Scripps Research has huge a campus in California, USA and widely known as for its contribution in top notch education and research. The contribution of Scripps Research is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, etc..

1. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Scripps Research is seeking a Postdoctoral Associate in the Scott Henderson Lab to support in the following areas: Undertake collaborative projects related to super-resolution microscopy. Assist with operations of super-resolution microscopy systems, including a newly installed MINFLUX system. Provide training on the operation of the super-resolution microscopes to Scripps Research scientists, faculty and staff. Oversee operation of super-resolution microscopes and maintenance of ancillary equipment, including QC, validation, and day-to-day operation. Undertake sample preparation for super-resolution microscopy.

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A funded postdoctoral position is available in the Laboratories of Jeffery Kelly and Kristen Johnson at The Scripps Research Institute in La Jolla, California, USA, to work on the role of proteostasis in diseases of aging and neurodegeneration. Our lab has performed HT screens in collaboration with Calibr, the drug discovery arm of TSRI, using lipid droplet clearance to identify small molecules that activate autophagy, and we are now characterizing their mechanisms of action and cellular targets in the context of disease-relevant models of neurodegeneration. We are committed to the development of new therapeutic strategies and to educating graduate students and postdoctoral associates to become successful, independent scientists in both academia and biotech/pharmaceutical research. We provide a diverse and collaborative research environment where scientists with distinct backgrounds can come together and share their collective expertise and experiences to drive forward both individual and team-based scientific projects. The postdoctoral associate will have full access to the extensive imaging and screening infrastructure, capabilities, and expertise available at Calibr.

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Dr. Ahmed H. Badran’s laboratory at Scripps Research seeks to hire 3-4 highly motivated Postdoctoral Associates to start in 2021-2022. The Badran Lab aims to address technical shortcomings in conserved cellular processes through innovative synthetic/chemical biology, directed evolution, genome editing and bioengineering approaches. Specifically, we aspire to develop tools for accelerating the evolution of macromolecular biosynthetic machinery and whole organisms. The recruited postdoctoral scholar(s) will lead diverse projects in the following areas: Targeted antibiotics discovery for microbiome regulation; Prediction of antimicrobial resistance modalities; Comprehensive strategies for genetic code expansion;

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Dr. Shannon Miller’s laboratory at Scripps Research is currently seeking talented Postoctoral Associate candidates. The Miller Lab uses directed evolution and engineering to develop novel technologies for biomolecule delivery, with a focus on improving in vivo delivery of genome editing agents. Areas of exploration encompass non-viral and viral approaches, including engineering viral payload (RNA/DNA/protein), increasing viral packaging limit, exploring natural diversity for new evolutionary starting points, and improving in vivo biomolecule stability. The candidate would lead efforts towards the creation of bacterial circuits for the improved activity of viral packaging proteins, development of technologies that enable packaging of non-canonical materials, and development and implementation of assays to evaluate the properties of the resulting biomolecules and vectors.

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5. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

Multiple fully funded positions for post-doctoral fellows are currently available in the Erb laboratory (Department of Chemistry, The Scripps Research Institute, La Jolla, CA). Our chemical biology group uses discovery chemistry, CRISPR/Cas9-based functional genetic screens, and advanced transcriptional genomics approaches to discover and study drug-like small molecules that therapeutically modulate chromatin regulation and mRNA transcription (see: https://www.erblab.scripps.edu/publications). We are seeking to hire multiple post-doctoral fellows to lead projects in ligand discovery, chromatin regulation, and cancer biology. Successful candidates will have laboratory experience in biology, chemistry, or computer science and be committed to working in a collaborative, multidisciplinary group with the goal of advancing new chemical tools, genetic insights, and therapeutic hypotheses.

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The laboratory of Professor CH Wong in the Department of Chemistry at Scripps Research has postdoctoral positions available in the following areas: chemoenzymatic synthesis of glycans and glycoproteins, glycosylation pathway engineering using CRISPR, development of glycan sequencing method with mass spectrometry, glycan-protein interaction in immunology. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair.

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Ghadiri Laboratory at the Scripps Research, Department of Chemistry, and the Skaggs Institute for Chemical Biology is currently seeking talented Postdoctoral Associate candidates with a strong background in biology, molecular biology, chemical biology, and/or biochemistry. The lab is developing new, general approaches to control the site and timing of enzyme activity. Enzymes have great potential as therapeutic and diagnostic agents due to their high specificity and catalytic activity, but the ability to better control the timing and location of enzyme function would enable the use of a wider variety of enzymes for therapeutic purposes. Our approach for enzyme programming relies on attaching an enzyme to its small-molecule inhibitor through an allosteric DNA tether. Upon interaction of the DNA tether with its complement strand, the ensuing conformational change activates the enzyme by dislodging the inhibitor from its active site. We have established the utility of DNA-programmed intrasterically-regulated enzymes in developing constructs for fast, sensitive, and PCR-independent isothermal detection of label-free nucleic acid sequences; carrying out complex logic operations; programming the activity of streptokinase, a clinically-used fibrinogen activator; and specifically killing targeted cancer cells. We are seeking qualified candidates who can join our multidisciplinary team of scientists to lead this broad research effort.

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Calibr is seeking exceptional Research Assistant or Associate candidates to join the protein expression team. This position will work within a small team of protein scientists and molecular biologists to produce proteins, plasmids, and viral vectors in support of R&D efforts on the next generation of novel medicines. This protein expression team will work as part of a team of interdisciplinary scientists to translate these findings into first in human clinical trials. Primary focus of the projects will be in immuno-oncology. This position will also have the unique opportunity to support a wide range of other projects at Calibr covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others. Calibr’s open lab space design and collaborative environment encourage the seamless flow of ideas within and between research groups. This position will receive hands-on training in translational research and is expected to bring exceptional proficiencies listed below at the start. Wet lab work is within the scope of this position with responsibilities including molecular cloning, protein expression and purification, and biophysical characterization of therapeutic candidates. Development of reports and internal presentation of data is within the scope of this position. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr family.

Last Application Date: Open Until Filled

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

Calibr is seeking a talented Research Associate or Assistant in the area of Immuno-Oncology. This position will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into first in human clinical trials. Specifically, projects will be focused on the development of a gene therapy referred to as chimeric antigen receptor T (CAR-T cell) and in the development of immunotherapies known as CD3 T cell recruiting bispecific antibody platforms. Both platform technologies have the potential to have curative responses in the clinic for cancer patients. While working within the scope of these projects, this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others. Calibr’s open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups. Publication in high impact journals and conference/meeting attendance will be highly encouraged as part of this position. This position will receive hands on training in translational research and is expected to bring the basic scientific proficiencies listed below at the start.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

We are looking for talented, highly motivated research associates with an interest is virology and immunology. The successful candidate will join a collaborative team investigating mechanisms of viral latency and developing novel antiviral treatments. The Research Assistant will work in close collaboration with a postdoctoral associate in their assigned team, as well as collaborators from other institutions. (Position supported by NIH funding.)

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

We are seeking a self-motivated Postdoctoral Associate with prior experience in molecular biology, biochemistry, immunology, and/or virology. The successful candidate will do interdisciplinary research in HIV vaccine development involving the following, recombinant DNA cloning and mutagenesis assays of antibody responses to vaccines in animal models cell culture; production of recombinant glycoproteins and antibodies.

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12. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The research project will focus on NK cell-based vaccination protocols and immunotherapies to prevent HIV infection, or attack latently HIV infected cells in models of humanized mice that harbor a functional human immune system. The work will be performed using in-house generated mice and humanized mice and requires expertise in the generation and experimental use of mice and humanized mice, cancer immunology, tissue culture, in vitro cellular assays such as quantitative PCR, killing assays, proliferation assays, flow cytometry, cellular and molecular biology. Positions require successful completion of required training courses (i.e. animal use, radioisotope training, BL-2 safety and general lab and chemical safety training). The successful candidate must be able to work independently, as well as in a team environment, pay close attention to detail and adhere to deadlines regularly. Excellent communication and interpersonal skills are essential. He/she will be detail oriented, self-motivated, a fast learner and possess excellent time management, organizational, written and verbal communication skills. The ability to take direction and use independent judgment to meet experimental goals and deadlines is required.

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The laboratory specifically focuses on immunologic mechanisms of ischemia-induced tissue injury with a particular interest in the innate immune system in kidney ischemia/reperfusion injury (IRI). The overall focus is to extend our understanding of the innate immune system as a key initiator of tissue injury after kidney ischemia and our work is aimed to provide new knowledge about how activation of both membrane-bound and intracellular PRRs contribute to ischemic kidney damage.

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide, accounting for over half a million deaths per year. Chronic infections with hepatitis B (HBV) and C (HCV) viruses have been recognized as main human liver carcinogens. Multiple non-viral factors have also been implicated in the development of HCC. The development of non-alcoholic steatohepatitis (NASH) and liver fibrosis represent high risk factors for HCC. Remarkably, we recently found that cyclophilin inhibitors suppress the development of viral-induced and non-viral-induced liver fibrosis and HCC in mouse models. However, their mechanisms of action are totally unknown. A postdoctoral position is immediately available to study the liver damage protective effects and mechanisms of action of cyclophilin inhibitors, both in vivo and in vitro, and to determine the potential of cyclophilin inhibitors as anti-liver damage drugs.

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15. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

SARS-CoV-2 is currently a major cause of death worldwide. Although vaccines are emerging, new therapies are urgently required. We recently developed a novel approach that permits the killing of SARS-CoV-2-infected cells while preserving non-infected cells. This new approach exploits the viral replication machinery (specifically the SARS-CoV-2 polymerase) to induce the expression of killer genes (diphtheria toxin fragment A) which triggers a rapid specific death of viral-infected cells, but not non-infected cells. A postdoctoral position is immediately available to further study the safety and efficacy of this novel “killing” approach both in vivo and in vitro using reporter (Luciferase, GFP, etc.) SARS-CoV-2 strains that permits in live monitoring in mice of the elimination of SARS-CoV-2 infected cells.

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16. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available immediately at Scripps Research in the Zwick lab.The successful candidate will contribute to the design of HIV vaccine candidates based on the envelope glycoprotein trimeric spike, identification of broadly neutralizing antibodies (bnAbs) from HIV-seropositive humans, and assessment of vaccine-induced bnAb responses in animal models. The candidate will be required to learn quickly and apply cutting-edge technologies to address critical problems in vaccine design. Candidate must be self-motivated, able to manage deadlines and solve problems. Excellent communication skills are essential. Candidate must work well independently and as part of a team. There will be opportunities to interact with experts in immunology, virology, bioinformatics, clinical researchers, and structural biologists. Additional training opportunities exist at Scripps in science writing and career development.

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17. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a talented self-driven Postdoctoral Associate with strong expertise in molecular biology, immunology, virology and biochemistry. The successful candidate is expected to perform a variety of scientific tasks directed at HIV vaccine development including the following Recombinant DNA technology; mutagenesis; cell culture Recombinant glycoprotein and antibody production Evaluation of vaccine candidates in various animal models

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

The Postdoctoral Research Associate will join the Law laboratory to manage and execute the recently funded NIH P01 Program “Broadly Effective HCV Vaccine”. The goal of this research program is to develop a vaccine candidate that can elicit potent and broad immune responses against the antigenically variable hepatitis C virus (HCV). The research program involves several laboratories at Scripps Research and the Southwest National Primate Research Center at San Antonio.

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, T cell immunology, and virus-host interactions. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The lab is interested in using a systems-level understanding of innate immunity, T cell biology, and virus-host interactions to discover novel druggable targets and small molecule agonists or inhibitors. The available postdoctoral training position will be focused on discovering novel regulators of human T cell differentiation (Treg/Th17 cell) and innate immune cell activation (inflammasome) involved in the development of autoimmune disease, infectious diseases, and cancer diseases. These studies will utilize systems biology including large-scale technologies (CRISPR/RNAi, proteomics/chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental immunology and more traditional cell & molecular biology and biochemistry-based approaches. The position will also have a good opportunity to work with pharmaceutical company partners to translate basic research into clinical applications.

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20. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Scripps Research is currently seeking a Postdoctoral Associate to join the Immunology and Microbiology Department of its La Jolla, California facility. The ideal candidate will have extensive experience in synaptic plasticity, field electrophysiology, and/or patch whole cell in brain slices and neuronal cells. Make Scripps Research your next step to advance your research training.

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

We are looking for talented, highly motivated post-doctoral candidates with a strong interest in basic virology and immunology. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on identifying cellular antiviral responses and molecular signatures linked to severe disease. These studies will utilize systems biology, including large-scale technologies (CRISPR/RNAi, proteomics/ chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental virology and more traditional cellular/molecular biology and biochemistry-based approaches. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.)

Last Application Date: Open Until Filled

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Research in the Voss laboratory is centered on the development of engineered B cell therapies to achieve an HIV functional cure. A position is immediately available for a highly motivated individual who is interested in improving B cell genome-editing approaches and characterizing the function of engineered cells in vivo in the mouse and non-human primate (NHP) animal models. The successful candidate will join a small team that will include doctoral students and research assistants who will work together to accomplish experimental goals. The applicant should have expert knowledge in immunology, relevant lab experience, and a track record of successful completion of work leading to high quality, peer-reviewed publication in scientific journals as first author. The candidate should enjoy participating in mentorship, have excellent experimental design, troubleshooting, communication, interpersonal, and organizational skills. A strong commitment to experimental goals, career goals and deadlines is required. Prior post-doctoral experience is not required for this position.

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology, and virus-host interactions. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on utilizing chemical biology and chemoproteomics tools to identify novel host-pathogen interactions that underlie viral infection and to develop novel therapeutic strategies to facilitate pandemic preparedness. Studies will focus on RNA viruses of pandemic potential, including influenza virus, coronavirus, flaviviruses, and filoviruses. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.) Please submit a CV/Biosketch and a Cover Letter addressing the following topics: (i) how does your research experience fit with our science? (ii) what can you uniquely bring to our research program & lab? (iii) and what are your long-term professional goals, and how can joining our team fit in these goals? and (iv) why you think you will be exceptionally successful in this role.

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24. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of six years. Experience with high-throughput assays, mouse models, mammalian metabolism, and adipose tissue biology preferred. Candidates should be independent, creative. They must have a strong interest and commitment to research, excellent organizational and communication skills, and a knack for teamwork.

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoctoral Associate to be co-mentored by the labs of Ben Cravatt and Ilia Droujinine. The Droujinine Lab aims to develop novel methods to identify and characterize novel secreted factors that coordinate organ and organism functions in homeostasis and disease in mammalian systems. To that end, we established an in vivo global proteomic platform to investigate secreted protein trafficking between organs. To learn more please visit www.scripps.edu/droujinine. The Cravatt Lab develops activity based protein profiling (ABPP) proteomics methods for basic biology and inhibitor discovery (www.scripps.edu/cravatt/). Ideal candidate will lead their own project, and perform mammalian cell culture, in vivo mouse experiments, quantitative TMT mass spectrometry proteomics, metabolomics, western blot, pulldowns, DNA cloning, immunostaining, confocal microscopy, high throughput screens, and bioinformatic data analysis. Significant emphasis is placed on the professional development of the Postdoctoral Associate. More information on the project will be discussed during the interview process.

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Martin-Fardon lab in the Department of Molecular Medicine at the Scripps Research Institute (La Jolla, CA), is seeking applications for a postdoctoral position. This solicitation seeks applicants who have an interest in alcohol use disorder as well as the interacting effects of alcohol and other abused substances, or who seek to investigate common mechanisms that may contribute to polysubstance abuse. Dr. Martin-Fardon projects are focused on 1) characterization of neural mechanisms of reward, dependence, withdrawal and relapse using pharmacology, in vivo neurochemistry, and molecular approaches; 2) behavioral analyses using animal models of binge-like drug consumption, escalation of drug intake which models compulsive consumption, negative reinforcement of drug taking during dependence, dysregulated stress responsivity and affect control during protracted withdrawal, impaired cognitive function and reinstatement of extinguished drug-seeking behavior.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral position is open in Dr. Wu’s lab at The Scripps Research Institute, the leading institute for biomedical research in USA, located in the sunny San Diego County. Research focuses on the mechanisms of DNA double-strand break (DSB) repair in mammalian cells. DNA double-strand break repair in mammalian cells with focus on both basic mechanisms and translational research We integrate multidisciplinary approaches combining EGFP-based reporter systems and cell-based assays with state-of-the-art technology in genome-wide analysis and mouse models to study DNA DSB repair mechanisms. We also explore synthetic lethality interactions of DNA damage response (DDR) proteins and collaborate with chemistry and structure labs to identify new drug leads for targeted cancer treatment.

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28. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available in the group of Drs. Lipton and Nakamura at the Neurodegeneration New Medicines Center and the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California. The successful candidate will join our team to investigate the pathophysiological roles of a posttranslational redox modification known as protein S-nitrosylation in a variety of neurodegenerative diseases. The Postdoctoral Associate will participate in research projects that involve i) a development of biomarkers for neurodegenerative diseases and ii) protein misfolding and spreading of pathology in neurodegenerative diseases. The successful candidate will assist in designing experiments, perform thorough data analyses and interpretation of results, and utilize sophisticated scientific lab techniques, such as confocal microscope and human induced pluripotent stem cell (hiPSC) cultures. Knowledge and techniques in molecular biology/biochemistry will be indispensable. Experience in mass spectrometry, bioinformatics, and ELISA is plus. The individual will pursue research projects solely and in collaboration with other lab members. The Postdoctoral Associate will supervise or provide work direction and training to other lab members. The individual will also write-up results for publication and attend scientific meetings to present results.

Last Application Date: Open Until Filled

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29. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The genomics-oriented cell biology laboratory of Dr. William E. Balch in the Department of Molecular Medicine at Scripps Research has an opening for a candidate with interest in understanding and treating mono and polygenic disease driven by genetic diversity in the population. Successful candidates will contribute to development and application of novel assays to assess impact of genetic diversity for different gene targets. Skill sets of interest include strong experience in tissue culture and the culture of human heterologous and primary cell lines including hiPSCs, familiarity with biochemical tools (SDS-PAGE, ELISA, etc.), knowledge and technical skills required for high-throughput/high content (imaging) screening (HTS/HCS) analyses. Additionally, an interest in the genetic diversity driving the biology of human health and disease with experience in Systems Biology and computational approaches for analysis of large datasets to explore basic mechanism and therapeutics will be helpful.

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30. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Scripps Research is currently seeking a Postdoctoral Associate to join the Molecular Medicine Department and Neuroscience Translational Center of its La Jolla, California facility. The selected candidate will plan and conduct novel research projects that involve a significant amount of cell culture, including human induced pluripotent stem cells (hiPSCs). The successful candidate will assist in designing experiments, perform thorough data analyses and interpretation of results, and operate sophisticated scientific lab equipment, including confocal microscope and/or patch-clamp electrophysiology and calcium imaging. Molecular biology and chemical biology knowledge and techniques will be indispensable. The individual will pursue research projects solely and in collaboration with other lab members and supervise or provide work direction and training to other lab members. The individual will also write-up results for publication and attend scientific meetings to present results. The specific research projects will involve investigations of neurodegenerative and neurodevelopmental diseases using hiPSC, cerebral organoid, and rodent model systems.

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Scripps Research is seeking a Postdoctoral Associate in the Molecular Medicine Department. This opportunity will study the function of the novel plasminogen receptor, Plg-RKT, in pulmonary immunology and asthma using new mouse models. In addition, cell biology approaches and single cell RNA Sequencing will be used to study the function of Plg-RKT in intracellular signaling.

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32. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate with experience on chemical biology, cell biology, immunology and experiences with murine models. Training in multi-color flow cytometry, fluorescent imaging, T-cell or cancer immunology is a plus.

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33. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate to support the Dr. Lotz lab. The candidate is expected to have knowledge and technical expertise in cell and molecular biology, cell culture, RNA isolation and analysis, protein isolation and analysis, statistics and basic knowledge in bioinformatics. The Lotz Laboratory is studying mechanisms and treatments of intervertebral disc degeneration (IDD) which affects a large population of older individuals and represents the major cause of back pain. The research on disease mechanisms uses human spines and genetic mouse models to investigate changes in cells, genes and proteins that develop during the aging process and the development of IDD. These studies examine cell function, RNA expression patterns using RNA sequencing and single cell RNA sequencing. The studies on treatments of IDD are using viral gene transfer of protective genes in rat models of IDD.

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34. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate. The lab focuses on the discovery of molecular and cellular mechanisms that are dysfunctional in musculoskeletal tissues during early stages of pathogenesis to create a foundation for therapeutic interventions to prevent disease onset and slow progression. The successful candidate will have a solid background in cell and molecular biology, with previous experience in target identification and validation. The candidate will lead in vitro and in vivo studies to identify and validate molecular targets that are essential for intervertebral disc homeostasis or that contribute to spine pathology, as part of a newly funded program in spine aging. Promising targets will be used in drug screening assays and/or gene therapy approaches. The candidate will work as part of a multidisciplinary and dynamic group with extensive experience with preclinical models for proof of concept validation of drug targets and drug candidates.

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35. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Encalada Laboratory in the areas of neurodegeneration, aging, and intracellular endolysosomal trafficking. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons, the role that defective transport and endolysosomal pathways play in neurodegeneration and aging, and the mechanisms of spreading of misfolded proteins involved in prion diseases, Alzheimer’s disease, and other tauopathies. The project will be the choice of the postdoctoral fellow, and could include mechanisms of aggregate spread in prion and tau models, mechanisms of formation of liquid-liquid phase separations in mouse and/or human neuronal disease models, mechanisms of neuronal toxicity in models of mechanisms of molecular motor regulation in neurons, and others. You will have the opportunity to do research in a superb intellectual setting at Scripps Research, by applying a combination of cell biology, genetics, biochemistry, and high-resolution quantitative light, super-resolution, and EM microscopy to your research in various model systems including mammalian neurons, mice, C. elegans, and/or in vitro reconstituted systems.

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36. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Fully-funded postdoctoral positions are available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated candidates who are interested in immune recognition and inhibition of microbial pathogens. Specifically, we are looking for candidates interested in working on projects focused on structure-based design of vaccine candidates, as well as antibody and small molecule therapeutics against microbial pathogens. Candidates with prior experience in structural biology with interests in virology, immunology, infectious disease, antibody and antigen characterization, and design/development of vaccines and therapeutics, are encouraged to apply. The Wilson laboratory research focuses on crystallographic studies of microbial pathogens, such as influenza virus, HIV-1, HCV, SARS-CoV-2 and P. falciparum malaria parasite. The major goals are to understand how the immune system combats viruses and other microbial pathogens through structural studies using high-resolution X-ray crystallography in concert with other biophysical and chemical biology approaches. We mainly focus on the analysis of antibody responses, definition of neutralizing epitopes, and use of that information to guide design of immunogens as potential vaccines as well as antibodies and small molecules as therapeutics.

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37. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Wilson laboratory research focuses on crystallographic studies of microbial pathogens, such as influenza virus, HIV-1, HCV, SARS-CoV-2 and P. falciparum malaria parasite. The major goals are to understand how the immune system combats viruses and other microbial pathogens through structural studies using high-resolution X-ray crystallography in concert with other biophysical and chemical biology approaches. We mainly focus on the analysis of antibody responses, definition of neutralizing epitopes, and use of that information to guide design of immunogens as potential vaccines as well as antibodies and small molecules as therapeutics. We also have interest in design of assays to aid in small molecule development against viruses, including influenza virus. These projects involve working within multi-disciplinary groups of collaborators at Scripps Research and across the nation to tackle current and emerging global health threats.

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38. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Mohammadi lab at Scripps Research is looking for highly motivated postdocs/senior scientists interested in genomic data analysis to join ongoing projects analyzing variation in non-coding genome, identifying genetic variation that contributes to disease, and combining multiple omics datasets. For more information, visit our lab website: http://pejlab.scripps.edu or contact Dr. Mohammadi directly via email pejman@scripps.edu.

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39. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in Dr. Lisa Racki’s Lab at the Scripps Research Institute in La Jolla, CA (rackilab.org) for a highly motivated scientist interested in bacterial chromatin and the role of chromatin in regulating bacterial phages. Specifically, this project will use phage and phage-derived tools to characterize the organization, structure, and dynamics of bacterial chromatin in the opportunistic human pathogen Pseudomonas aeruginosa. This project uses an integrative approach to study bacterial chromatin structure at multiple scales, from in vitro biochemistry, to quantitative single cell timelapse imaging using microfluidics, to macroscopic studies of biofilm communities.

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40. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

As a Postdoc, you will play a key role in processing terabytes of data from our partners, developing new AI algorithms and presenting the results in top academic journals. You will collaborate with AI experts and clinical professionals, leading the development of new solutions in Digital Medicine. You will be part of a team of data scientists, AI researchers, clinical and behavioral experts, and UX designers that collaborate on a wide range of innovative projects to improve healthcare. This role is a unique opportunity for someone with AI expertise to deepen her/his research in the healthcare domain. You will also have opportunities to build a research career by contributing to scientific publications and open source projects and through supervision of senior AI and clinical scientists.

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41. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Our lab is focused on the study of neural circuits and neuroendocrine signaling, with the goal of deciphering mechanisms underlying the bi-directional communication between the brain and the gut, an area with great potential for innovation and discovery. We utilize the C. elegans model system for its powerful molecular genetics and pathway discovery, and unraveled a novel brain-to-gut pathway with profound and unexpected orthology in mammals, which are now pursing in mouse models. We are seeking a motivated postdoctoral fellow to spearhead projects that will investigate the molecular and cellular basis underlying gut-brain signaling, and its impact on whole-body physiology and behavior. Our research program is uniquely juxtaposed at the intersection of molecular neuroscience and metabolism, and offers an exciting new perspective on the integrative biology of the gut-brain axis by leveraging the C. elegans model system.

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42. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

An opportunity exists for an accomplished researcher in computational genomics, statistical genetics, behavior genetics, and/or computational biology to deepen their knowledge in the context of the emerging area of addiction and behavioral genomics. The Peng lab in the Department of Neuroscience at Scripps Research in La Jolla, California is seeking a postdoctoral research associate. The ideal candidate would be a highly motivated researcher with a quantitative research background. The individuals who are interested in contributing to the following are encouraged to apply: cutting-edge research focusing on the dissection of the complex genetic and epigenetic basis of addiction and related human behaviors utilizing multi-omics data. The fellow will receive professional and career mentorship along with opportunities to advance their own expertise to become an independent investigator.

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43. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow position is available at the Cline Lab at the Dorris Neuroscience Center at the Scripps Research Institute in La Jolla, CA to conduct cutting edge studies on the roles of EVs in intercellular signaling between neural cells. The Dorris Neuroscience Center at the Scripps Research Institute is a vibrant collaborative neuroscience environment. The Postdoctoral Fellow will participate in studies examining EVs cargo and intercellular signaling capacity in hiPSC-derived neural cells. The postdoc will purify EVs released from iPSC-derived neural cell types, conduct imaging experiments to assess EV signaling bioactivity and contribute to molecular analysis of EV cargo. The candidate will also be actively involved in optimizing experimental design, data analysis, data interpretation and preparing presentations and papers.

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44. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

An NIH funded Postdoctoral Fellow position is available in a collaborative project involving the Cline, Maximov and Yates Labs at the Scripps Research Institute in La Jolla, CA. The goal of this project is to identify brain cell-type contributions to age- and AD-related synaptic and neuronal decline. We will use state-of-the-art proteomic methods together with diverse genetic, imaging, electrophysiology and behavioral strategies to assess structural and functional aspects of brain function. The Postdoctoral Fellow will determine protein dynamics in genetically defined brain cell types in animal models of Alzheimer’s Disease using bio-orthogonal non-canonical amino acid tagging (BONCAT) of newly-synthesized proteins and quantitative mass spectrometry, and conduct studies examining cellular and molecular mechanisms contributing to synaptic and neuronal function and plasticity. The candidate will be actively involved in optimizing experimental design, data analysis, data interpretation and preparing manuscripts and presentations.

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45. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Jin lab in the Departments of Neuroscience and the Dorris Neuroscience Center at Scripps Research seeks a postdoctoral fellow as part of a team of investigators studying the molecular and cellular mechanisms of brain development and disorders. The newly established group focuses on developing and applying genomic and molecular tools to approach psychiatric disorders and underlying molecular mechanisms (Jin et al, Science 2020). Collectively, our work encompasses many disciplines, including genetics and genomics, computational biology, molecular biology, neuroscience, synthetic biology, chemical biology, and bioengineering. Our lab is a fun, vibrant, fast-paced, results-driven, nurturing, and collaborative environment. It is a member of the Dorris Neuroscience Center at Scripps, and a part of the greater San Diego life science community including UCSD and Salk. The workplace culture is diverse, dynamic, progressive, and supports a healthy work-life balance. To support this mission, we strive to support diversity, intellectual curiosity, flexibility, and integrity.

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Scripps Research has huge a campus in California, USA and widely known as for its contribution in top notch education and research. The contribution of Scripps Research is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, etc..

1. Postdoctoral Associate – Super-Resolution Microscopy

Summary of Postdoctoral Fellowship:

Scripps Research is seeking a Postdoctoral Associate in the Scott Henderson Lab to support in the following areas: Undertake collaborative projects related to super-resolution microscopy. Assist with operations of super-resolution microscopy systems, including a newly installed MINFLUX system. Provide training on the operation of the super-resolution microscopes to Scripps Research scientists, faculty and staff.

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2. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A funded postdoctoral position is available in the Laboratories of Jeffery Kelly and Kristen Johnson at The Scripps Research Institute in La Jolla, California, USA, to work on the role of proteostasis in diseases of aging and neurodegeneration. Our lab has performed HT screens in collaboration with Calibr, the drug discovery arm of TSRI, using lipid droplet clearance to identify small molecules that activate autophagy, and we are now characterizing their mechanisms of action and cellular targets in the context of disease-relevant models of neurodegeneration. We are committed to the development of new therapeutic strategies and to educating graduate students and postdoctoral associates to become successful, independent scientists in both academia and biotech/pharmaceutical research. We provide a diverse and collaborative research environment where scientists with distinct backgrounds can come together and share their collective expertise and experiences to drive forward both individual and team-based scientific projects. The postdoctoral associate will have full access to the extensive imaging and screening infrastructure, capabilities, and expertise available at Calibr.

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3. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Dr. Ahmed H. Badran’s laboratory at Scripps Research seeks to hire 3-4 highly motivated Postdoctoral Associates to start in 2021-2022. The Badran Lab aims to address technical shortcomings in conserved cellular processes through innovative synthetic/ chemical biology, directed evolution, genome editing and bioengineering approaches. Specifically, we aspire to develop tools for accelerating the evolution of macromolecular biosynthetic machinery and whole organisms.

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4. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Ghadiri Laboratory at the Scripps Research, Department of Chemistry, and the Skaggs Institute for Chemical Biology is currently seeking talented Postdoctoral Associate candidates with a strong background in biology, molecular biology, chemical biology, and/or biochemistry. The lab is developing new, general approaches to control the site and timing of enzyme activity. Enzymes have great potential as therapeutic and diagnostic agents due to their high specificity and catalytic activity, but the ability to better control the timing and location of enzyme function would enable the use of a wider variety of enzymes for therapeutic purposes. Our approach for enzyme programming relies on attaching an enzyme to its small-molecule inhibitor through an allosteric DNA tether. Upon interaction of the DNA tether with its complement strand, the ensuing conformational change activates the enzyme by dislodging the inhibitor from its active site. We have established the utility of DNA-programmed intrasterically-regulated enzymes in developing constructs for fast, sensitive, and PCR-independent isothermal detection of label-free nucleic acid sequences; carrying out complex logic operations; programming the activity of streptokinase, a clinically-used fibrinogen activator; and specifically killing targeted cancer cells.

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5. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The laboratory of Professor CH Wong in the Department of Chemistry at Scripps Research has postdoctoral positions available in the following areas: chemoenzymatic synthesis of glycans and glycoproteins, glycosylation pathway engineering using CRISPR, development of glycan sequencing method with mass spectrometry, glycan-protein interaction in immunology. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair.

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6. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are seeking a talented Infectious Disease Postdoctoral Associate to join our multidisciplinary team working to discover and develop new drugs for neglected infectious tropical diseases. The primary focus of this position is to establish an in vitro drug discovery screening platform(s) to identify small-molecule compounds that modulate Leishmania spp parasite populations. Excitingly, screen hits will present ample opportunities to probe parasite biology and to generate novel chemical starting points for drug development. The position will require both independent as well as highly collaborative work, and results will be published in high-impact, peer-reviewed journals.

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7. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are seeking talented Medicinal and Synthetic Postdoctoral Associate candidates to join a dynamic, interdisciplinary team of scientists focused on early stage translational research. Postdoctoral researchers in the medicinal chemistry group will work as part of a team of scientists to synthesize and characterize small molecules that represent new therapeutic approaches to unmet medical needs. The researcher will be synthesizing and designing analogs designed to optimize the potency, pharmacokinetics, safety and in vivo efficacy of potential drug candidates. Work will be published in high-impact, peer-reviewed journals.

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8. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Chanda Lab has recently moved to The Scripps Research Institute (La Jolla, California), which is considered the most influential institution in the world for its innovation in science and medicine. Scientists in the institute’s five academic research departments expand basic knowledge and translate their findings into cutting-edge therapies. Our group has joined the Immunology and Microbiology Department, where we will continue to focus on the molecular mechanisms of virus-host interactions using advanced technologies such as CRISPR, RNAi, NGS, proteomics, chemical biology, and super-resolution microscopy, among others. We seek to understand a pathogen’s ability to exploit the host cellular machinery and evade innate immune defenses to drive viral pathogenesis.

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9. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Looking for an Electrophysiologist with extensive experience in synaptic plasticity, field electrophysiology, and/or patch whole cell in brain slices and neuronal cells.

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10. Postdoctoral Associate 

Summary of Postdoctoral Fellowship:

The research project will focus on NK cell-based vaccination protocols and immunotherapies to prevent HIV infection, or attack latently HIV infected cells in models of humanized mice that harbor a functional human immune system. The work will be performed using in-house generated mice and humanized mice and requires expertise in the generation and experimental use of mice and humanized mice, cancer immunology, tissue culture, in vitro cellular assays such as quantitative PCR, killing assays, proliferation assays, flow cytometry, cellular and molecular biology. Positions require successful completion of required training courses (i.e. animal use, radioisotope training, BL-2 safety and general lab and chemical safety training).

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11. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide, accounting for over half a million deaths per year. Chronic infections with hepatitis B (HBV) and C (HCV) viruses have been recognized as main human liver carcinogens. Multiple non-viral factors have also been implicated in the development of HCC. The development of non-alcoholic steatohepatitis (NASH) and liver fibrosis represent high risk factors for HCC. Remarkably, we recently found that cyclophilin inhibitors suppress the development of viral-induced and non-viral-induced liver fibrosis and HCC in mouse models. However, their mechanisms of action are totally unknown. A postdoctoral position is immediately available to study the liver damage protective effects and mechanisms of action of cyclophilin inhibitors, both in vivo and in vitro, and to determine the potential of cyclophilin inhibitors as anti-liver damage drugs.

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12. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

SARS-CoV-2 is currently a major cause of death worldwide. Although vaccines are emerging, new therapies are urgently required. We recently developed a novel approach that permits the killing of SARS-CoV-2-infected cells while preserving non-infected cells. This new approach exploits the viral replication machinery (specifically the SARS-CoV-2 polymerase) to induce the expression of killer genes (diphtheria toxin fragment A) which triggers a rapid specific death of viral-infected cells, but not non-infected cells. A postdoctoral position is immediately available to further study the safety and efficacy of this novel “killing” approach both in vivo and in vitro using reporter (Luciferase, GFP, etc.) SARS-CoV-2 strains that permits in live monitoring in mice of the elimination of SARS-CoV-2 infected cells.

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13. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available immediately at Scripps Research in the Zwick lab to do interdisciplinary research in HIV vaccine design.The successful candidate will contribute to the design of HIV vaccine candidates based on the envelope glycoprotein trimeric spike, identification of broadly neutralizing antibodies (bnAbs) from HIV-seropositive humans, and assessment vaccine-induced bnAb responses in animal models. The candidate will be required to learn quickly and apply cutting-edge technologies to address critical problems in HIV vaccine design. Candidate must be self-motivated, able to manage deadlines and solve problems. Excellent communication skills are essential. Candidate must work well independently and as part of a team. There will be opportunities to interact with experts in immunology, virology, bioinformatics, clinical researchers, and structural biologists. Additional training opportunities exist at Scripps in science writing and career development.

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14. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are seeking a talented self-driven Postdoctoral Associate with strong expertise in molecular biology, immunology, virology and biochemistry. The successful candidate is expected to perform a variety of scientific tasks directed at HIV vaccine development including the following; Recombinant DNA technology; mutagenesis; cell culture, Recombinant glycoprotein and antibody production

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15. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Postdoctoral Research Associate will join the Law laboratory to manage and execute the recently funded NIH P01 Program “Broadly Effective HCV Vaccine”. The goal of this research program is to develop a vaccine candidate that can elicit potent and broad immune responses against the antigenically variable hepatitis C virus (HCV). The research program involves several laboratories at Scripps Research and the Southwest National Primate Research Center at San Antonio.

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16. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, T cell immunology, and virus-host interactions. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The lab is interested in using a systems-level understanding of innate immunity, T cell biology, and virus-host interactions to discover novel druggable targets and small molecule agonists or inhibitors. The available postdoctoral training position will be focused on discovering novel regulators of human T cell differentiation (Treg/Th17 cell) and innate immune cell activation (inflammasome) involved in the development of autoimmune disease, infectious diseases, and cancer diseases. These studies will utilize systems biology including large-scale technologies (CRISPR/RNAi, proteomics/chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental immunology and more traditional cell & molecular biology and biochemistry-based approaches.

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17. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Scripps Research is currently seeking a Postdoctoral Associate to join the Immunology and Microbiology Department of its La Jolla, California facility. The ideal candidate will have extensive experience in synaptic plasticity, field electrophysiology, and/or patch whole cell in brain slices and neuronal cells. Make Scripps Research your next step to advance your research training. Click here to learn more about our Postdoctoral Program and Services: https://education.scripps.edu/postdoctoral/

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18. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are looking for talented, highly motivated post-doctoral candidates with a strong interest in basic virology and immunology. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on identifying cellular antiviral responses and molecular signatures linked to severe disease. These studies will utilize systems biology, including large-scale technologies (CRISPR/RNAi, proteomics/ chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental virology and more traditional cellular/molecular biology and biochemistry-based approaches. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.)

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19. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology, and virus-host interactions. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on utilizing chemical biology and chemoproteomics tools to identify novel host-pathogen interactions that underlie viral infection and to develop novel therapeutic strategies to facilitate pandemic preparedness. Studies will focus on RNA viruses of pandemic potential, including influenza virus, coronavirus, flaviviruses, and filoviruses. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. 

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20. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are looking for talented, highly motivated post-doctoral candidates with a strong interest in virology and drug development. The successful candidate will join a team investigating mechanisms of viral latency and developing novel antiviral treatment strategies. The project is part of the Martin Delaney Collaboratory for HIV Cure Research, a flagship NIH program that brings together a broad range of collaborators from academia and industry (ridhiv.org). The work will be highly translational, bridging mechanistic studies and drug discovery to develop immune restorative treatments and latency reversal strategies to cure HIV infection. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab.

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21. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Research in the Voss laboratory is centered on the development of engineered B cell therapies to achieve an HIV functional cure. A position is immediately available for a highly motivated individual who is interested in improving B cell genome-editing approaches and characterizing the function of engineered cells in vivo in the mouse and non-human primate (NHP) animal models. The successful candidate will join a small team that will include doctoral students and research assistants who will work together to accomplish experimental goals. The applicant should have expert knowledge in immunology, relevant lab experience, and a track record of successful completion of work leading to high quality, peer-reviewed publication in scientific journals as first author. The candidate should enjoy participating in mentorship, have excellent experimental design, troubleshooting, communication, interpersonal, and organizational skills. A strong commitment to experimental goals, career goals and deadlines is required. Prior post-doctoral experience is not required for this position.

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22. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The staff scientist will serve as the Cryo-electron Microscopy Liaison for structural biology studies at Scripps Research. The position will involve preparing samples for electron microscopy analyses, acquiring data, and performing image processing. The applicant will also be expected to perform some training of new users in cryo-EM methodologies, as well as contributing to ongoing technological cryoEM developments at Scripps Research. The EM Liaison will aid in assessing the viability of samples for structural investigation and advise users on how to optimize samples for EM analyses. The EM Liaison will perform pilot studies demonstrating feasibility on the 120 keV Spirit, 200 keV F20, or 200 keV Talos 200C, and perform subsequent high-resolution cryo-EM studies on promising samples in collaboration with users using the 200 keV Arctica or 300 keV Titan Krios.

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23. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Fully-funded postdoctoral positions are available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated candidates who are interested in immune recognition and inhibition of microbial pathogens. Specifically, we are looking for candidates interested in working on projects focused on structure-based design of vaccine candidates, as well as antibody and small molecule therapeutics against microbial pathogens. Candidates with prior experience in structural biology with interests in virology, immunology, infectious disease, antibody and antigen characterization, and design/development of vaccines and therapeutics, are encouraged to apply.

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24. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Wilson laboratory research focuses on crystallographic studies of microbial pathogens, such as influenza virus, HIV-1, HCV, SARS-CoV-2 and P. falciparum malaria parasite. The major goals are to understand how the immune system combats viruses and other microbial pathogens through structural studies using high-resolution X-ray crystallography in concert with other biophysical and chemical biology approaches. We mainly focus on the analysis of antibody responses, definition of neutralizing epitopes, and use of that information to guide design of immunogens as potential vaccines as well as antibodies and small molecules as therapeutics.

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25. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Mohammadi lab at Scripps Research is looking for highly motivated postdocs/senior scientists interested in genomic data analysis to join ongoing projects analyzing variation in non-coding genome, identifying genetic variation that contributes to disease, and combining multiple omics datasets. For more information, visit our lab website: http://pejlab.scripps.edu or contact Dr. Mohammadi directly via email pejman@scripps.edu.

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26. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available in Dr. Jiang Zhu’s laboratory for highly motivated candidates who are interested in vaccine development for viral (HIV, HCV, Ebola, RSV, Flu, MERS-CoV, and SARS-CoV-1/2) and non-viral (malaria and tuberculosis) pathogens. The Zhu lab has developed vaccine candidates for SARS-CoV-2 and HIV-1, which will start human trials in 2021 and 2022 with the sponsorship of Uvax Bio and the National Institute of Allergy and Infectious Diseases (NIAID), respectively. Research projects may involve, but are not limited to, (1) virology: infections and diseases caused by RSV, HIV, Ebola, and Coronavirus; (2) vaccine delivery: development of mRNA vaccines and viral vector-based vaccines; (3) structural biology: crystallographic and electron microscopic analyses of antibody/antigen complexes; and (4) immunology: immunological analysis of vaccine-induced response in animal models and humans.

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27. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in Dr. Lisa Racki’s Lab at the Scripps Research Institute in La Jolla, CA (rackilab.org) for a highly motivated scientist interested in bacterial chromatin and the role of chromatin in regulating bacterial phages. Specifically, this project will use phage and phage-derived tools to characterize the organization, structure, and dynamics of bacterial chromatin in the opportunistic human pathogen Pseudomonas aeruginosa. This project uses an integrative approach to study bacterial chromatin structure at multiple scales, from in vitro biochemistry, to quantitative single cell timelapse imaging using microfluidics, to macroscopic studies of biofilm communities.

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28. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available in Dr. Jiang Zhu’s laboratory for highly motivated candidates who are interested in vaccine development for viral (HIV, HCV, Ebola, RSV, Flu, MERS-CoV, and SARS-CoV-1/2) and non-viral (malaria and tuberculosis) pathogens. The Zhu lab has developed vaccine candidates for SARS-CoV-2 and HIV-1, which will start human trials in 2021 and 2022 with the sponsorship of Uvax Bio and the National Institute of Allergy and Infectious Diseases (NIAID), respectively. Research projects may involve, but are not limited to, (1) virology: infections and diseases caused by RSV, HIV, Ebola, and Coronavirus; (2) vaccine delivery: development of mRNA vaccines and viral vector-based vaccines; (3) structural biology: crystallographic and electron microscopic analyses of antibody/antigen complexes; and (4) immunology: immunological analysis of vaccine-induced response in animal models and humans.

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29. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of six years. Experience with high-throughput assays, mouse models, mammalian metabolism, and adipose tissue biology preferred. Candidates should be independent, creative. They must have a strong interest and commitment to research, excellent organizational and communication skills, and a knack for teamwork.

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30. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoctoral Associate to be co-mentored by the labs of Ben Cravatt and Ilia Droujinine. The Droujinine Lab aims to develop novel methods to identify and characterize novel secreted factors that coordinate organ and organism functions in homeostasis and disease in mammalian systems. To that end, we established an in vivo global proteomic platform to investigate secreted protein trafficking between organs. To learn more please visit www.scripps.edu/droujinine. The Cravatt Lab develops activity based protein profiling (ABPP) proteomics methods for basic biology and inhibitor discovery (www.scripps.edu/cravatt/).

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31. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Martin-Fardon lab in the Department of Molecular Medicine at the Scripps Research Institute (La Jolla, CA), is seeking applications for a postdoctoral position. This solicitation seeks applicants who have an interest in alcohol use disorder as well as the interacting effects of alcohol and other abused substances, or who seek to investigate common mechanisms that may contribute to polysubstance abuse. Dr. Martin-Fardon projects are focused on 1) characterization of neural mechanisms of reward, dependence, withdrawal and relapse using pharmacology, in vivo neurochemistry, and molecular approaches; 2) behavioral analyses using animal models of binge-like drug consumption, escalation of drug intake which models compulsive consumption, negative reinforcement of drug taking during dependence, dysregulated stress responsivity and affect control during protracted withdrawal, impaired cognitive function and reinstatement of extinguished drug-seeking behavior.

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32. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Postdoctoral position is open in Dr. Wu’s lab at The Scripps Research Institute, the leading institute for biomedical research in USA, located in the sunny San Diego County. Research focuses on the mechanisms of DNA double-strand break (DSB) repair in mammalian cells. DNA double-strand break repair in mammalian cells with focus on both basic mechanisms and translational research We integrate multidisciplinary approaches combining EGFP-based reporter systems and cell-based assays with state-of-the-art technology in genome-wide analysis and mouse models to study DNA DSB repair mechanisms. We also explore synthetic lethality interactions of DNA damage response (DDR) proteins and collaborate with chemistry and structure labs to identify new drug leads for targeted cancer treatment.

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33. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available in the group of Drs. Lipton and Nakamura at the Neurodegeneration New Medicines Center and the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California. The successful candidate will join our team to investigate the pathophysiological roles of a posttranslational redox modification known as protein S-nitrosylation in a variety of neurodegenerative diseases. The Postdoctoral Associate will participate in research projects that involve i) a development of biomarkers for neurodegenerative diseases and ii) protein misfolding and spreading of pathology in neurodegenerative diseases.

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34. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate to support the Dr. Lotz lab. The candidate is expected to have knowledge and technical expertise in cell and molecular biology, cell culture, RNA isolation and analysis, protein isolation and analysis, statistics and basic knowledge in bioinformatics. The Lotz Laboratory is studying mechanisms and treatments of intervertebral disc degeneration (IDD) which affects a large population of older individuals and represents the major cause of back pain. The research on disease mechanisms uses human spines and genetic mouse models to investigate changes in cells, genes and proteins that develop during the aging process and the development of IDD. These studies examine cell function, RNA expression patterns using RNA sequencing and single cell RNA sequencing. The studies on treatments of IDD are using viral gene transfer of protective genes in rat models of IDD.

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35. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate. The lab focuses on the discovery of molecular and cellular mechanisms that are dysfunctional in musculoskeletal tissues during early stages of pathogenesis to create a foundation for therapeutic interventions to prevent disease onset and slow progression. The successful candidate will have a solid background in cell and molecular biology, with previous experience in target identification and validation. The candidate will lead in vitro and in vivo studies to identify and validate molecular targets that are essential for intervertebral disc homeostasis or that contribute to spine pathology, as part of a newly funded program in spine aging. Promising targets will be used in drug screening assays and/or gene therapy approaches. The candidate will work as part of a multidisciplinary and dynamic group with extensive experience with preclinical models for proof of concept validation of drug targets and drug candidates.

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36. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Scripps Research is seeking a Postdoctoral Associate in the Molecular Medicine Department. This opportunity will study the function of the novel plasminogen receptor, Plg-RKT, in pulmonary immunology and asthma using new mouse models. In addition, cell biology approaches and single cell RNA Sequencing will be used to study the function of Plg-RKT in intracellular signaling.

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37. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate with experience on chemical biology, cell biology, immunology and experiences with murine models. Training in multi-color flow cytometry, fluorescent imaging, T-cell or cancer immunology is a plus.

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38. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Scripps Research is currently seeking a Postdoctoral Associate to join the Molecular Medicine Department and Neuroscience Translational Center of its La Jolla, California facility. The selected candidate will plan and conduct novel research projects that involve a significant amount of cell culture, including human induced pluripotent stem cells (hiPSCs). The successful candidate will assist in designing experiments, perform thorough data analyses and interpretation of results, and operate sophisticated scientific lab equipment, including confocal microscope and/or patch-clamp electrophysiology and calcium imaging. Molecular biology and chemical biology knowledge and techniques will be indispensable. The individual will pursue research projects solely and in collaboration with other lab members and supervise or provide work direction and training to other lab members.

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39. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Associate position is available in the Vogt lab for a highly talented and motivated individual with a strong background in the molecular biology of RNA . The focus of the lab is on long noncoding RNAs expressed in cancer and their relationship to known oncogenes such as MYC and PI3K. We are interested in studying RNAs which are expressed only upon gain of function in a driver oncoprotein. These lncRNAs are candidate markers of oncogenic transformation and in some cases may contribute to the oncogenic phenotype. An important goal of our work is the identification of lncRNAs that possess growth-promoting effects on cancer cells. As a tool, we use targeted Cas9 libraries. Once identified, the lncRNAs are characterized both functionally and structurally.

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40. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Encalada Laboratory in the areas of neurodegeneration, aging, and intracellular endolysosomal trafficking. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons, the role that defective transport and endolysosomal pathways play in neurodegeneration and aging, and the mechanisms of spreading of misfolded proteins involved in prion diseases, Alzheimer’s disease, and other tauopathies. The project will be the choice of the postdoctoral fellow, and could include mechanisms of aggregate spread in prion and tau models, mechanisms of formation of liquid-liquid phase separations in mouse and/or human neuronal disease models, mechanisms of neuronal toxicity in models of mechanisms of molecular motor regulation in neurons, and others.

Last Application Date: Open Until Filled

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41. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

As a Postdoc, you will play a key role in processing terabytes of data from our partners, developing new AI algorithms and presenting the results in top academic journals. You will collaborate with AI experts and clinical professionals, leading the development of new solutions in Digital Medicine. You will be part of a team of data scientists, AI researchers, clinical and behavioral experts, and UX designers that collaborate on a wide range of innovative projects to improve healthcare. This role is a unique opportunity for someone with AI expertise to deepen her/his research in the healthcare domain. You will also have opportunities to build a research career by contributing to scientific publications and open source projects and through supervision of senior AI and clinical scientists.

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42. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

Our lab is focused on the study of neural circuits and neuroendocrine signaling, with the goal of deciphering mechanisms underlying the bi-directional communication between the brain and the gut, an area with great potential for innovation and discovery. We utilize the C. elegans model system for its powerful molecular genetics and pathway discovery, and unraveled a novel brain-to-gut pathway with profound and unexpected orthology in mammals, which are now pursing in mouse models. We are seeking a motivated postdoctoral fellow to spearhead projects that will investigate the molecular and cellular basis underlying gut-brain signaling, and its impact on whole-body physiology and behavior.

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43. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

An opportunity exists for an accomplished researcher in computational genomics, statistical genetics, behavior genetics, and/or computational biology to deepen their knowledge in the context of the emerging area of addiction and behavioral genomics. The Peng lab in the Department of Neuroscience at Scripps Research in La Jolla, California is seeking a postdoctoral research associate. The ideal candidate would be a highly motivated researcher with a quantitative research background. The individuals who are interested in contributing to the following are encouraged to apply: cutting-edge research focusing on the dissection of the complex genetic and epigenetic basis of addiction and related human behaviors utilizing multi-omics data. The fellow will receive professional and career mentorship along with opportunities to advance their own expertise to become an independent investigator.

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44. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow position is available at the Cline Lab at the Dorris Neuroscience Center at the Scripps Research Institute in La Jolla, CA to conduct cutting edge studies on the roles of EVs in intercellular signaling between neural cells. The Dorris Neuroscience Center at the Scripps Research Institute is a vibrant collaborative neuroscience environment. The Postdoctoral Fellow will participate in studies examining EVs cargo and intercellular signaling capacity in hiPSC-derived neural cells. The postdoc will purify EVs released from iPSC-derived neural cell types, conduct imaging experiments to assess EV signaling bioactivity and contribute to molecular analysis of EV cargo. The candidate will also be actively involved in optimizing experimental design, data analysis, data interpretation and preparing presentations and papers.

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45. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

An NIH funded Postdoctoral Fellow position is available in a collaborative project involving the Cline, Maximov and Yates Labs at the Scripps Research Institute in La Jolla, CA. The goal of this project is to identify brain cell-type contributions to age- and AD-related synaptic and neuronal decline. We will use state-of-the-art proteomic methods together with diverse genetic, imaging, electrophysiology and behavioral strategies to assess structural and functional aspects of brain function. The Postdoctoral Fellow will determine protein dynamics in genetically defined brain cell types in animal models of Alzheimer’s Disease using bio-orthogonal non-canonical amino acid tagging (BONCAT) of newly-synthesized proteins and quantitative mass spectrometry, and conduct studies examining cellular and molecular mechanisms contributing to synaptic and neuronal function and plasticity. The candidate will be actively involved in optimizing experimental design, data analysis, data interpretation and preparing manuscripts and presentations.

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46. Postdoctoral Associate

Summary of Postdoctoral Fellowship:

The Jin lab in the Departments of Neuroscience and the Dorris Neuroscience Center at Scripps Research seeks a postdoctoral fellow as part of a team of investigators studying the molecular and cellular mechanisms of brain development and disorders. The newly established group focuses on developing and applying genomic and molecular tools to approach psychiatric disorders and underlying molecular mechanisms (Jin et al, Science 2020). Collectively, our work encompasses many disciplines, including genetics and genomics, computational biology, molecular biology, neuroscience, synthetic biology, chemical biology, and bioengineering.

Last Application Date: Open Until Filled

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