Pasteur Institute has huge a campus in Paris, France and widely known as for its contribution in top notch education and research. The contribution of Pasteur Institute is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Post-doctoral positions: Population imaging and holographic stimulation during perceptual decision making

Summary of Postdoctoral Fellowship:

Perceptual discriminations are among the most important decision making processes. One of the most prominent questions in systems neuroscience is how the perception of a given stimulus is encoded in the brain and how this translates to a learned decision that is followed by a motor response. Using the repertoire of experimental techniques available in our lab, such as two-photon and three-photon imaging, multi-electrode extracellular recordings, patch-clamp recordings, holography based optogenetics and psychophysics in awake behaving animals, our goal is to characterize in detail single-cell and neural network activity in the rodent cortex during the learning process of a decision making task. The postdoc will be able to choose among several projects that will use the cutting-edge infrastructure of the lab: Imaging bi-hemispheric interactions during decision making using a novel dual-head two-photon microscope. Deep imaging of prefrontal cortex activity during decision making using three-photon excitation. Holographic stimulation of neurons to probe cortical coding schemes relevant for perception (see e.g. Musall et al. 2014, Nature Neuroscience).

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2. Biophysics postdoc position – Dynamics of developmental processes

Summary of Postdoctoral Fellowship:

A postdoctoral position is available to study dynamic processes in early development of insects and mammals. Successful candidates will join a collaborative and interdisciplinary venture in the newly formed unit Physics of Biological Function of biophysicist Thomas Gregor.

Last Application Date: Open Until Filled

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3. Medical microbiologist, French National Reference Center for diphtheria

Summary of Postdoctoral Fellowship:

The Biodiversity and Epidemiology of Bacterial Pathogens research unit hosts the National Reference Center for diphtheria. In order to develop our research projects on Corynebacterium diphtheriae and to strengthen our surveillance activities on diphtheria at the national level, we are looking for a medical microbiologist. Hosting in the lab could be realized under different modalities including a ‘poste d’accueil’, an ‘interface contract’, a post-doctoral fellowship or a PhD. A perspective for a fixed-term position is an important characteristic of this offer.

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4. Post-doc in Di Nunzio’s laboratory: Deciphering HIV-induced membraneless organelles (HIV-MLOs) in the nuclear space.

Summary of Postdoctoral Fellowship:

Please see below for more details.

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5. Post-doctoral position: Immune- brain communication mechanisms

Summary of Postdoctoral Fellowship:

The brain is very hard to cure. Drugs have a hard time crossing the blood-brain barrier and if they do – the side effects of their activity in such a fragile environment may be disastrous. Our lab strives to describe and uncover an alternative approach to brain treatment. We study how peripheral signals, such as immune cells present at the brain borders, shape brain physiology, how the dysfunction of such communication pathways can contribute to brain aging or disease, and how we can exploit such pathways to cure the brain. We especially explore the immune niche of the choroid plexus (one of the brain borders), and the roles and signatures of microglia and border associated macrophages (Baruch, Deczkowska et al., Science, 2014; Schwartz & Deczkowska, TrendsImmune, 2016; A Deczkowska, O Matcovitch-Natan et al, Nat.Comms. 2017; Deczkowska et al., Nat.Neurosci. 2018; Deczkowska et al., Cell. 2018, 2020). The work includes single cell RNA-seq approaches, spatial transcriptomics, state of the art tools of immunology and neuroscience (incl. behavioral tests), mouse models, lots of genomic data and more!

Last Application Date: Open Until Filled

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6. Research Engineer tenure position in Hydrogen/Deuterium Exchange Mass Spectrometry

Summary of Postdoctoral Fellowship:

The Biological NMR and HDX-MS platform at the Institut Pasteur in Paris is looking for an experienced research scientist specialized in Hydrogen/Deuterium eXchange Mass Spectrometry to reinforce its activity. Bio-NMR-HDX is part of the Center for Technological Resources and Research (C2RT) and is affiliated to the Department of Structural Biology and Chemistry. Our mission in HDX-MS is to provide full support to Institut Pasteur research teams mainly through collaborative projects and to develop the HDX-MS technology in order to address present and future technological needs and challenges. Most of our HDX-MS projects focus on soluble, membrane-associated or integral membrane proteins that are either involved in infectious diseases (such as bacterial toxins), antibiotic resistance or considered as potential drug targets.

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7. Post-Doc Offer : Neutrophils in the onset and propagation of antibody-driven autoimmunity

Summary of Postdoctoral Fellowship:

We are looking for an enthusiastic, independent, and innovative candidate who works well in a team and is eager to drive this translational project forward. Candidates must hold a doctoral degree (Ph.D. or MD) in immunology or related fields. Highly motivated candidates with a strong background in immunology, molecular biology, and/or genetics and substantial experience with flow cytometry and in vivo mouse models are encouraged to apply. Previous experience in conducting and analyzing neutrophil or platelet functions or scRNA-seq experiments is an asset. Good communication skills and fluency in English are essential.t

Last Application Date: Open Until Filled

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8. RESEARCH ENGINEER in ELECTRON MICROSCOPY – permanent position

Summary of Postdoctoral Fellowship:

The Ultrastructural BioImaging platform is in Paris. The platform is equipped with 5 electron microscopes and 20 sample preparation systems. The recruited engineer will work on biological samples and will be in charge of implementation and development of transmission and scanning electron microscopy methods. Under the responsibility of the Platform Director, the engineer will have the opportunity to interact with other imaging platforms, to apply for Grants and will be in charge of equipment (microscopes, preparation systems).

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9. Postdoctoral position in Auditory Neuropathy Spectrum Disorders

Summary of Postdoctoral Fellowship:

A postdoctoral position with 24 months of funding is available immediately for an advanced scientist in audiology, biophysics or neurosciences at the Centre for Research and Innovation in Humans (CERIAH) codirected by Professor Paul Avan and Professor Hung Thai-Van at the Institut de l’Audition, Institut Pasteur, in Paris, France. We are seeking an outstanding, highly motivated postdoctoral fellow for a project on fine characterization of auditory impairments by developing an innovative set of objective audiological measurements and psychoacoustics in humans. The goal of this large-scale project is to improve hearing aids for patients suffering from Auditory Neuropathy Spectrum Disorders (ANSD).

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10. Postdoctoral position in mosquito population genomics at Institut Pasteur in Paris

Summary of Postdoctoral Fellowship:

The Insect-Virus Interactions Unit at Institut Pasteur in Paris is looking for a postdoctoral researcher to investigate the genomic variation underlying a mosquito’s ability to transmit human pathogens. Our research group applies genomic technologies to study populations of Aedes mosquitoes and their role in the transmission of arboviruses such as dengue and Zika viruses. Specific interests of our group include the genetic architecture of arbovirus susceptibility, the contribution of transposable elements to antiviral defense, and the effect of mosquito ecology on genomic evolution. We are looking for an enthusiastic and versatile postdoc to apply existing bioinformatic methods and develop new pipelines to analyze and interpret high-throughput sequencing data. In addition to performing bioinformatic analyses of ongoing projects, the successful candidate will have considerable freedom to develop related research projects according to their interests.

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11. Three-year Postdoctoral Position at Institut Pasteur, Paris, France (Prokaryotic Cell Biology, Evolution)

Summary of Postdoctoral Fellowship:

The Archaea have recently come to center stage, not only because of their key role in the origin of eukaryotes (1), but also as important yet neglected residents of the human microbiome (2). We have recently developed the first experimental model of a host-associated archaeon, Methanobrevibacter smithii, the main species of methanogens from the human gut. We have demonstrated that M. smithii is an ovococcoid that divides binarily using a homologue of FtsZ and its anchor SepF (3). Interestingly, while most archaea contain a proteinaceous S-layer as major component of the cell envelope, M. smithii and its close relatives possess a cell wall made of pseudopeptidoglycan (pPG). It structurally resembles its bacterial counterpart, but is chemically distinct, indicating an independent evolutionary origin. How these archaea “reinvented” a pPG cell wall, and what were the consequences at the cellular level are fascinating open questions. In fact, the archaeal machineries involved in cell growth and division in the presence of a pPG cell wall remain largely unknown (4).

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12. Manager of the Organ-on-Chip Center

Summary of Postdoctoral Fellowship:

The position is open for a research engineer specialized in the development and use of MicroPhysiological systems. The selected candidate will oversee the Organ-on-Chip Center that provides Emulate technology to the campus. She / He will devise, adapt, and implement different Organ-on-Chip protocols. She / He will liaise with users and propose relevant strategies for advancing host-pathogen interactions projects on-chip. In parallel, the selected candidate will also support and interface with the other activities of the Biomaterials and Microfluidics core facility including 3D cell culture, organoid services, custom microfluidic devices.

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13. Post-doctoral position in bacterial metabolomics

Summary of Postdoctoral Fellowship:

We have a two years fellowship funded by the Labex IBEID for a post-doctoral fellow specialized in metabolomics and microbiology to work in the frame of a consortium of teams at the Institut Pasteur. The selected candidate will be working at the Metabolomics Core Facility headed by Sandrine Aros and in the Biology and Genetics of the Bacterial Cell Wall Unit headed by Ivo G. Boneca. The other teams of the consortium are the Imaging and Modeling Unit (Christophe Zimmer) and UTechS Photonic BioImaging (Spencer Shorte).

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14. Postdoctoral position in Chromatin and Infection

Summary of Postdoctoral Fellowship:

In the laboratory we study how epigenetics contribute to establishing the delicate balance that exists between homeostatic responses to commensal bacteria and virulence processes to pathogenic bacteria. Uncovering the mechanisms at the root of this balance is crucial for understanding how invasive infections begin, how asymptomatic colonizations are maintained, and for potential designing of treatment. We have integrated histone modifications in phenotypic responses to bacteria to show important mechanisms exploited by bacteria to subvert the host and impose an efficient infection 1–4, but have also demonstrated that chromatin modifiers can be critical regulators of homeostasis and bacterial containment 5. To all of our projects we bring our multidisciplinary expertise, mixing molecular genetics to microbiology, ensuring a balance between mechanistic studies and physiology.

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15. Research Engineer in Biological NMR – tenure position

Summary of Postdoctoral Fellowship:

The team provides state of the art solution NMR and HDX-MS techniques to study at an atomic or molecular level protein interactions, dynamics, structure, fragment and ligand screening, post-translational modifications, real-time kinetics, chemical structure of carbohydrates and small compounds. In addition, we provide machine time and expertise to on campus biological NMR experts as well as for chemists for routine analysis. In NMR, the facilities host cutting-edge 800 and 600 MHz spectrometers equipped with cryogenic probes and sample changers dedicated to biological NMR, and a 500 MHz mainly used for routine chemistry. We are at the heart of the Institute core facilities dedicated to structural biology (cryo EM, XR crystallography, biophysics and protein production) and collaborate with many microbiology, virology and structural biology groups in a very stimulating scientific environment.

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16. Postdoc position: Evolutionary and epidemiological dynamics of a generalist Klebsiella pneumoniae sublineage

Summary of Postdoctoral Fellowship:

To better understand Kp transmission across niches, a new ‘One Health’ approach to Kp research is needed. This will be achieved either by: i) sampling Kp at niche interfaces (e.g., food versus human carriage in controlled settings); or ii) by focusing on known host-generalist clones (sublineages) with sufficient sampling in several niches to attain statistical significance in GWAS studies and to observe niche jumps through phylogenetic approaches. Recent One Health studies have revealed a huge diversity of Kp sublineages in several sources, including nosocomial infections, human carriage, food, soil and animal carriage or clinical infections. Notable exceptions are peculiar types of infection such as liver abscess or rhinoscleroma. However, a few sublineages stand out for having a higher prevalence in multiple niches compared to most sublineages.

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17. Post-doc position: Contribution of variable microbial factors and host immunity to the development of severe pertussis (whooping cough) in infants

Summary of Postdoctoral Fellowship:

We are looking for a young talented researcher for “omics” analyses of both B. pertussis isolates and immune responses during severe pertussis in infants, and their role on the occurrence of the fulminant form of pertussis, through the investigations of the following aspects: Bacterial transcriptomics profiling, Functional studies of virulence genes on cellular infection models, Microbial isogenic mutants and in vitro functional analyses, Immune cell phenotyping, Cytokines and chemokine secretion measurement, Transcriptomics profiling of immune cells.

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Pasteur Institute has huge a campus in Paris, France and widely known as for its contribution in top notch education and research. The contribution of Pasteur Institute is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..

1. Biophysics postdoc position – Dynamics of developmental processes

Summary of Postdoctoral Fellowship:

A postdoctoral position is available to study dynamic processes in early development of insects and mammals. Successful candidates will join a collaborative and interdisciplinary venture in the newly formed unit Physics of Biological Function of biophysicist Thomas Gregor.

Last Application Date: Open Until Filled

View Details & Apply

2. Postdoc position in Human Genetics to study genetics of brain diversity in autism

Summary of Postdoctoral Fellowship:

Our laboratory is part of the Neuroscience Department of the Institut Pasteur and gathers psychiatrists, neuroscientists and geneticists to understand the causes of autism. We previously identified the first mutations in the NLGN-NRXN-SHANK pathway, which has a key role in synapse formation within the brain. Our results highlight the genetic heterogeneity of autism, but also point at common biological mechanisms that could constitute relevant targets for new treatments. We are leading the genetic work package of AIMS-2-TRIALS, the largest European project on autism research. The project is focused on deep-phenotyping of individuals with autism and controls including brain imaging (EEG and MRI) and a battery of cognitive tests. Our group is currently developing new methods for analyzing whole genome and brain imaging data as well as new paradigms for characterizing mouse social and vocal behaviors.

Last Application Date: Open Until Filled

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3. Postdoc position in Neuroimaging of autism

Summary of Postdoctoral Fellowship:

Our laboratory is part of the Neuroscience Department of the Institut Pasteur and gathers psychiatrists, neuroscientists and geneticists to understand the causes of autism. We previously identified the first mutations in the NLGN-NRXN-SHANK pathway, which has a key role in synapse formation within the brain. Our results highlight the genetic heterogeneity of autism, but also point at common biological mechanisms that could constitute relevant targets for new treatments. We are leading the genetic work package of AIMS-2-TRIALS, the largest European project on autism research. The project is focused on deep-phenotyping of individuals with autism and controls including brain imaging (MRI, fMRI, DTI and EEG) and a battery of cognitive tests. Our group is currently developing new methods for analyzing whole genome and brain imaging data as well as new paradigms for characterizing mouse social and vocal behaviors.

Last Application Date: Open Until Filled

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4. Five Postdoctoral and Engineer positions – Epigenetic-based therapies to fight infectious diseases

Summary of Postdoctoral Fellowship:

Five positions (four postdoctoral and one engineer) are available to join an interdisciplinarity consortium, located in the Paris area, to study the interplay between epigenetic regulation and infectious diseases. Our objective is to find new therapeutic approaches to fight infection using epigenetic drugs. Our consortium combines expertise in the biology and epigenetics of infection (5 teams), in proteomics (1 team) and in drug-design and medicinal chemistry of epigenetics (2 teams). The partners are internationally-oriented research structures, located at the Pasteur Institute (6 laboratories), University of Paris (1 laboratory) and University Paris Saclay (1 laboratory). The strengths of the consortium are: (1) a strong track-record showing that pathogens modulate host epigenetic mechanisms; (2) considerable resources generated by medicinal chemists; (3) in-depth expertise on seven biological models, from in vitro and in cellulo to in vivo models. The research environment includes state-of-the-art equipment and facilities for the project. Salaries are funded for at least two years and will be adjusted according to the experience of the candidate.

Last Application Date: Open Until Filled

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5. Post-doc in Di Nunzio’s laboratory: Deciphering HIV-induced membraneless organelles (HIV-MLOs) in the nuclear space

Summary of Postdoctoral Fellowship:

Please click on view details for full details.

Last Application Date: Open Until Filled

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6. 1 year (extension possible) Post doc position opened in the Molecular Mycology Unit (Mycology department)

Summary of Postdoctoral Fellowship:

In brief, invasive fungal infections (IFIs) are associated with high mortality rate. Despite antifungal drug treatment, the prognosis of IFIs is poor due to inadequate efficacy of the drugs, variable drug- susceptibility across fungal species due to their complex biological cycle and the emergence of drug-resistant strains. This demands new/alternative therapeutic strategies. On the other hand, cell wall is the fungal first component to interact with the host immune system. However, polysaccharides, the main constituents of the fungal cell wall are under-explored in the context of immunotherapy. This is due to several drawbacks associated with the fungal cell wall polysaccharides. Our project aims at overcoming those drawbacks of cell wall polysaccharides and making them useful in immunotherapies against fungal pathogens.

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7. Postdoctoral position – Mechanisms of HIV control in the absence of antiretroviral treatment

Summary of Postdoctoral Fellowship:

A funded post-doctoral position is available to develop a research program in the context of the ERASE HIV collaboratory studying the immune mechanisms contributing to HIV remission. The successful applicants will develop their research in the “HIV Inflammation and Persistence Lab” at Institut Pasteur in Paris, under the supervision of Dr Asier Sáez-Cirión. Dr Sáez-Cirión’s group is interested in understanding the mechanisms underlying control of HIV infection in rare individuals who are able to maintain undetectable viral loads for very long periods of time in the absence of antiretroviral treatment. The research program will be focused on the processes that lead to the development of optimal immune responses to counteract infection naturally or after early treatment initiation. Experimental approaches will cover cellular biology, immunology and virology.

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8. Post-Doctoral research fellow: Characterizing immune responses following combination therapies in HBV infections

Summary of Postdoctoral Fellowship:

Current treatment strategies for HBV are life-long and rarely curative. Although HBV infects hepatocytes, its evasion and modulation of the immune response is key to the pathophysiology. The goal is to analyze the response to HBV during and after treatment with a combination of antiviral and immune modulating therapies using an immune competent humanized mouse model. Innate and adaptive immunity will be probed to determine whether efficient immune responses may be restored, leading to seroconversion and a functional cure off treatment. We aim to decipher the immune response leading to viral persistence versus viral control and uncover predictive biomarkers of each state.

Last Application Date: Open Until Filled

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9. Post-doctoral position: Immune- brain communication mechanisms

Summary of Postdoctoral Fellowship:

The brain is very hard to cure. Drugs have a hard time crossing the blood-brain barrier and if they do – the side effects of their activity in such a fragile environment may be disastrous. Our lab strives to describe and uncover an alternative approach to brain treatment. We study how peripheral signals, such as immune cells present at the brain borders, shape brain physiology, how the dysfunction of such communication pathways can contribute to brain aging or disease, and how we can exploit such pathways to cure the brain. We especially explore the immune niche of the choroid plexus (one of the brain borders), and the roles and signatures of microglia and border associated macrophages (Baruch, Deczkowska et al., Science, 2014; Schwartz & Deczkowska, TrendsImmune, 2016; A Deczkowska, O Matcovitch-Natan et al, Nat.Comms. 2017; Deczkowska et al., Nat.Neurosci. 2018; Deczkowska et al., Cell. 2018, 2020). The work includes single cell RNA-seq approaches, state of the art tools of immunology and neuroscience (incl. behavioral tests), mouse models, lots of genomic data and more!

Last Application Date: Open Until Filled

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10. Postdoctoral position in Stromal Immunoregulation

Summary of Postdoctoral Fellowship:

One funded postdoctoral position is available in the lab “Stroma, Inflammation and Tissue Repair” (Institut Pasteur, Department of Immunology, co-affiliated with Developmental and Stem Cell Biology) to explore the crosstalk between stromal cells and immune system in the context of chronic inflammation, diet-microbiome-adipose tissue axis and the metabolic syndrome. The stromal microenvironment is increasingly recognized as an upstream organizer of tissue homeostasis and immune responses. Our lab has performed pioneering work on the role of stromal cells in tissue homeostasis and how perturbation of stromal pathways impacts on repair responses and inflammatory diseases (Dulauroy, Nature Medicine 2012; Stzepourginski, PNAS 2017; Di Carlo, JCI 2018; Benabid, Current opinion Immunol 2020; Jacob, Cell Stem Cell 2022). In this project, we want to understand how stromal cells sense their environment to maintain tissue homeostasis while ensuring efficient responses to external challenges, with a focus on the adipose tissue and mucosal tissues. To go beyond the state-of-the-art, we will perform phenotypic, functional and transcriptomic based screens (bulk/ single cells RNAseq) to identify stromal subsets and genes that regulate tissue homeostasis and remodeling, building on preliminary data obtained in the lab.

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11. Post-Doc Offer : Neutrophils in the onset and propagation of antibody-driven autoimmunity

Summary of Postdoctoral Fellowship:

We are looking for an enthusiastic, independent, and innovative candidate who works well in a team and is eager to drive this translational project forward. Candidates must hold a doctoral degree (Ph.D. or MD) in immunology or related fields. Highly motivated candidates with a strong background in immunology, molecular biology, and/or genetics and substantial experience with flow cytometry and in vivo mouse models are encouraged to apply. Previous experience in conducting and analyzing neutrophil or platelet functions or scRNA-seq experiments is an asset. Good communication skills and fluency in English are essential.

Last Application Date: Open Until Filled

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