite materials cellulose – phase change material (PCM) for applications in thermal insulation. The candidate will have a Master’s degree or equivalent equivalent and will have basic knowledge in the physico-chemistry of polymers, and in crystallography or materials engineering. He (or she) will have to prepare materials and carry out measurements by scattering of X-rays at small angles or by diffraction of X-rays at large angles. A preliminary knowledge of cellulosic materials or any other discipline related to the subject is welcome, as well as in Python language.

Last Application Date: 13 September 2022

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17. PhD student in thermomechanical simulation

Summary of Doctoral Project:

To develop numerical tools based on the discrete element method (DEM) to study the relationships between the microstructure and the thermomechanical properties of model materials. These developments include stripping, thermomechanical coupling, crack closure and anisotropic behaviors. These developments will lead to a “virtual digital laboratory” capable of providing virtual tensile, dilatometry, fracture mechanics or thermal shock tests for virtual characterizations. The related developments will be integrated into the free software of DEM GranOO.

Last Application Date: September 13, 2022

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18. SAT doctoral contract for formal verification in method B

Summary of Doctoral Project:

The ANR BLaSST project aims to establish a bridge between combinatorial and symbolic techniques in the automatic proof of theorems, in particular for proof obligations generated from B models. Work will be carried out on techniques based on SAT as well as on more expressive SMT formalisms. In both cases, encoding techniques, optimized resolution techniques, model generation and lemma suggestion will be considered. By combining the two lines of work, the expected scientific impact is a substantially higher degree of automation of solvers for expressive input languages ​​by exploiting higher-order reasoning and enumerative instantiations over finite domains. L’ effectiveness of the techniques developed in the project will be quantified by applying them to reference sets provided by the industrial partner. The industrial impact of BLaSST will be greater productivity of proof engineers.

Last Application Date: 13 September 2022

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19. PhD in macrophage mechanobiology

Summary of Doctoral Project:

Macrophages are professional phagocytes of the immune system. One of their key roles is to ingest and digest large particles, a process called phagocytosis, which involves dynamic actin reorganization and the generation of mechanical forces. The molecular mechanisms at play during the formation and closing of the phagocytic cup, as well as the forces involved in actomyosin contractility, are still poorly documented and understood. We recently reported the involvement of podosome-like structures in phagocytosis, which we have previously described as producing protrusive forces on the extracellular environment. In order to study the mechanics of phagocytosis, we have just developed a new model of frustrated 2.5D phagocytosis consisting of networks of flexible micropillars of controlled stiffness. Using fluorescence microscopy, we are studying the dynamics of the phagocytic cup forming along the surface of osponized pillars and have begun to quantify subcellular forces, and this approach will allow us to better decipher the molecular mechanisms involved in the mechanobiology of phagocytosis.

Last Application Date: 13 September 2022

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20. Call for applications Doctoral contract

Summary of Doctoral Project:

The thesis falls within the field of historical political economy. She will contribute to the objective of the project, which is to assess the political and economic effects of the Second World War in France. More precisely, the interdisciplinary project seeks to know how the Second World War, in its different historical aspects (war and destruction, national division, liberation, etc.) and its consequences, had both political repercussions (functioning of democracy French, electoral behavior, selection of political personnel, …) and socio-economic (economic development, population health, …).

Last Application Date: September 14, 2022

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21. PhD student (M/F): ultrafast electron microscopy of nanomaterials

Summary of Doctoral Project:

The candidate will work for a period of three years as a doctoral student in the Department of Structures and Interfaces at the Institute of Physics and Chemistry of Materials in Strasbourg (IPCMS, UMR 7504). Under the responsibility of Prof. Florian BANHART, He/she will contribute to the scientific tasks of the NANOHEATERS project (selected by the ANR in 2022). This is fundamental research aimed at studying the thermal behavior of nanoparticles under light pulses. These studies will be carried out by time-resolved electron microscopy. This pioneering technique has been developed at the IPCMS since 2014. It consists of operating a transmission electron microscope in “pump-probe” mode: a first laser pulse excites the sample, i.e. induces a transformation.

Last Application Date: September 14, 2022

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22. PhD Program in Dynamic Study of the 3D Morphological Evolution of All-Solid Li-ion Batteries during their Manufacture and Cycling

Summary of Doctoral Project:

The objective of my thesis is the analysis and quantification of the evolution of the 3D morphology of all-solid Li-ion batteries. The dynamic study in morphology will be based on the use of X-ray tomography imaging techniques at different scales (μ and nano) and the analysis of time series by “Deep Learning” algorithms.

Last Application Date: September 14, 2022

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23. PhD Program in Dynamics of the autoimmune response in extramembranous glomerulonephritis

Summary of Doctoral Project:

This project proposes to analyze the dynamics of the autoimmune response in the GEMs associated with PLA2R1 and THSD7A “in reverse”, from the declared disease (diagnosis) to the early events associated with the rupture of tolerance, and to try to reproduce the different phases of the autoimmune response in animals.

Last Application Date: 14 September 2022

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24. PhD Program in Numerical modeling of the mesoscopic plasticity of crystals by the invariant nonlinear elasticity GL(3, Z)

Summary of Doctoral Project:

This thesis project is not only theoretical in nature but also large-scale computational in nature. The objective of the thesis is to study the 3D model of the Landau type in large deformation, already developed in 2D. The numerical framework is nonlinear elasticity with invariance GL(3,Z). The main challenge is to develop robust algorithms for our specific nonconvex minimization problems with a very large number of degrees of freedom. The parallelization techniques will be implemented in an in-house C++ code. The numerical results will be compared with classical calculations of crystalline plasticity or with analytical predictions. Finally, the 3D code will be used for the study of different problems of mesoscopic crystalline plasticity.

Last Application Date: September 14, 2022

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25. PhD in artificial intelligence applied to cosmology

Summary of Doctoral Project:

Your thesis project aims to advance the state of the art of cosmological data analysis based on these innovative methods. This includes integrating them into pipelines, validating them in simulations, and collaborating with simulators and deep learning specialists. You will quantify for the first time the cosmological information inherent in astronomical datasets and discover the challenges of analyzing datasets where the information is encoded in a non-linear way. You will explore a high-dimensional parameter space guided only by a limited number of expensive simulations. You will develop and use fast deep emulators to accelerate sophisticated physical models of cosmic structure formation and galaxy formation. You will work with many existing computer codes as well as you will develop your own methods and publish not only articles but also your code.

Last Application Date: 15 September 2022

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26. Doctoral thesis (M/F) on the thermo-tomography of interfaces buried in micro-supercapacitors

Summary of Doctoral Project:

This thesis has two main objectives. The first will be to develop an experimental system capable of reconstructing the 3D temperature field as a function of time in a heterogeneous microstructure using non-contact optical techniques. In practice, the candidate will start from a thermo-transmittance device under development and improve it to obtain time-resolved information in three dimensions. The second objective will be to apply this new technique to the complete thermal characterization of MSCs in operation. From the measurements, we will find the temporal thermal behavior of the different materials, including T(x,y,z,t) and the thermal properties.

Last Application Date: September 15, 2022

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27. PhD Program in Experimental Nuclear Physics

Summary of Doctoral Project:

Cross sections of neutron-induced reactions on short-lived radioactive nuclei are essential for understanding the stellar synthesis of chemical elements and for industrial applications. However, their measurement is very complicated, if not impossible, due to the high radioactivity of the targets required. The most promising alternative to determine these cross sections is the use of substitution reactions in inverse kinematics. These reactions cause a beam of heavy ions to interact with light targets and make it possible to form the same nuclei as those formed after the capture of a neutron. NECTAR (Nuclear rEaCTions At storage Rings), in which the proposed thesis work falls, is a project funded by a prestigious grant from the The objective of the proposed thesis is to participate in the preparation and the realization of the next NECTAR experiment which will take place at GSI/FAIR. The candidate will be responsible for carrying out simulations to optimize the experimental device.

Last Application Date: 09 September 2022

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28. PhD Program in theoretical and experimental study of pollinator movements across the landscape

Summary of Doctoral Project:

The work is part of the European ERC Cog BEE-MOVE project which aims to study the movement of pollinators and their interactions across the landscape to better understand pollination processes. The objective will be to develop a numerical model capable of predicting the movements of pollinators and the consequences on the pollination of plants. This model will generate hypotheses that will be tested experimentally in the field with real pollinators and real plants.

Last Application Date: September 15, 2022

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29. PhD student in organic synthesis

Summary of Doctoral Project:

Three- and four-membered carbocycles and heterocycles are attracting growing interest in medicinal chemistry. Their constrained conformation allows a well-defined spatial arrangement of substituents, which leads to very good affinities and selectivities for biological targets. In addition, the incorporation of these motifs makes it possible to modulate the pharmacokinetic properties. In this context, the objective of the thesis work is to develop reduction reactions by asymmetric hydrogen transfer, catalyzed by transition metal complexes, new classes of substrates to efficiently access cyclopropanes, cyclobutanes, oxetanes and variously substituted azetidines, incorporating several stereogenic centers, which constitute molecular building blocks of interest in organic synthesis. Experimental conditions for asymmetric hydrogen transfer will have to be developed for each class of unsaturated substrates in order to access constrained carbocycles and heterocycles with excellent control of enantioselectivity and diastereoselectivity. The field of application, in terms of substrates, and subsequent functionalizations of the products will be studied in order to demonstrate the interest of the methods developed.

Last Application Date: 16 September 2022

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30. PhD position: Amorphous nanomaterials in qubits and PCMems: thermal transport and quantum tunneling by atomistic modeling

Summary of Doctoral Project:

This PhD project in modeling aims to study the thermal properties of amorphous nanomaterials and the quantum tunneling effect of defects in these amorphous materials by applying advanced computational methods and at the atomic scale. This double challenge is of fundamental importance for applications in quantum computing (coherence of qubits) and for phase change memories (thermal management of phase change memories or PCMems). With regard to defects, the main objective will be to determine at the microscopic level the nature of the two-level systems (ie two-level systems or TLS) which are suspected of causing the loss of coherence of the qubits. The detailed microscopic vision obtained by this work will make it possible to access fundamental information on the energy landscapes and the tunneling effect of low-temperature TLS. Additionally, these studies will stimulate computational design experiments in which a superconducting quantum material can be employed to study one or more TLSs. At higher temperatures, the result will be an understanding of the nature of vibrational modes in amorphous materials and the range of associated mean free paths that determine the sensitivity of thermal properties to downscaling.

Last Application Date: September 12, 2022

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