15 Postdoctoral Jobs at Institut Pasteur, Paris, France

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If you’re a PhD degree holder and seeking postdoctoral fellowships, Institut Pasteur, Paris, France has several online applications open. Explore the opportunities across diverse research areas and submit your application soon.

1. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Trypanosoma brucei is an extracellular parasite responsible for sleeping sickness in Africa and transmitted by a blood-feeding insect vector, the tsetse fly. In its mammalian host, the rapidly dividing slender forms predominate in the blood and tissues. At the peak of parasitaemia, slender forms differentiate into growth-arrested stumpy forms (ST) to protect the host by preventing high parasitaemia. Slender to stumpy differentiation relies on a quorum sensing mechanism triggered by the accumulation of di- and tripeptides produced by oligopeptidases excreted by the parasites. The current model of T. brucei transmission from mammals to the insect vector emphasises the key role of the quorum sensing-derived stumpy forms (ST-QS) produced in the blood. 

Application Deadline: Open Until Filled

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2. Postdoctoral Job

Summary of Postdoctoral Fellowship:

A postdoctoral position is available to study dynamic processes in early development of insects and mammals. Successful candidates will join a collaborative and interdisciplinary venture in the newly formed unit Physics of Biological Function of biophysicist Thomas Gregor.

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3. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Our laboratory is part of the Neuroscience Department of the Institut Pasteur and gathers psychiatrists, neuroscientists and geneticists to understand the causes of autism. We previously identified the first mutations in the NLGN-NRXN-SHANK pathway, which has a key role in synapse formation within the brain. Our results highlight the genetic heterogeneity of autism, but also point at common biological mechanisms that could constitute relevant targets for new treatments. We are leading the genetic work package of AIMS-2-TRIALS, the largest European project on autism research. The project is focused on deep-phenotyping of individuals with autism and controls including brain imaging (EEG and MRI) and a battery of cognitive tests. 

Application Deadline: Open Until Filled

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4. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Humoral immunity is essential to host protection against human infections, and relies on the phenomenal diversity of antibody molecules sensing and inactivating pathogens. Our understanding of pathogen-specific B-cell responses has increased substantially in recent years with the advent of modern technologies permitting the fine characterization of single B-cell-derived human monoclonal antibodies. Our lab studies at a serological, cellular and molecular level, principally by generating and characterizing virus-specific antibodies, the human humoral responses to viruses i.e., HIV-1, Hepatitis E and B, as well as emerging viruses such as SARS-CoV-2. These recombinant antibodies represent unique “fingerprints” for each B-cell clone, and when characterized at both molecular and functional levels, provide knowledge on the humoral response to the pathogen to be utilized to design novel immunogens and vaccine strategies. 

Application Deadline: Open Until Filled

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5. Postdoctoral Job

Summary of Postdoctoral Fellowship:

The goal is to analyze the immune response to HBV during and after treatment with a combination of antiviral and immune modulating therapies using a humanized mouse model. Innate and adaptive immunity will be characterized to determine whether efficient immune responses are restored, leading to seroconversion and a functional cure off treatment. We aim to decipher the immune response leading to viral persistence versus viral control and uncover predictive biomarkers of each state.

Application Deadline: Open Until Filled

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6. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Our laboratory is part of the Neuroscience Department of the Institut Pasteur and gathers psychiatrists, neuroscientists and geneticists to understand the causes of autism. We previously identified the first mutations in the NLGN-NRXN-SHANK pathway, which has a key role in synapse formation within the brain. Our results highlight the genetic heterogeneity of autism, but also point at common biological mechanisms that could constitute relevant targets for new treatments. We are leading the genetic work package of AIMS-2-TRIALS, the largest European project on autism research. 

Application Deadline: Open Until Filled

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7. Postdoctoral Job

Summary of Postdoctoral Fellowship:

We are looking for a computational biologist/bioinformatician at the postdoc/research assistant level to join the ERC Synergy project DecoLeishRN (https://cordis.europa.eu/project/id/101071613). The successful candidate will join and collaborate with a vibrant, international team that applies experimental evolution to study mechanisms of fitness gain in the eukaryotic pathogen Leishmania. The candidate will apply and develop computational tools for the analysis of large data sets generated by short-read, long-read, and single cell DNAseq/RNAseq analyses of cells evolving in vitro in culture and in vivo in infected animals. The major aim of his/her project is to understand how Leishmania can harness its intrinsic genome instability for the evolution of beneficial phenotypes.

Application Deadline: Open Until Filled

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8. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Our group is interested by the fine tuning of cell death in epithelial context using Drosophila as a model system (https://research.pasteur.fr/en/team/cell-death-and-epithelial-homeostasis/). We use a wide range of live imaging technics, live sensors, optogenetic, image analysis (including machine learning assisted cellular event recognition) and modeling to dissect quantitatively the feedback fine tuning cell death. Our pojects are currently focusing on studying the impact of mechanical stress on apoptosis regulation, the role of apoptosis in the fine tuning of tissue growth and morphogenesis, the coupling between proliferation and death, the coordination of cell extrusion by caspases and the fine tuning of epithelial cell death decision downstream of caspase activation.

Application Deadline: Open Until Filled

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9. Postdoctoral Job

Summary of Postdoctoral Fellowship:

Our laboratory has one position available for postdoctoral fellow in the area of inflammation and regenerative disease research. We are interested in mechanisms of immunoregulation and tissue adaptation to external challenges, with an emphasis on tissue long lived cells such as stromal cells, and their crosstalk with immune cells, stem cells and the vasculature. We perform mostly in vivo studies, combining lineage tracing and depletion models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using these approaches, we previously identified an essential role for specific subsets of stromal cells in tissue repair and cancer immunity (Dulauroy et al., Nature Medicine 2012; Stzepourginski et al., PNAS 2017; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). 

Application Deadline: Open Until Filled

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10. Postdoctoral Job

Summary of Postdoctoral Fellowship:

One of the main obstacles to overcome is the formalization of a methodology allowing the transfer of knowledge and biological results to the creation of DNN and SNN neural networks. You will carry out this formalization work in close collaboration with the teams of the Pasteur Institute. You will then apply this methodology to the design and implementation of bio-inspired DNN and SNN neural networks and demonstrate the relevance of the approach through in-depth tests of their performance (computational and energetic). 

Application Deadline: Open Until Filled

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11. Postdoctoral Job

Summary of Postdoctoral Fellowship:

We are looking for a computational biologist interested in pathogen evolution to join us to work on exciting projects combining molecular epidemiology and functional studies of arboviral infections. The aim of the current project is to study dynamics of arbovirus emergence or endemic circulation, and the underlying mechanisms, at the scale of individual outbreaks through the integrated analysis of genomic, temporal and functional data.

Application Deadline: Open Until Filled

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12. Postdoctoral Job

Summary of Postdoctoral Fellowship:

The project aims at identifying and characterizing the components involved in elongation and division in archaea with a PG cell wall. The candidate will use our two experimental models: Methanobrevibacter smithii, an ovococcoid and the main species of methanogens from the human gut, and Methanothermobacter thermautotrophicus, a genetically tractable rod-shaped environmental relative. One axis of the project focuses on the candidates already identified and will involve the construction of mutants and their phenotypic characterization (phase contrast, fluorescence microscopy, protein-protein interaction). The second axis will aim at discovering new components using diverse approaches (transposon mutagenesis screens, protein pulldowns, bacterial two hybrid).

Application Deadline: Open Until Filled

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13. Postdoctoral Job

Summary of Postdoctoral Fellowship:

The laboratory is interested in developing new therapeutic strategies inspired by the mechanisms associated with control of HIV infection in rare individuals who are able to maintain undetectable viral loads for very long periods of time in the absence of antiretroviral treatment. The research program will be focused on recent results from the laboratory showing that cell metabolism is a critical determinant of HIV infection on CD4+ T cells and of the efficacy of HIV-specific CD8+ T cells. The program includes the analyses of cells from metabolic interventions in preclinical models. Experimental approaches will cover cellular biology, immunology and virology.

Application Deadline: Open Until Filled

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14. Postdoctoral Job

Summary of Postdoctoral Fellowship:

The main project concerns experimental models of virus evolution and will be developed in close collaboration with other teams at Institut Pasteur. We are looking for a highly motivated post-doctoral scientist with strong experience in either molecular and evolutionary biology, mutational analysis, or reverse genetics, and work in BSL-3 environment. Knowledge of next generation sequencing techniques would be desirable but not essential.

Application Deadline: Open Until Filled

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15. Postdoctoral Job

Summary of Postdoctoral Fellowship:

The Machine Learning for Integrative Genomics team at Institut Pasteur, headed by Laura Cantini, works at the interface of machine learning and biology, developing innovative machine learning methods for single-cell data analysis (tools developed by the team: https://github.com/cantinilab). Single-cell high-throughput sequencing, extracting huge amounts molecular data from a cell, is creating exciting opportunities for machine learning to address outstanding biological questions. The postdoc to be recruited will be working on the development of machine learning methods for single-cell data and will require interactions with collaborators of the team.

Application Deadline: Open Until Filled

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