St. Jude Children’s Research Hospital has huge a campus in Tennessee, USA and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging.

Last Application Date: Open Until Filled

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Dr. Rohit Papu (Washington University in St. Louis).

Last Application Date: Open Until Filled

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive aspergillosis by identifying the molecular mechanisms underpinning antifungal resistance in the fungal pathogen Aspergillus fumigatus, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of A. fumigatus.

Last Application Date: Open Until Filled

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development. The candidate will be offered an excellent research environment to work on novel candidates identified from our own CRISPR screens and integrative analysis of multidimensional datasets.

Last Application Date: Open Until Filled

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5. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors. In this position, you will have a chance to lead your projects and mature into fully independent researcher. Successful candidate will gain an experience in genome wide technology, CRISPR-Cas editing, mouse models and stem cell biology.

Last Application Date: Open Until Filled

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system. We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes, and inflammatory cell death, PANoptosis).

Last Application Date: Open Until Filled

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in infectious disease therapeutics. This NIH sponsored training program has been designed to leverage the outstanding research infrastructure at St. Jude to train top-tier postdoctoral fellows with the necessary skills to lead independent research programs in the discovery of infectious diseases therapeutics including small molecule and vaccine candidates. Postdoctoral preceptors associated with the program are drawn from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences, bringing complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes structural biology, virology and bacteriology, microbial genomics, drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants.

Last Application Date: Open Until Filled

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The McKinnon lab within the CPNDR has postdoctoral positions to study the pathogenesis of pediatric neurological disease. The lab employs state of the art molecular neuroscience and multi-omics approaches to understand the mechanistic bases of various neurodegenerative syndromes arising from defective genome maintenance. Available postdoctoral projects include understanding the pathogenesis of genome instability induced neuroinflammation in a model of Aicardi Goutières syndrome (see Neuron, PMID: 34655526), the role of genome architecture in determining susceptibly of specific neural populations to genome damage (see Science Adv., PMID: 34910524) and elucidating the critical role of genome maintenance during neurogenesis (e.g see PMIDs 27630045, 30538199, 24793032, 26290337). Interested individuals with an extensive neuroscience background who are experienced in current molecular biology techniques are encouraged to apply. Please email a CV including the names of three references to: peter.mckinnon@stjude.org

Last Application Date: Open Until Filled

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

The McKinnon lab within the CPNDR has postdoctoral positions to study the pathogenesis of pediatric neurological disease. The lab employs state of the art molecular neuroscience and multi-omics approaches to understand the mechanistic bases of various neurodegenerative syndromes arising from defective genome maintenance. Available postdoctoral projects include understanding the pathogenesis of genome instability induced neuroinflammation in a model of Aicardi Goutières syndrome (see Neuron, PMID: 34655526), the role of genome architecture in determining susceptibly of specific neural populations to genome damage (see Science Adv., PMID: 34910524) and elucidating the critical role of genome maintenance during neurogenesis (e.g see PMIDs 27630045, 30538199, 24793032, 26290337). Interested individuals with an extensive neuroscience background who are experienced in current molecular biology techniques are encouraged to apply. Please email a CV including the names of three references to: peter.mckinnon@stjude.org

Last Application Date: Open Until Filled

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We are particularly interested in understanding how Sonic Hedgehog ligands use specialized filopodia called cytonemes to travel from their sites of synthesis to activate signaling on distantly localized target cells. Other focus areas in the laboratory include investigations centered on how Sonic Hedgehog signaling is activated in signal-receiving cells and how GLI transcriptional effectors are regulated to ensure appropriate transcriptional responses occur downstream of ligand. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

Last Application Date: Open Until Filled

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Yu Lab in the Department of Computational Biology is seeking outstanding candidates for a postdoctoral research associate focused on spatial omics and systems immunology. The Yu Lab is interested in developing systems biology algorithms, including NetBID (Du et al., Nature 2018), by integrating multi-omics data at both bulk and single-cell levels, to dissect the intracellular and intercellular network wiring and rewiring in healthy and disease conditions, as well as the underlying hidden drivers, and then translate the discoveries into potential clinical applications. The candidate will develop computational and systems biology approaches for network and hidden driver analysis from spatial omics data, single-cell omics data (e.g., scRNA-seq, scATAC-seq, single-cell proteomics, and spatial transcriptomics). The successful applicant will work in a dynamic environment, performing integrative analysis of multidimensional datasets in the context of basic immunology and cancer immunotherapy.

Last Application Date: Open Until Filled

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12. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The postdoctoral recruitment team within the Office of Academic Programs has a rare opening for a highly motivated, outgoing individual to assist with the recruitment of postdoctoral fellows. Responsibilities include processing applications, corresponding with applicants, scheduling interviews, and providing Memphis city tours. The successful candidate will also play a significant role in the planning and production of two annual scientific symposia, which bring graduate students to Memphis from across the United States.

Last Application Date: Open Until Filled

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Plummer Lab at St Jude’s is searching for a Postdoctoral Scientist with a strong background in tumor biology and genomics. This position will manage a team of laboratory technicians to process samples for profiling with single cell OMICs and spatial technologies. Our laboratory analyzes various clinical samples with emerging technologies and expect our analysis to lead to high profile publications in top tier scientific journals. The Plummer lab is a site for the Human Cell Atlas where we focus on understanding the development of disease by studying the cells of origin for neurodevelopmental disorders and breast/prostate/ovarian cancer. If you are interested in breakthrough research and implementing new research techniques, protocols and analyse/interpret data, come consider a close cooperation with Dr. Plummer and other Research Scientists including a high level Bioinformatics Team. Please send inquiries to jasmine.plummer@stjude.org

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St. Jude Children’s Research Hospital has huge a campus in Tennessee, USA and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital, Tennessee is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.

Last Application Date: Open Until Filled

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are interested in identifying novel genes and genetic variants that contribute to development of cancer and primary immunodeficiency. In 2015, we and others identified germline variants in ETV6, the gene encoding the essential hematopoietic transcription factor ETV6, in families affected by autosomal dominant thrombocytopenia and predisposition to B-acute lymphoblastic leukemia (B-ALL). We are now using human and mouse models to decipher how these germline ETV6 variants impact hematopoiesis and promote leukemogenesis. Towards this end, we have generated a knock-in mouse model harboring a heterozygous germline Etv6 variant that mimics a human variant observed in multiple kindreds. We are characterizing the hematopoietic phenotypes of these animals and examining the transcriptional mechanisms by which ETV6 regulates these processes. To model these cell compartments and perform assays in vitro, we also employ a number of cell lines including murine-derived HSPCs and pro-B cells, as well as human iPSCs. To study the role of ETV6 in malignancy, we have crossed the Etv6 variant mice with other mouse strains carrying known cooperating events identified in leukemia samples. Ultimately, our goal is to better understand how germline and somatic genetic events perturb key cellular and molecular pathways that then lead to leukemia.

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Dr. Kundu’s lab currently has an opening for a postdoctoral research fellow. The project will be to investigate the role of ulk1/2 in hematopoietic stem cells.

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

St. Jude is highly motivated to develop a novel research program to acquire cognitive and psychosocial data pre- and post-cancer therapy, for characterizing and predicting the effect of cancer and cancer-therapy on sensory, perceptual, cognitive and emotional aspects of brain function and behavior, and for developing interventions with brain modulation and stimulation techniques to reverse the adverse cognitive effect of pediatric cancer. This new program would heavily rely on the application of multimodal functional brain imaging which requires highly sophisticated imaging techniques, such as functional magnetic resonance imaging (fMRI), functional Near Infrared Spectroscopy (fNIRS), electro/magnetoencephalography (EEG/MEG) and brain stimulation combined with novel experimental paradigms. In addition, novel computational neuroscience and artificial intelligence methods including functional and effective connectivity, causality modeling, real-time imaging, brain-computer interfaces and neurofeedback would be key tools for scientific investigation and translational intervention in this new research program.

Last Application Date: Open Until Filled

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5. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship in the laboratory of Dr. Lillian Guenther in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Guenther’s research specifically focuses on identification of novel therapeutic targets in osteosarcoma. Dr. Guenther’s research has utilized genome-scale CRISPR screening and other complementary large-scale chemical and genomic screening modalities in multiple types of pre-clinical models to uncover novel dependencies, or critical osteosarcoma-specific survival genes. Research in the Guenther laboratory is designed to discover how such critical osteosarcoma dependency genes enable cell growth, with an eye towards clinical translation. We are specifically interested in enrichment for DNA damage repair and replication stress-related targets in this disease, and how this biology may be optimally exploited to better treat patients.

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Neumann lab is seeking candidates for a full-time postdoctoral research associate. The successful candidate will be responsible for developing novel imaging agents for use in Positron Emission Tomography (PET). Current projects in the Neumann lab focus on cancer, infectious disease, and oxidative stress imaging in various preclinical models. The ideal candidate should have a strong background in synthetic chemistry and radiochemistry, relevant cell culture training, some experience in small animal work, and an interest in in vivo imaging and translational science. The successful applicant will work as part of a collaborative team and will have access to a wide range of equipment, including a DOI PET/CT scanner, PET/MRI, focused ultrasound (FUS), on-site cyclotron, 18F and 11C synthesis modules, hot cells, liquid scintillation equipment, automated HPLCs and more. A dedicated cell and molecular biology laboratory, fully equipped for biological assays, will also be available. The candidate will also be cross-trained in Focused Ultrasound techniques to improve delivery of novel radiopharmaceuticals to the Central Nervous System.

Last Application Date: Open Until Filled

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the McKinney-Freeman laboratory of the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study the fundamental biology of hematopoietic stem cells (HSCs). HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Our major goals are to 1) illuminate the intrinsic and extrinsic factors that control the ability of HSC to home to, engraft, and repopulate the hematopoietic compartment after transplantation, 2) better understand the development of the HSC pool and bone marrow niche during early life and 3) uncover how chronic hematologic disease corrupts HSCs, with a particular focus on Sickle Cell Disease. We hope to leverage this knowledge to design therapies targeted at improving HSC transplantation for hematologic disease and gene therapy, as well as illuminate mechanisms of hematopoietic failure during chronic hematologic disease.

Last Application Date: Open Until Filled

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive aspergillosis by identifying the molecular mechanisms underpinning antifungal resistance in the fungal pathogen Aspergillus fumigatus, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of A. fumigatus.

Last Application Date: Open Until Filled

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

We are recruiting a postdoc for a structural biology project that investigates the role of water networks at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 4 years. We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. Despite the focus on computational structural biology, we will consider exceptional candidates with a suitable experimental background and a strong interest in protein dynamics, ligands and water.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children’s Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.

Last Application Date: Open Until Filled

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors. In this position, you will have a chance to lead your projects and mature into fully independent researcher. Successful candidate will gain an experience in genome wide technology, CRISPR-Cas editing, mouse models and stem cell biology.

Last Application Date: Open Until Filled

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12. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our recent findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.

Last Application Date: Open Until Filled

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Dr. Rohit Papu (Washington University in St. Louis).

Last Application Date: Open Until Filled

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development. The candidate will be offered an excellent research environment to work on novel candidates identified from our own CRISPR screens and integrative analysis of multidimensional datasets.

Last Application Date: Open Until Filled

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15. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow position to work on in vitro biophysics studies of the biology and biophysics of RNP granules. We will be addressing the biophysical and biological consequences of the network structure underlying stress granules. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Rohit Pappu (Washington University in St. Louis). The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.

Last Application Date: Open Until Filled

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16. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

St. Jude is seeking an outstanding candidate for postdoctoral fellow in multi-omics research. As a fellow you will join Dr. Qian Li’s lab in the Department of Biostatistics, providing computational or statistical support and developing analytical methods at the cutting edge of omics studies. You will benefit from access to unique datasets and expertise; top-ranked scientific environment; and superb benefits, mentoring, and professional development. One position is available with an appointment of two years. Dr. Qian Li’s methodological research focuses on (temporal) omics data, such as transcriptomics, metagenomics, and metabolomics. This postdoctoral fellow will develop innovative methods and tools for large-scale omics data analysis, including the integration of multi-omics data, in pediatric catastrophic disease. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS), and the largest pediatric cancer genome database, St. Jude Cloud.

Last Application Date: Open Until Filled

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17. Postdoctoral Fellowship

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes.

Last Application Date: Open Until Filled

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.

Last Application Date: Open Until Filled

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

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20. Biodiversity Postdoctoral Fellowship

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

Last Application Date: Open Until Filled

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A unique postdoctoral fellow position is available immediately in the joint laboratory of Dr. Christopher Tinkle, Department of Radiation Oncology, and Dr. Anang Shelat, Department of Chemical Biology and Therapeutics, to apply state-of-the-art chemical biology and bioinformatics methodologies across diverse pediatric malignancies to investigate the molecular consequences of defective DNA repair, and to target these deficits using small molecules. This project leverages the institution’s world class repository of patient derived xenograft models and associated genomic and proteomic data sets. This work will directly support the institution’s translational program, with the goal of identifying clinically actionable drug-drug and drug-radiation combination strategies.

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries. We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors.

Last Application Date: Open Until Filled

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021. The ideal candidate will demonstrate a willingness to learn new concepts and technical skills, but most importantly harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts. An ideal candidate will have a strong foundation in molecular biology-based techniques, experience/willingness to work with animal handling and procedures, and have a willingness to learn/work with complex computational software.

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24. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

The Bikoff lab (https://www.stjude.org/research/labs/bikoff-lab.html) is seeking a highly motivated postdoctoral researcher interested in studying neural circuitry in mice. The fundamental goal of our research is to understand how neural circuits control movement. We approach this from multiple perspectives, using cutting-edge technologies to analyze the molecular diversity of spinal interneurons, explore how descending systems in the brain convey information to the spinal motor system, and define the functional roles of spinal interneurons in generating behavior. These projects are highly multidisciplinary, taking advantage of a wide range of techniques including viral tracing, optogenetics and electrophysiology, whole-brain imaging, single-cell transcriptomics, and quantitative approaches to behavior. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, fun, and supportive environment that provides the freedom to independently develop a research project. The Bikoff lab is strongly committed to providing individual mentoring and training, as well as ongoing support at all stages of career development. Applications: Individuals with evidence of scientific accomplishment are encouraged to apply by sending their CV, a brief description of research interests, and contact information for three references to: jay.bikoff@stjude.org.

Last Application Date: Open Until Filled

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The department is seeking an outstanding postdoc fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer, mental health, and neurodegenerative diseases. Strong background in tensor analysis, functional data analysis, imaging data analysis, high dimensional data modeling, statistical learning, multivariate data analysis, survival data analysis, nonparametric statistics, statistical genetics, or deep learning are all considered as a plus. A recent Ph.D. in statistics, biostatistics, bioinformatics, computational biology, computer science or closely related field is required. Appointment is for two years. Applicants must have a strong computational background and demonstrate excellent written and verbal communication skills. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are very competitive. Send cover letter, CV, and three recommendation letters to Dr. Cai Li via e-mail at cai.li@stjude.org.

Last Application Date: Open Until Filled

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Outstanding candidates are invited to apply for a medical physics postdoctoral research associate in the Department of Radiation Oncology at St. Jude Children’s Research Hospital. In this two-year position, you will benefit from world-class resources and exceptional training in a top-ranked research environment while helping to advance treatment options for children with cancer.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking two outstanding candidates for postdoctoral fellowship positions in the HPV Cancer Prevention Program at St. Jude Children’s Research Hospital. The postdoctoral positions offer an intensive, mentored training experience in implementation science, community-engaged research, health equity, and cancer prevention through HPV vaccination. Postdoctoral fellows will be encouraged to support the research foci of the HPV Cancer Prevention Program and develop their own research programs in implementation science with a specific focus on HPV vaccination or other related topics (e.g., health equity, partner and engaged research approaches, building vaccine confidence, supporting vaccinations in clinical and community settings, public policy and advocation, communications, etc.) using implementation science frameworks.

Last Application Date: Open Until Filled

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28. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS).

Last Application Date: Open Until Filled

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29. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Last Application Date: Open Until Filled

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30. Postdoctoral Researcher

Summary of Postdoctoral Fellowship:

A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic and epigenetic underpinnings of chemotherapeutic drug resistance and relapse in childhood leukemia.

Last Application Date: Open Until Filled

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective. Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration, and polarization.

Last Application Date: Open Until Filled

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32. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.

Last Application Date: Open Until Filled

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33. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome).

Last Application Date: Open Until Filled

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34. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are recruiting a Postdoctoral Research Associate (a Cell and Molecular Biologist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The cell and molecular biology efforts are expected to synergize with our pharmacology, structural biology, and medicinal chemistry efforts and enable publication of impactful papers (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021; Nucleic Acids Res 50:3254, 2022). We work closely with the High Throughput Bioscience (HTB) Center (directed by Dr. Chen)

Last Application Date: Open Until Filled

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35. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are competitive. Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.

Last Application Date: Open Until Filled

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36. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity.

Last Application Date: Open Until Filled

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37. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study.

Last Application Date: Open Until Filled

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St. Jude Children’s Research Hospital has huge a campus in multiple states in USA and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital is not only limited to natural sciences but it also offers high quality research as well as higher education in bio-medical sciences, etc..

1. St. Jude Children’s Research Hospital Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes.

Last Application Date: Open Until Filled

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2. Postdoctoral Research Associate – Infectious Diseases

Summary of Postdoctoral Fellowship:

The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.

Last Application Date: Open Until Filled

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3. Postdoctoral Research Associate – Oncology Collaborative Research Program

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies.

Last Application Date: Open Until Filled

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4. Postdoctoral Research Associate – Oncology

Summary of Postdoctoral Fellowship:

Dr. Roberts’ research is highly regarded and he has been elected to the American Association of Clinical Research, the Society for Pediatric Research, the American Pediatric Society and American Association of Physicians. He is a passionate mentor and is fully committed to training the next generation of scientists. In addition to being the Director of the NCI designated St. Jude Comprehensive Cancer Center, Dr. Roberts leads a very successful well-funded team with postdoctoral scientists, graduate students, technologists, senior scientists, and a dedicated bioinformatician.

Last Application Date: Open Until Filled

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5. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.

Last Application Date: Open Until Filled

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6. Postdoctoral Research Associate – Oncology

Summary of Postdoctoral Fellowship:

The Nichols Lab at St. Jude Children’s Research Hospital is seeking a highly motivated Postdoctoral Fellow with interests and research experience in hematopoiesis, stem cell biology or leukemia modeling to carry out projects in cancer predisposition. We are interested in identifying novel genes and genetic variants that contribute to development of cancer and primary immunodeficiency. In 2015, we and others identified germline variants in ETV6, the gene encoding the essential hematopoietic transcription factor ETV6, in families affected by autosomal dominant thrombocytopenia and predisposition to B-acute lymphoblastic leukemia (B-ALL). We are now using human and mouse models to decipher how these germline ETV6 variants impact hematopoiesis and promote leukemogenesis.

Last Application Date: Open Until Filled

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7. Postdoctoral Research Associate – Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

Dr. Kundu’s lab currently has an opening for a postdoctoral research fellow. The project will be to investigate the role of ulk1/2 in hematopoietic stem cells.

Last Application Date: Open Until Filled

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8. Postdoctoral Research Associate – Diagnostic Imaging

Summary of Postdoctoral Fellowship:

We are looking for talented and motivated individuals to fill a post-doctoral researcher position to conduct research in functional MRI, real-time fMRI and related approaches to conduct cognitive neuroscience research in pediatric oncology. All candidates are expected to have completed PhD or equivalent doctoral degree in neuroscience, biomedical engineering, biomedical sciences, electronic/electrical engineering, physics, mathematics, computer science, psychology, or related areas. Other strong requirements include demonstrated experience and ability to conduct experimental work on humans or animal models, skills in analytical and computational techniques, and excellent written and spoken communication skills. Candidates with demonstration of peer-reviewed journal publications, patents and conference presentations are preferred.

Last Application Date: Open Until Filled

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9. Postdoctoral Research Associate – Diagnostic Imaging

Summary of Postdoctoral Fellowship:

St. Jude is highly motivated to develop a novel research program to acquire cognitive and psychosocial data pre- and post-cancer therapy, for characterizing and predicting the effect of cancer and cancer-therapy on sensory, perceptual, cognitive and emotional aspects of brain function and behavior, and for developing interventions with brain modulation and stimulation techniques to reverse the adverse cognitive effect of pediatric cancer. This new program would heavily rely on the application of multimodal functional brain imaging which requires highly sophisticated imaging techniques, such as functional magnetic resonance imaging (fMRI), functional Near Infrared Spectroscopy (fNIRS), electro/magnetoencephalography (EEG/MEG) and brain stimulation combined with novel experimental paradigms.

Last Application Date: Open Until Filled

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10. Postdoctoral Research Associate – Oncology

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship in the laboratory of Dr. Lillian Guenther in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Guenther’s research specifically focuses on identification of novel therapeutic targets in osteosarcoma. Dr. Guenther’s research has utilized genome-scale CRISPR screening and other complementary large-scale chemical and genomic screening modalities in multiple types of pre-clinical models to uncover novel dependencies, or critical osteosarcoma-specific survival genes. Research in the Guenther laboratory is designed to discover how such critical osteosarcoma dependency genes enable cell growth, with an eye towards clinical translation.

Last Application Date: Open Until Filled

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11. Postdoctoral Research Associate – Diagnostic Imaging

Summary of Postdoctoral Fellowship:

The Neumann lab is seeking candidates for a full-time postdoctoral research associate. The successful candidate will be responsible for developing novel imaging agents for use in Positron Emission Tomography (PET). Current projects in the Neumann lab focus on cancer, infectious disease, and oxidative stress imaging in various preclinical models. The ideal candidate should have a strong background in synthetic chemistry and radiochemistry, relevant cell culture training, some experience in small animal work, and an interest in in vivo imaging and translational science. The successful applicant will work as part of a collaborative team and will have access to a wide range of equipment, including a DOI PET/CT scanner, PET/MRI, focused ultrasound (FUS), on-site cyclotron, 18F and 11C synthesis modules, hot cells, liquid scintillation equipment, automated HPLCs and more. A dedicated cell and molecular biology laboratory, fully equipped for biological assays, will also be available.

Last Application Date: Open Until Filled

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12. Postdoctoral Research Associate – Radiation Oncology

Summary of Postdoctoral Fellowship:

The primary focus of this postdoctoral research associate position is on using Big Data analytics tools to improve treatment plan quality in proton therapy. We are especially interested in understanding the roles of linear energy transfer and treatment plan robustness.

Last Application Date: Open Until Filled

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13. Postdoctoral Research Associate – HPV Cancer Prevention

Summary of Postdoctoral Fellowship:

We are seeking two outstanding candidates for postdoctoral fellowship positions in the HPV Cancer Prevention Program at St. Jude Children’s Research Hospital. The postdoctoral positions offer an intensive, mentored training experience in implementation science, community-engaged research, health equity, and cancer prevention through HPV vaccination. Postdoctoral fellows will be encouraged to support the research foci of the HPV Cancer Prevention Program and develop their own research programs in implementation science with a specific focus on HPV vaccination or other related topics (e.g., health equity, partner and engaged research approaches, building vaccine confidence, supporting vaccinations in clinical and community settings, public policy and advocation, communications, etc.) using implementation science frameworks.

Last Application Date: Open Until Filled

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14. Postdoctoral Research Associate – Epidemiology & Cancer Control

Summary of Postdoctoral Fellowship:

Dr. Zhaoming Wang, a joint faculty member between St. Jude Department of Epidemiology and Cancer Control and the Department of Computational Biology, is seeking highly motivated and creative candidates for a fully supported postdoctoral fellow position to conduct high impact clinical research primarily in genetic epidemiology of cancers (childhood and subsequent adulthood cancers), biomarker discovery for treatment- and/or aging-related late effects of survivors of childhood cancer, and omics-based precision preventive medicine.

Last Application Date: Open Until Filled

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15. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Last Application Date: Open Until Filled

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16. Postdoctoral Research Associate – Pharmaceutical Sciences

Summary of Postdoctoral Fellowship:

A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics.

Last Application Date: Open Until Filled

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17. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Please apply here, in addition to specific postings, if you would like your CV reviewed by multiple faculty. Also apply here if you have been requested to do so by a recruiter. Minimum Education Only applicants within 6 to 12 months of completing a doctoral degree, or who have recently completed a PhD, PharmD, MD, or similar doctoral degree should apply.

Last Application Date: Open Until Filled

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18. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Dr. Rohit Papu (Washington University in St. Louis).

Last Application Date: Open Until Filled

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19. Postdoctoral Research Associate – Tumor Cell Biology

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development.

Last Application Date: Open Until Filled

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20. Postdoctoral Research Associate – Collaborative Research Program

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow position to work on in vitro biophysics studies of the biology and biophysics of RNP granules. We will be addressing the biophysical and biological consequences of the network structure underlying stress granules. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Rohit Pappu (Washington University in St. Louis). The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.

Last Application Date: Open Until Filled

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21. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer. The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.

Last Application Date: Open Until Filled

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22. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs.

Last Application Date: Open Until Filled

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23. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are competitive. Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.

Last Application Date: Open Until Filled

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24. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity.

Last Application Date: Open Until Filled

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25. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study.

Last Application Date: Open Until Filled

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26. Postdoctoral Research Associate – Chemical Biology & Therapeutics

Summary of Postdoctoral Fellowship:

A unique postdoctoral fellow position is available immediately in the joint laboratory of Dr. Christopher Tinkle, Department of Radiation Oncology, and Dr. Anang Shelat, Department of Chemical Biology and Therapeutics, to apply state-of-the-art chemical biology and bioinformatics methodologies across diverse pediatric malignancies to investigate the molecular consequences of defective DNA repair, and to target these deficits using small molecules. This project leverages the institution’s world class repository of patient derived xenograft models and associated genomic and proteomic data sets. This work will directly support the institution’s translational program, with the goal of identifying clinically actionable drug-drug and drug-radiation combination strategies.

Last Application Date: Open Until Filled

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27. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries. We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors.

Last Application Date: Open Until Filled

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28. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021.

Last Application Date: Open Until Filled

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29. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

The Bikoff lab (https://www.bikofflab.org/) is seeking a highly motivated postdoctoral researcher interested in using quantitative approaches to behavior, in vivo calcium imaging, and optogenetics/chemogenetics to study neural circuitry in mice. We aim to understand the functional organization of neural circuits that control movement, including how descending pathways from the brain interact with spinal circuits to implement motor output. The lab approaches this problem from multiple perspectives, using mouse genetics, single-cell transcriptomics, viral tracing and whole-brain imaging, and animal behavior to explore the role of molecularly discrete subsets of neurons in motor control.

Last Application Date: Open Until Filled

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30. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

The department is seeking an outstanding postdoc fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer, mental health, and neurodegenerative diseases. Strong background in tensor analysis, functional data analysis, imaging data analysis, high dimensional data modeling, statistical learning, multivariate data analysis, survival data analysis, nonparametric statistics, statistical genetics, or deep learning are all considered as a plus.

Last Application Date: Open Until Filled

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31. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate omics data related to innate immune signaling projects. The lab is particularly interested in dissecting signaling pathways and interactomes involved in innate immune responses and cell death (NLRs, inflammasomes). Knowledge and practical implementation of traditional machine learning and state-of-the-art deep learning techniques is essential. Understanding of working mechanisms of Alphafold2 and RoseTTAFold is highly appreciated. The tools and models built will be utilized to derive hypotheses which can be validated through in vitro and in vivo studies.

Last Application Date: Open Until Filled

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32. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system during viral infection. We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes) in response to viruses.

Last Application Date: Open Until Filled

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33. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.

Last Application Date: Open Until Filled

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34. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.

Last Application Date: Open Until Filled

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35. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details. St Jude Children’s Research Hospital offers an outstanding research environment, state-of-the-art scientific resources, and a robust community of talented, engaged, and collaborative investigators. We seek an intelligent, friendly, enthusiastic, committed, and capable individual to join our team.

Last Application Date: Open Until Filled

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36. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome).

Last Application Date: Open Until Filled

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37. Postdoctoral Research Associate – Chemical Biology & Therapeutic

Summary of Postdoctoral Fellowship:

We are recruiting a Postdoctoral Research Associate (either a Medicinal Chemist or a Cell and Molecular Biologist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models.

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St. Jude Children’s Research Hospital has huge a campus in Tennessee and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..

1. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Dr. Stan Pounds, a Member (Professor) in the St. Jude Department of Biostatistics, seeks a postdoc to pioneer the development and application of innovative data analysis methods in statistical cancer genomics and pharmacogenomics. In close collaboration with Drs. Charles Mullighan (St. Jude Pathology Department) and Jatinder Lamba (University of Florida College of Pharmacy), the successful applicant will develop and apply innovative statistical methods that integrate multiple forms of omic data (genomic, epigenomic, transcriptomic, proteomic, metabolomic) with multiple clinical outcomes (initial response, relapse-free survival, overall survival) to make fundamental biological discoveries that accelerate our progress towards curing childhood leukemias.

Last Application Date: Open until filled

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2. Postdoctoral Research Associate – Tumor Cell Biology

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development. The candidate will be offered an excellent research environment to work on novel candidates identified from our own CRISPR screens and integrative analysis of multidimensional datasets.

Last Application Date: Open until filled

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3. Postdoctoral Research Associate – Collaborative Research Program

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow position to work on in vitro biophysics studies of the biology and biophysics of RNP granules. We will be addressing the biophysical and biological consequences of the network structure underlying stress granules. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Rohit Pappu (Washington University in St. Louis). The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.

Last Application Date: Open until filled

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4. Postdoctoral Research Associate – Genetic Epidemiology and Pharmacogenomics

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoctoral Research Fellow to join the laboratory of Dr. Yadav Sapkota in the Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital. Successful candidates will work on projects related to pharmacogenomics of long-term toxicities of cancer therapy in childhood cancer survivors, supported by our new NIH R01 grant, in collaboration with Dr. Paul Burridge at Northwestern University (expert in using human induced pluripotent stem cells to study drug-induced toxicities). Specific research topics include 1) genetic association analyses (whole genome and whole exome sequence associations and polygenic risk scores) for various long-term health outcomes among survivors of European and African ancestries; 2) analyses of multi-omics (epigenomics, transcriptomics, proteomics, and metabolomics) and system genetics (e.g., eQTLs regulating molecular responses to cancer therapies in human induced pluripotent stem cells) data for elucidating molecular mechanisms for health outcomes; and 3) evaluating health disparities through pharmacogenomics.

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5. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes.

Last Application Date: Open until filled

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7. Postdoctoral Research Associate – Infectious Diseases

Summary of Postdoctoral Fellowship:

The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.

Last Application Date: Open until filled

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8. Postdoctoral Research Associate – Oncology Collaborative Research Program

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies.

Last Application Date: Open until filled

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9. Postdoctoral Research Associate – Oncology Collaborative Research Program

Summary of Postdoctoral Fellowship:

Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

Last Application Date: Open until filled

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10. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.

Last Application Date: Open until filled

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11. Postdoctoral Research Associate – Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

Dr. Kundu’s lab currently has an opening for a postdoctoral research fellow. The project will be to investigate the role of ulk1/2 in hematopoietic stem cells.

Last Application Date: Open until filled

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12. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. The department is seeking an outstanding postdoctoral fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer and mental health.

Last Application Date: Open until filled

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13. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate omics data related to innate immune signaling projects. The lab is particularly interested in dissecting signaling pathways and interactomes involved in innate immune responses and cell death (NLRs, inflammasomes). Knowledge and practical implementation of traditional machine learning and state-of-the-art deep learning techniques is essential. Understanding of working mechanisms of Alphafold2 and RoseTTAFold is highly appreciated. The tools and models built will be utilized to derive hypotheses which can be validated through in vitro and in vivo studies.

Last Application Date: Open until filled

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14. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system during viral infection. We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes) in response to viruses. The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. 

Last Application Date: Open until filled

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15. Postdoctoral Research Associate – Radiation Oncology

Summary of Postdoctoral Fellowship:

The primary focus of this postdoctoral research associate position is on using Big Data analytics tools to improve treatment plan quality in proton therapy. We are especially interested in understanding the roles of linear energy transfer and treatment plan robustness. As part of the Department of Radiation Oncology, the postdoctoral research associate will have access to world-class resources, including the world’s first proton therapy center with pencil-beam scanning technology that is designated solely for treating pediatric cancer, a detector-based spectral CT scanner that was the first in the world to be installed in a radiation oncology department, state-of-the-art 1.5T and 3T MR scanners, and a recently installed digital PET/CT scanner.

Last Application Date: Open until filled

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16. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology approaches. In particular, we study heterochromatin formation and the chromatin-modifying proteins involved in this process. We use cryo-EM methodologies to examine processes involved in chromatin organization and also apply genetics and molecular biology approaches to investigate heterochromatin formation in fission yeast.

Last Application Date: Open until filled

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17. Postdoctoral Research Associate – Epidemiology & Cancer Control

Summary of Postdoctoral Fellowship:

Dr. Zhaoming Wang, a joint faculty member between St. Jude Department of Epidemiology and Cancer Control and the Department of Computational Biology, is seeking highly motivated and creative candidates for a fully supported postdoctoral fellow position to conduct high impact clinical research primarily in genetic epidemiology of cancers (childhood and subsequent adulthood cancers), biomarker discovery for treatment- and/or aging-related late effects of survivors of childhood cancer, and omics-based precision preventive medicine. You will have the opportunity to work with large-scale whole-genome sequencing, whole-exome sequencing, epigenetic profile, and RNA sequencing data for a well-established cohort of childhood cancer survivors with clinically assessed rich set of phenotypes including subsequent neoplasms.

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18. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Last Application Date: Open until filled

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19. Postdoctoral Research Associate – Pharmaceutical Sciences

Summary of Postdoctoral Fellowship:

A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics.

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20. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Please apply here, in addition to specific postings, if you would like your CV reviewed by multiple faculty. Also apply here if you have been requested to do so by a recruiter.

Last Application Date: Open until filled

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21. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project.

Last Application Date: Open until filled

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22. Postdoctoral Research Associate – Chemical Biology & Therapeutic 

Summary of Postdoctoral Fellowship:

We are recruiting a Postdoctoral Fellow (Medicinal Chemist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The medicinal chemistry efforts are expected to synergize with our pharmacology and structural biology efforts and enable publication of impactful papers (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021).

Last Application Date: Open until filled

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23. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs.

Last Application Date: Open until filled

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24. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.

Last Application Date: Open until filled

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25. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity.

Last Application Date: Open until filled

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26. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer. The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.

Last Application Date: Open until filled

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27. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study.

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28. Postdoctoral Research Associate – Chemical Biology & Therapeutics

Summary of Postdoctoral Fellowship:

A unique postdoctoral fellow position is available immediately in the joint laboratory of Dr. Christopher Tinkle, Department of Radiation Oncology, and Dr. Anang Shelat, Department of Chemical Biology and Therapeutics, to apply state-of-the-art chemical biology and bioinformatics methodologies across diverse pediatric malignancies to investigate the molecular consequences of defective DNA repair, and to target these deficits using small molecules. This project leverages the institution’s world class repository of patient derived xenograft models and associated genomic and proteomic data sets. This work will directly support the institution’s translational program, with the goal of identifying clinically actionable drug-drug and drug-radiation combination strategies.

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29. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries. We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors.

Last Application Date: Open until filled

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30. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021.

Last Application Date: Open until filled

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31. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

We aim to understand the functional organization of neural circuits that control movement, including how descending pathways from the brain interact with spinal circuits to implement motor output. The lab approaches this problem from multiple perspectives, using mouse genetics, single-cell transcriptomics, viral tracing and whole-brain imaging, and animal behavior to explore the role of molecularly discrete subsets of neurons in motor control. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, interactive, and supportive environment that provides the freedom to independently develop a research project.

Last Application Date: Open until filled

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32. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective. Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation.

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33. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.

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34. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details.

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35. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization.

Last Application Date: Open until filled

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