National Cancer Institute has huge a campus in USA and widely known as for its contribution in top notch education and research. The contribution of National Cancer Institute is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral fellow position is available in the Gonatopoulos-Pournatzis lab within the RNA Biology Laboratory at the National Cancer Institute (NCI) in Frederick, MD at the National Institutes of Health (NIH). The research in the lab focuses on characterizing regulatory networks that control alternative splicing and on the systematic interrogation of transcript isoforms with critical roles in normal physiology and disease states. We address these questions by developing and applying state-of-the art CRISPR-based functional genomics screening tools in combination with computational, molecular biology and biochemical approaches as well as generation of animal models.

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Center for Immuno-Oncology (CIO) functions as a multidisciplinary and interdisciplinary translational and clinical research programmatic effort with the goal of developing novel immunotherapies for cancer. The CIO focuses on the development of novel immunotherapeutics for human cancer, not only as monotherapies, but more importantly, in combination with other immune-mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Within this effort are several research groups, a clinical trials group, and multiple collaborations with intramural and extramural scientific and clinical investigators and with investigators in the private sector. The program takes advantage of the uniqueness of the NCI intramural program in that it spans high-risk basic discovery research in immunology genomics and tumor biology, through preclinical translational research, to paradigm-shifting clinical trials. Focus is placed on the design and development of novel ‘off-the-shelf’ recombinant (rec.) immunotherapeutics that can be used in clinical studies at numerous institutions. A major strength of the program is the rapid translation of preclinical studies to hypothesis-generating clinical trials.

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3. Clinical Fellow – Surgical Oncology, Fellowship, Training

Summary of Postdoctoral Fellowship:

The Fellowships in Surgical Oncology Research and Cancer Immunotherapy at the National Cancer Institute (NCI) encompass two time-honored programs combining bench-side research in surgical oncology with training in clinical research through direct patient care. The unique environment of the Clinical Center at the National Institutes of Health (NIH) allows for direct bedside-to-bench and bench-to-bedside translational research under the direction of world leaders in surgical oncology. The two-year Surgical Oncology Research Fellowship includes 18 months of bench laboratory experience in one of the many NCI laboratories and 6 months of clinical rotations over three surgical oncology subspecialties. Clinical research opportunities are available over the entire two-year period. Additional optional research years may be available. The three-year Fellowship in Cancer Immunotherapy incorporates an additional year of clinical experience in the management of patients undergoing cell-based cancer immunotherapy developed in the Surgery Branch of the NCI. Basic science experience is dedicated to work in one of the multiple immunotherapy laboratories within the NCI and participation in this fellowship is complemented by additional didactic opportunities in cancer immunotherapy.

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated postdoctoral fellow, preferably a recent graduate (Ph.D. and/or M.D.), with a background in Cancer Biology/Molecular and Cellular Biology to join the Translational Research Program at the Neuro-Oncology Branch, CCR, NCI, NIH. The mission of he Translational Research Program is to develop hypothesis-driven laboratory projects, leading to testing in preclinical models, and ultimately developing clinical trials based on these preclinical studies to determine predictors and mechanisms of treatment responses or resistance. The ideal candidate is expected to take an active role in designing and implementing preclinical experiments in investigating glioma tumor biology and drug development for the management of glioma and its tumor microenvironment.

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5. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Mouse Cancer Genetics Program, CCR, NCI (Frederick, MD) is now recruiting a postdoctoral fellow. The successful candidate should have a background in neurobiology and/or physiology and basic expertise in molecular biology, cell biology, immunohistochemistry, biochemistry and imaging. Candidates with expertise in electrophysiology are also encouraged to apply. Our group studies the biology of neurotrophin and Trk receptor’s function by using both in vitro and in vivo approaches. The current research emphasis is on understanding the molecular mechanisms underlying Trk receptor’s physiological functions. In addition, we are attempting to identify new signaling pathways activated by truncated Trk receptors.

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Osteosarcoma and other sarcomas are resistant to immunotherapies because they are generally “cold” tumors. Our recent studies have identified a surface protein that regulates osteosarcoma cell-host interaction. Preliminary data show that genetic deletion of this protein in osteosarcoma cells enhances infiltration of anti-tumor immune cells in the tumor and subsequent tumor reduction. However, the underlying mechanism is unknown. The successful candidate will investigate the mechanism using single-cell sequencing and high-throughput flow cytometry at the Laboratory of Cancer Biology and Genetics, NCI, NIH (Bethesda campus). The overarching goal is to identify new strategies to increase the efficacy of immunotherapy in osteosarcoma and other sarcomas.

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7. Senior Investigator – Basic and translational cancer research

Summary of Postdoctoral Fellowship:

The National Cancer Institute (NCI) is seeking outstanding, internationally recognized and visionary scientists to lead independent research groups to conduct cutting-edge cancer research in the NCI Center for Cancer Research (CCR). All areas relevant to basic and translational cancer research will be considered. These positions are part of the National Institutes of Health’s (NIH) world-class intramural research program (IRP) and equivalent to a tenured academic associate professor or professor. Successful candidates will be eligible to be appointed as an NIH tenured Senior Investigator and are expected to lead a world-class research program, supported by generous stable resources including access to a wide range of NCI technology platforms and interdisciplinary collaborations within NCI, as well as at NIH and its Clinical Center.

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Dr. Chengkai Dai’s laboratory at the Mouse Cancer Genetics Program, CCR, NCI, has one postdoctoral fellowship (visiting fellow) position open. The candidate will participate in projects that elucidate proteomic instability of cancer (particularly, tumor-associated amyloidogenesis) and anti-amyloid effects of HSF1. HSF1, the master transcriptional regulator of the heat-shock or proteotoxic stress response, plays a critical role in preserving proteomic stability under stress conditions. Contrasting with its dispensability for primary cells, cancerous cells become dependent on HSF1 for their growth and survival, a phenomenon referred to as “non-oncogene addiction”. Revealed by Project Achilles, numerous human cancer cell lines depend on HSF1.

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

A postdoctoral fellowship is available to study the role of pericytes to promote pre-metastatic niche formation and metastatic progression in the laboratory of Meera Murgai, Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, Maryland. The postdoctoral fellow will focus on interrogating pericyte heterogeneity and plasticity in the metastatic microenvironment, following up on work published in our Nature Medicine 2017 article. The post-doctoral fellow will be trained in techniques related to cancer biology, vascular biology and computational analysis of gene expression, epigenetic, and microscopy datasets to further our understanding of the metastatic microenvironment in experimental models and patient data. Extra consideration will be given to candidates with an interest in the relationship between epigenetic states and cell fate decisions.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

Two postdoctoral positions are available at the Genomic Stability and Metabolism Group (PI: Urbain Weyemi, Ph.D.) within the Developmental Therapeutics Branch, CCR, NCI in Bethesda, Maryland. Our group aims to understand the dialogue between genomic instability and metabolism in human diseases, particularly in cancer and neurodegeneration. We apply multiple genomics and metabolomics tools to assess how changes in genome repair pathways affect metabolic abilities of cancer cells. Our goal is to understand how cancer cells undergo metabolic reprogramming to escape therapeutic agents targeting DNA repair.

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

Multiple postdoctoral and Ph.D. student positions are available under the supervision of Dr. Mikhail Kolmogorov at the CCR, NCI, NIH. The Kolmogorov Lab is part of the Cancer Data Science Laboratory, a new initiative dedicated to translational omics research and tightly integrated with basic and translational projects at the NCI. The general focus of Dr. Kolmogorov’s group is computational genomics – algorithms, mathematical models and tools aimed to answer fundamental questions about living systems through the analysis of large-scale genomic data. The group is currently seeking applicants with an interest in developing and/or applying computational methods for cancer genomics and metagenomics. Possible projects include but are not limited to: analysis of complex chromosomal rearrangements in cancer, haplotype-resolved assembly of complex polyploid genomes, deconvolution of complex metagenomic communities, genome graph representations, genomic analysis of large patient cohort data. We are also open to other computational projects candidates would like to propose, as long as they fit our general direction.

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12. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the laboratory of Dr. Jing Huang, Senior Investigator, in the Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD. The RUNX family proteins are transcription factors that regulate diverse and tissue-specific pathways. Recent studies show that RUNX proteins have important roles in breast cancer and osteosarcoma etiology. The successful candidate will investigate molecular and cellular mechanisms underlying the functions of RUNX protein in either breast cancer or osteosarcoma, depending on her/his interest and previous background/training. The overarching goal is to identify new translational strategies to treat breast cancer and osteosarcoma based on the results of this study.

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13. Staff Scientist – Behavioral health, psychosocial research

Summary of Postdoctoral Fellowship:

The Psychosocial Support and Research Program in the Behavioral Health Core of the Pediatric Oncology Branch, (POB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) invites applicants for a full-time staff scientist position, preferably mid-career. This position utilizes a scientist-practitioner model, bridging clinical practice with a robust psychosocial research program. The Psychosocial Support and Research Program is dedicated to providing behavioral health care to children, teens, and young adults with cancer and other chronic medical conditions who are enrolled on natural history studies, clinical treatment trials, and psychosocial interventions at the NIH Clinical Center. We work collaboratively with physicians, psychologists, social workers, recreation therapists, palliative care specialists and allied professionals to provide comprehensive care in the form of quality clinical services to children and their family members enrolled on CCR clinical trials to help enhance coping and adaptation.

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at the DNA Replication Group (PI: Mirit I. Aladjem, Ph.D.), in collaboration with the Molecular Pharmacology Group (PI: Dr. Yves Pommier, M.D., Ph.D.) of the Developmental Therapeutics Branch, CCR, NCI in Bethesda, Maryland. Our groups aim to understand mechanistic insights into cellular networks that modulate cancer cell proliferation and identify targets for intervention in cancer. Since many regulatory feedback pathways are deregulated in cancer cells, the results of our studies will help our understanding of cancer biology and the mechanisms underlying therapeutic strategies.

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15. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of Dr. Zheng-Gang Liu’s lab, Laboratory of Immune Cell Biology, CCR, NCI, Bethesda, MD, to study the molecular mechanisms of cell death, inflammation, onco-immunology, and cancer development.

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16. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral training positions are currently available in the Vaccine Branch, CCR, National Cancer Institute, in Frederick, MD. The positions are in the group headed by Barbara K. Felber, Ph.D., whose lab focuses on nucleic acid vaccines against AIDS and COVID-19 and on cytokines for vaccine and cancer.

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17. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Seeking a Post-Doctoral Fellow for the Surgery Branch under the supervision of the Branch Chief, Steven A. Rosenberg, M.D., Ph.D.. The Surgery Branch is a combined laboratory and clinical research unit devoted to the development of innovative cancer immunotherapies and their subsequent translation to the treatment of patients with cancer. Candidates should be completing or have completed a doctoral degree in a scientific field related to immunology.

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

Fully funded postdoctoral and research fellow positions for experimental and computational biologists are available in Dr. Michael Aregger’s Functional Genomics Section within the Molecular Targets Program at the CCR, NCI, NIH. Our group’s research focuses on how cancer cells rewire gene expression and metabolism to adapt to changing environmental conditions. We apply CRISPR-based genome engineering tools and functional genomics approaches to reveal genetic interactions and cancer dependencies, and to identify regulators of metabolic plasticity in cancer cells. Our lab focuses on developing innovative genetic screening approaches and we have access to state-of-the art facilities including next-generation sequencing, single-cell analysis platforms, mass spectrometry, flow cytometry, natural products and synthetic compound libraries, and animal facilities.

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Yoo laboratory, in the Chemical Biology Laboratory, CCR, NCI, has an opening for a postdoctoral fellow. The goal of our research project is to study functional proteases that play important roles as instigators and regulators of immune responses and understand how they shape the tumor microenvironment and dictate the fate of tumor cells. Our research focuses on the development and application of chemical strategies that allow kinetic and dynamic measurement of the network of protease activities. We use our expertise in synthetic chemistry to synthesize small molecules and peptidomimetics to probe and inhibit the activity of proteases and utilize biochemistry, structure biology, molecular biology, and chemical proteomics to characterize the protease-ligand interactions.

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20. Staff Scientist – Behavioral science, psychosocial research, pediatric

Summary of Postdoctoral Fellowship:

The Psychosocial Support and Research Program in the Behavioral Health Core of the Pediatric Oncology Branch, (POB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) invites applicants for a full-time staff scientist position, preferably mid-career. This position utilizes a scientist-practitioner model, bridging clinical practice with a robust psychosocial research program. The Psychosocial Support and Research Program is dedicated to providing behavioral health care to children, teens, and young adults with cancer and other chronic medical conditions who are enrolled on natural history studies, clinical treatment trials, and psychosocial interventions at the NIH Clinical Center. We work collaboratively with physicians, psychologists, social workers, recreation therapists, palliative care specialists and allied professionals to provide comprehensive care in the form of quality clinical services to children and their family members enrolled on CCR clinical trials to help enhance coping and adaptation.

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair proteins in a variety of cancers that include leukemias and breast cancers, using mouse models. The position will emphasize efforts to understand gene regulation, chromatin, regulatory and structural variation and its relation to cancer. The position will involve analysis of applications involving high-throughput DNA sequencing methods for a variety of assays, including RNA-seq, exon sequencing, ATAC-seq, DNase-seq, ChIP-seq, END-seq and newer, cutting-edge methodologies that are in development.

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) to study the mechanisms involved in DNA double-strand break repair, with a focus on understanding the influence of chromatin structure on the maintenance of genome integrity and their roles in a variety of cancers using cutting-edge cellular, molecular, and genomic tools.

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD, is actively recruiting for a staff scientist to work in the Cancer Molecular Pathology section headed by Frederic G. Barr, MD PhD. This research section uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study genetic and epigenetic alterations in cancer. By initially focusing on specific cancer types, such as the rhabdomyosarcoma family of myogenic soft tissue cancers, this research laboratory is investigating the molecular basis, biological consequences and clinical significance of chromosomal translocations, amplification events, point mutations and methylation changes in these cancers. The methodologies, reagents and concepts from these studies are then being applied to address these issues in other relevant cancer categories.

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24. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The NCI/CCR/Comparative Oncology Program is seeking highly motivated and collaborative candidates with a background in molecular biology and/or comparative oncology to use a multiprong experimental approach, including in vitro and in vivo modeling. The successful candidate will support studies in metastatic osteosarcoma (OS) initiated under the umbrella of the DOG2 project (Deciphering the Osteosarcoma Genome of the Dog). DOG2 is a multi-omic approach which leverages our access to high-quality clinically-annotated canine OS specimens collected during the last 4 years of clinical trial activities in >400 dogs with OS. Taking advantage of these invaluable tissue resources, current projects include: 1) a NanoString examination of primary:metastatic pairs using the Canine IO panel, 2) investigation of cellular senescence and the senescence-associated secretory phenotype (SASP) in osteosarcoma metastasis and in pulmonary fibrosis, and 3) an examination of the roles of the non-tumor tissue adjacent to osteosarcoma metastases. In addition, any identified druggable targets will be examined in preclinical (mouse) models to prioritize the best agents to carry forward into pet dog clinical trials, conducted through our extramural clinical trials consortium, the Comparative Oncology Trials Consortium (COTC).

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of Avinash Bhandoola at the National Cancer Institute. The laboratory studies the development of T cells, innate lymphocytes, and thymic epithelial cells. New cellular intermediates in the development of innate lymphocytes were recently described by Dr. Bhandoola’s lab, and we wish to evaluate the role of specific transcription factors in this process. Other work in the laboratory studies regulation of thymus growth, and is focused on identifying new types of thymic epithelial cells and transcription factors important for their function. The laboratory is adjacent to the laboratories of Andre Nussenzweig, Eros Lazzerini Denchi, and Sergio Ruiz, and the four laboratories together are an outstanding training and research environment.

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the laboratory of Dr. Yuichi Machida in the Developmental Therapeutics Branch (DTB), CCR, NCI-NIH to study DNA repair mechanisms and their effect on anti-cancer drugs. Dr. Machida’s team studies proteases involved in the repair of DNA-Protein Crosslink (DPC) damage using molecular and cellular biology techniques as well as mouse genetics. The successful candidate will investigate the proteolytic mechanism of DPC repair using X-ray crystallography and develop protease inhibitors as a sensitizer of anti-cancer drugs.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Fully funded postdoctoral fellow positions are available in Dr. Yousuke Takahama’s Thymus Biology Section in the Experimental Immunology Branch (EIB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) in Bethesda, MD. The laboratory focuses on the biology of the thymic microenvironments that contribute to the generation of functionally potent and self-tolerant T cells. The candidate will perform basic research on the development and function of diverse thymic epithelial cell subpopulations. Please visit our website for more information.

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28. Senior Investigator – RNA biology

Summary of Postdoctoral Fellowship:

The National Cancer Institute (NCI), Center for Cancer Research (CCR), RNA Biology Laboratory (RBL) is seeking an outstanding, internationally known scientist to lead an independent research group focused on any area of RNA biology. The successful candidate will be part of the newly established RBL on the Frederick, Maryland campus. The RBL, which is the equivalent of a small department at an academic institution, was formed in 2017 to enhance RNA research at the NCI. The successful candidate will be eligible to be appointed as an NIH tenured Senior Investigator, a position equivalent to a tenured Associate Professor or Professor at a university. The investigator will be able to take advantage of the stable resources provided by the Intramural Research Program to lead a world-class research program. The NCI is committed to building and supporting an exceptional RBL with state-of-the-art facilities and outstanding faculty. We are located on the NCI-Frederick campus, which houses a wide range of technological assets, including cryo-electron microscopy, a well-equipped biophysics core facility and high-quality core facilities dedicated to protein chemistry, mass spectrometry, imaging, microscopy, proteomics, genomics, genome modification, flow cytometry and bioinformatics/biostatistics.

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29. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Recent progress in cancer immunotherapy has emphasized how multifactorial and systemic immune responses must be to trigger tumor eradication. The need for quantitative and actionable models is being acutely felt to expand our fundamental understanding of the immune system, and to usher new immunotherapies. The Altan-Bonnet group is studying the interplay between innate and adaptive immune responses across the whole organism. We aim to identify key immunoregulatory events distinguishing tumor progression versus eradication. We rely on mass cytometry (so-called spectral cytometry) and quantitative modeling to systematically map out the homeostasis and dynamics of immune activation across multiple cell types. To do so, we study mouse models of cancer development, and are translating our mouse-derived understanding to the analysis of clinical samples. Our ultimate goal is to develop quantitative models of interactions between immune and cancer cells to tackle their complex interactions, and to predict how to tweak the immune responses best.

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30. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

One postdoctoral position is available in the Larion laboratory at the Neuro-Oncology Branch, CCR, NCI. My laboratory is focused on understanding the metabolic changes in brain tumors. In particular, we are interested in revealing the lipid alterations of isocitrate dehydrogenase (IDH1)-mutated gliomas and in exploiting these deregulations for therapeutic applications. We employ a combination of methods such as molecular biology, animal models, as well as in vitro and in vivo metabolomics using Raman Imaging Microscopy, and Mass Spectrometry (MS). The postdoctoral fellow will explore the link between lipid gene alterations in brain tumors and their biology. This position requires expertise in Western Blotting, mammalian cell culture and other common biomedical techniques used in cancer biology labs such as handling tissue samples, preparing tissue slides, staining, and extraction of proteins from brain tissue.

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is currently available in a research program focused on a variety of key aspects of HIV-1 assembly, release, and maturation. Of particular interest are the interplay between viral and host factors in HIV-1 replication and the mechanism by which the viral envelope glycoproteins are incorporated into virions. Recent studies have been aimed at defining the cellular pathways and host factors involved in envelope glycoprotein incorporation and identifying inhibitors of virus maturation. Mechanisms of HIV-1 drug resistance are also under investigation, and studies are underway to define the target and mechanism of action of novel HIV-1 maturation inhibitors and to identify host factors that restrict HIV-1 replication.

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32. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Signaling from Eph receptor tyrosine kinases and the ephrin transmembrane ligands affect morphogenesis during development and have been shown to play an instructive role in angiogenesis, as well as tumor cell invasion. Since we found a connection between the key Wnt signaling scaffold, Dishevelled, and ephrinB proteins, we have extended our analysis to examine how the intersection of Wnt/Planar Cell Polarity (PCP) and ephrinB signaling alters the mechanisms of signal transduction of these pathways. Moreover, we investigate how the output of these pathways lead to the creation of highly ordered intricate structures during development. Both Xenopus (Frog) and mammalian tissue culture systems are employed in projects that involve the functional and molecular characterization of the cellular and developmental effects mediated by the ephrinB and Wnt pathway proteins. A postdoctoral position is available in 2022 to study the role of ephrin and Wnt signaling pathways in cell movement and morphogenesis. A combination of molecular, cell biological, and biochemical techniques are applied in the amphibian developmental and mammalian culture systems. See recent publications: Sun et al., EMBO Rep. 2022; Lee et al., J. Cell Biol 2022; Yoon et al., Development 2021; Lee et al., J. Cell Biol. 2019; Yoon et al., Nature Comm. 2018).

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33. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Sphingolipid and Phospholipid Signaling Section, Jairaj K. Acharya, MBBS, Ph.D, Head, and the Cancer and Developmental Biology Laboratory, CCR, NCI, has an immediate opening for a postdoctoral position to study in vivo impact of sphingolipid metabolic enzymes in hematologic malignancies and organ function using a combination of genetic, molecular, biochemical and cell biological methodologies in mouse model systems. With nation-wide responsibility for improving the health and well-being of all American citizens, the U.S. Department of Health and Human Services oversees the biomedical research programs of the National Institutes of Health (NIH) and those of its 27 Institutes and Centers.

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34. Staff Scientist – Oncology, molecular biology, RNA biology

Summary of Postdoctoral Fellowship:

Our long-term working goal is to explore the molecular and cellular biology of thoracic cancers, with special focus on those affecting surface cavities like mesothelioma and thymic epithelial tumors, in order to develop strategies that can improve diagnosis and treatment paradigms. Other tumors of interest include lung carcinomas or metastatic tumors to the thorax, neuroendocrine tumors, esophageal cancer etc. The scope of our projects are translational by design. Currently, we have 2 portions of the lab, one pursuing discovery and the other focused on therapeutics development. Project I: design novel models of oncogenesis and perform comprehensive genomic and physiologic characterization that will facilitate developing novel, clinically relevant molecular biomarkers. Project II: investigate microRNA-mRNA interactions to inform on the pathogenic signaling pathways relevant to tumor initiation, invasion, metastasis, and resistance in malignant mesothelioma. With these projects, we have translational aims of novel therapeutic targets based on an understanding of the active cancer-specific mechanisms. Also, we are developing novel in vivo delivery platforms for nucleic-based agents that require pre-clinical testing in mouse tumor models. The culmination of these projects will be linked to clinical human testing in these thoracic cancers of interest.

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35. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral fellow position in immunology and cellular therapy is available in the Laboratory of Dr. Sung-Yun Pai, Chief of the Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute. Dr. Pai’s research focuses on the study of inborn errors of immunity, its treatment with allogeneic transplantation and gene therapy using viral vectors and the development of novel treatments for these disorders. The laboratory performs translational research using rare disease human samples, mouse models, molecular biology, and material from multi-institutional clinical trials.

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36. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the laboratory of Dr. Yuichi Machida in the Developmental Therapeutics Branch (DTB), CCR, NCI-NIH to study DNA repair and their roles as tumor suppressor mechanisms. Dr. Machida’s team studies proteases involved in the repair of DNA-Protein Crosslink (DPC) damage using molecular and cellular biology techniques as well as mouse genetics. The successful candidate will investigate the mechanisms underlying genomic instability and tumor-prone phenotypes caused by defective DPC repair.

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37. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in the laboratory of Jadranka Loncarek, Cancer Innovation Laboratory, CCR, NCI, NIH. The Loncarek lab studies the mechanisms of centrosome biogenesis and function using transformed and untransformed human cultured cells as experimental models. The goal of our research is to understand the fundamental principles of centrosome and centriole biology and how centrosome perturbations occur and contribute to human pathologies such as cancer. The projects currently available aim to understand: 1) the process of centriole/centrosome assembly and 2) cell-cycle perturbations that lead to centrosome reduplication. We are seeking highly motivated and collaborative candidates with a background in cell biology or biochemistry. The successful candidate will use a multiprong experimental approach combining biochemistry, genetics, proteomics, and a variety of imaging modalities (ranging from live-cell imaging, super resolution microscopy, expansion microscopy, and electron microscopy), to answer research questions.

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38. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral fellow position is available in the Thoracic Surgery Branch, CCR, NCI, NIH. Our broad goal is to explore the molecular and cellular biology of thoracic cancers, namely mesothelioma and/or, thymoma, non-small cell lung carcinoma, etc. Currently, we have projects that involve (1) investigating microRNA-mRNA interactions in malignant mesothelioma, (2) novel local therapeutic delivery system(s) able to carry diverse types of payloads including nucleic acid, immunotherapeutics, targeted small molecule agents, or antibodies, (3) on the pathogenic signaling pathways relevant to tumor initiation, invasion, metastasis, and resistance, (4) constructing next-generation models of normal cells/tissues that can be used to model tumor development and processes as well as several other translational-based endeavors (e.g., developing novel tumor diagnostics and prognostics, etc.). With these projects, we have aims of developing novel molecular biomarkers and therapeutic targets based on an understanding of the pathogenetic mechanisms active in these cancers. The culmination of these projects will be linked to clinical human protocols in these thoracic cancers of interest.

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39. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are recruiting a highly motivated postdoctoral researcher to study the impact of RNA post-transcriptional modifications on gene expression and cell identity. Our laboratory aims to understand, at the molecular level, how interactions between cellular environment and the RNA epigenome impact the RNA-centric regulatory networks that control cell identity, and how disruption of such pathways contribute to: 1) the establishment and proliferation of tumors; and 2) the development of resistance against therapeutic intervention. We employ a very broad range of state-of-the-art techniques including RNA-seq, proteomics and CRISPR genome editing.

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40. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the laboratory of Dr. Xin Wei Wang, Laboratory of Human Carcinogenesis, CCR, NCI, to study functional genomics of liver cancer.

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41. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is open in the laboratory of Dr. Deborah Citrin, Radiation Oncology Branch, CCR, NCI, NIH in Bethesda, Maryland. Projects in the Citrin lab have focused on modulation of tumor and normal tissue response to DNA damaging agents, such as radiation. This work has included the identification of agents targeting signal transduction pathways and metabolism that can enhance the sensitivity of solid tumors to DNA damage. Our laboratory identified that inhibition of selected molecules, such as MEK1/2 and Sp1are capable of enhancing tumor response to DNA damaging agents (Clinical Cancer Research, 15(9): 3050; Clinical Cancer Research, 17(15):5038; International Journal of Radiation Oncology Biology Physics, 100(2): 344-52). The laboratory has a history of studying resistance factors to DNA damage and has further evaluated metabolic imaging and metabolic inhibitors in prostate cancers (Clinical Cancer Research, 24(13): 3137). The laboratory has conducted these studies in diverse solid tumor histologies with the goal of clinical translation in Dr. Citrin’s active clinical trial program.

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42. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Genetics of Cancer Susceptibility Section in the Mouse Cancer Genetics Program (MCGP), CCR, NCI is seeking highly motivated postdoctoral researchers to identify novel genetic interactors of BRCA2 and to evaluate the functional significance of BRCA2 genetic variants using CRISPR-based technologies in mouse embryonic stem cells and in mouse models. Detailed information on the lab’s current research can be found on the Sharan Lab’s website. The MCGP offers challenging, stimulating and collaborative research and training opportunities to postdoctoral fellows. The position is available immediately.

Last Application Date: Open Until Filled

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43. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We offer one fully funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH). NIH is the largest biomedical research agency in the world, fosters world-renowned researchers and provides access to state-of-the art innovative technologies and scientific resources. Our laboratory uses human and mouse embryonic stem cells, as well as mouse embryos to understand the molecular mechanisms underlying cell fate decisions. The applicant will be involved in a very exciting project investigating the relation between cell plasticity/totipotency and chromatin architecture.

Last Application Date: Open Until Filled

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44. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Multiple post-doctoral positions are available with Dr. Lisa Boxer in the Laboratory of Genome Integrity to study chromatin regulation of neuronal development. The Boxer lab uses molecular and genomic approaches to study how mutations in chromatin regulators disrupt neuronal gene expression and lead to neurodevelopmental disorders and cancer. Dr. Boxer is part of a highly integrated, interactive and collaborative research environment that provides an ideal training and mentoring setting for young scientists. Her research group will be adjacent to the laboratories of Branch Chief Andre Nussenzweig, Senior Investigators Eros Lazzerini Denchi and Avinash Bhandoola, and Stadtman Investigator Sergio Ruiz Macias.

Last Application Date: Open Until Filled

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45. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

CAR-T cell-based immunotherapy has shown promising efficacy in some hematologic tumors. However, this approach has shown limitations in major solid tumors, including liver cancer and pancreatic cancer. Dr. Mitchell Ho’s lab at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans (GPC3 and GPC2), mesothelin and B7-H3 as tumor-associated targets. To develop next-generation cell-based therapies, we are engineering potent CAR constructs for T or natural killer (NK) cell-based therapies via antibody protein engineering and computational design. Some of our research has led to clinical trials for treating cancer patients.

Last Application Date: Open Until Filled

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46. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral researcher position in the fields of cell biology, translational cancer research, and/or molecular pathology is available in the laboratory of Adam Sowalsky (Prostate Cancer Genetics Section) at the CCR, NCI, NIH. The Sowalsky Lab is a part of the Laboratory of Genitourinary Cancer Pathogenesis, an interdisciplinary group entirely focused on prostate cancer. The major goals of the Sowalsky Lab are to identify molecular characteristics of patients with prostate cancer based on their responses to therapy, validate those features as biomarkers, and test them in clinical trials at the NIH Clinical Center. Together with our collaborators in the urology and oncology branches, we are generating unique and very large, high-volume datasets with extensive clinical annotation, with the goal of identifying opportunities for integrating precision medicine into clinical practice.

Last Application Date: Open Until Filled

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47. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position in cellular and molecular immunology is available in the lab of Dr. Hyun Park, Experimental Immunology Branch, CCR, NCI, on the main campus of the NIH in Bethesda, Maryland. The laboratory’s research interest focuses on understanding the role of cytokine receptor expression and signaling in T cells. Specifically, we seek to understand the transcriptional and post-transcriptional mechanisms of cytokine receptor expression and downstream signaling in T cells.

Last Application Date: Open Until Filled

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48. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Yoo laboratory, in the Chemical Biology Laboratory, CCR, NCI, has an opening for a postdoctoral fellow. The goal of our research project is to study functional proteases that play important roles as instigators and regulators of immune responses and understand how they shape the tumor microenvironment and dictate the fate of tumor cells. Our research focuses on the development and application of chemical strategies that allow kinetic and dynamic measurement of the network of protease activities. We use our expertise in synthetic chemistry to synthesize small molecules and peptidomimetics to probe and inhibit the activity of proteases and utilize biochemistry, structure biology, molecular biology, and chemical proteomics to characterize the protease-ligand interactions.

Last Application Date: Open Until Filled

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49. Staff Scientist – Behavioral science, psychosocial research, pediatric

Summary of Postdoctoral Fellowship:

The Psychosocial Support and Research Program in the Behavioral Health Core of the Pediatric Oncology Branch, (POB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) invites applicants for a full-time staff scientist position, preferably mid-career. This position utilizes a scientist-practitioner model, bridging clinical practice with a robust psychosocial research program. The Psychosocial Support and Research Program is dedicated to providing behavioral health care to children, teens, and young adults with cancer and other chronic medical conditions who are enrolled on natural history studies, clinical treatment trials, and psychosocial interventions at the NIH Clinical Center. We work collaboratively with physicians, psychologists, social workers, recreation therapists, palliative care specialists and allied professionals to provide comprehensive care in the form of quality clinical services to children and their family members enrolled on CCR clinical trials to help enhance coping and adaptation.

Last Application Date: Open Until Filled

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50. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair proteins in a variety of cancers that include leukemias and breast cancers, using mouse models. The position will emphasize efforts to understand gene regulation, chromatin, regulatory and structural variation and its relation to cancer. The position will involve analysis of applications involving high-throughput DNA sequencing methods for a variety of assays, including RNA-seq, exon sequencing, ATAC-seq, DNase-seq, ChIP-seq, END-seq and newer, cutting-edge methodologies that are in development.

Last Application Date: Open Until Filled

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51. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

One post-doctoral position is immediately available with Dr. Andre Nussenzweig in the Laboratory of Genome Integrity, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) to study the mechanisms involved in DNA double-strand break repair, with a focus on understanding the influence of chromatin structure on the maintenance of genome integrity and their roles in a variety of cancers using cutting-edge cellular, molecular, and genomic tools.

Last Application Date: Open Until Filled

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