Are you holding Master’s degree and looking for PhD positions – Fully Funded PhD Programs in Europe? Karolinska Institute, Sweden inviting application for funded PhD Programs or fully funded PhD Scholarship. Karolinska Institute is one of the largest university in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.
Karolinska Institute has huge a campus in Sweden and widely known as for its contribution in top notch education and research. The contribution of Karolinska Institute is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc.
1. Doctoral (PhD) student position in molecular studies on human vaginal wound healing
Summary of Doctoral Project:
There are several congenital conditions affecting the formation of vaginal canal. Tissue engineering may provide a way to improve surgical corrections and improve the wellbeing and reproductive capabilities of the affect population. We have identified a knowledge gap on the biological mechanisms that determine a normal healing of the human vagina. In general, wound healing could be defined as the tissues natural capacity to replace injured cells and to heal wounds. This PhD project aims at giving a deep education in basic science and tissue healing biology. The project involves the exploration of transcriptomics during normal vaginal tissue healing. The doctoral student will work on clinical samples for studies in human primary cell cultures and will learn and practice several molecular cell biology methods including isolation, expansion and creation of vaginal 3D models, immunofluorescence, western blot, gene editing, cell transfection, digital PCR, microscopy, histological preparations, and studies in small animal models. A part of the study will involve bioinformatic analysis of gene expression profiles.
Last Application Date: 04.Sep.2022
2. Doctoral (PhD) student position in the project “Mechanisms of Amyloid Formation and Inhibition in Parkinson’s disease”
Summary of Doctoral Project:
We are looking for a doctoral student in the research group of Assistant Prof. Axel Abelein and Prof. Jan Johansson. The research group studies protein misfolding and amyloid structures related to neurodegenerative diseases, in particular Alzheimer’s and Parkinson’s disease, as well as biomaterials. The working space is located in Neo, KI Campus South in Flemingsberg, at the Department of Biosciences and Nutrition. The group consists of one professor, two assistant professors, two senior scientists and six post-docs and PhD students, providing a stimulating and supportive environment for a new PhD student.
Last Application Date: 19.Aug.2022
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3. Doctoral position in identification of novel atheroprotective pathways mediated by HDL
Summary of Doctoral Project:
High density lipoproteins (HDL) protect against atherosclerotic cardiovascular disease additive to and beyond their commonly clinically measured cholesterol component. HDL can e.g. elicit cholesterol efflux from macrophage foam cells, decrease endothelial inflammation and inhibit oxidative modification of LDL particles. However, the clinical utility of HDL function assays is still only beginning to be explored and insufficient knowledge exists with respect to molecular pathways corresponding to HDL-related signal transduction. The current PhD project represents a continuation of our previous seminal contributions to advance the concept of HDL function (e.g. Circulation 2021, 143, 1935; Diabetes 2019, 68:1915; JASN 2017, 28: 769) The aims of the project are (i) to provide novel insights into molecular signalling pathways triggered by HDL and (ii) to delineate the clinical value of these using material from prospective cohort studies. Within this framework, the PhD student will work with techniques such as cell culture, real-time PCR, cloning, Western blot, CRISPR-Cas9 technology, RNA sequencing, mass spectrometry, bioinformatics, and biostatistics. Using established protocols together with a variety of educational activities by Karolinska Institutet the PhD student will be offered unique learning opportunities for a career in cardiometabolic research.
Last Application Date: 12.Aug.2022
4. Doctoral (PhD) student position in computational and structural biology of cancer mutations in novel targets
Summary of Doctoral Project:
Our lab on “Protein Dynamics and Mutation” strives to push biomedical research beyond its current boundaries integrating simulations and experiments at different scales. Our goal is to understand the structural and conformational mechanisms of proteins and how are they affected by cancer and mendelian disorders. We aim to recruit a team of passionate scientists at the cross-roads of structural and computational biology, with a genuine interest in human diseases and life mechanisms from a biophysical perspective. The group expertise encompasses from the development of coarse-grained and atomistic simulation methods to cryo-electron microscopy. Our research is performed in an interdisciplinary setting with strong collaboration with experimentalists and clinicians at KI, as well as national and international groups. Approximately 300 people from over 40 nations are currently working at the Department of Oncology-Pathology in about 30 research groups with cancer research profiles spanning from basic to translational and clinical research.
Last Application Date: 15.Jul.2022
5. Doctoral studies in Central Nervous System Regeneration
Summary of Doctoral Project:
Our lab investigates fibrotic scar formation and its impact on axonal regeneration and functional recovery following lesions to the central nervous system (CNS). We discovered a new population of perivascular cells, called type A pericytes, as the source of fibrotic scar tissue (Göritz et al., Science, 2011) and identified pericyte-derived scar formation as a therapeutic target to achieve axonal regeneration and functional recovery following spinal cord injury (Dias et al., Cell, 2018). Recently, we showed that fibrotic scarring by perivascular cells is a conserved mechanism in the adult mammalian CNS (Dias et al., Nature Com., 2021). The intended project builds on these findings and aims at further elucidating the mechanism of fibrotic scar formation in models of multiples sclerosis and its role for remyelination. You will use a number of innovative technologies in combination with genetic mouse models to identify cellular interaction partners and molecular pathways for in vivo target identification. Through combining in vivo lineage tracing with molecular expression profiling and in vivo pathway manipulation, the project will chart therapeutic opportunities for treating nerve/spinal cord damage in humans.
Last Application Date: 26.Jul.2022
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6. Doctoral studies in regeneration of insulin-producing beta-cells
Summary of Doctoral Project:
We are seeking a highly creative, motivated and enthusiastic doctoral student to study regeneration of pancreatic beta-cells as an approach to curing diabetes. The lab uses chemical screening techniques in zebrafish larvae to identify and characterize compounds, signaling pathways and cellular mechanisms that can promote β-cell regeneration. We then validate our initial findings by changing the stage (larvae vs adult), approach (chemical vs genetic), and model organism (zebrafish vs mouse). Additionally, the prospective student will study how reinforcing gut-pancreas signalling can expand the β-cell mass and improve glucose control in diabetes. The molecular mechanisms of the identified drug candidates will be elucidated using single-cell RNA-seq of control and treated zebrafish.
Last Application Date: 10.Aug.2022
7. Doctoral student – Mechanisms of intercellular mitochondrial transfer in alzheimer’s disease
Summary of Doctoral Project:
The Ankarcrona Lab currently consists of five people with different academic levels and backgrounds, educationally as well as culturally. The focus of the research group is the understanding of mitochondrial dysfunction mechanisms leading to synaptic alterations and neurodegeneration, and the search for mitotherapeutics with potential to reach clinical studies. The current projects on the lab are focus on i) the study of mitochondria-endoplasmic reticulum (ER) contact sites and how these structures affect synaptic function and inflammasome activation; and ii) the transfer of mitochondria between neuronal cells. Along the past years Ankarcrona group has done important discoveries in the field of mitochondria and Alzheimer´s disease such as the identification of the pathways by which amyloid-β internalize in mitochondria and the discovery of new modulators of mitochondria-ER contact sites (Hansson Petersen et al. 2008 PNAS, Hedskog et al. 2013 PNAS, Filadi et al. 2018 Current Biol.; Naia et al. 2021 BMC Biol.)
Last Application Date: 01.Aug.2022
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