41 Postdoctoral Fellowships at Karolinska Institute, Sweden

Are you holding PhD degree and looking for Postdoctoral Fellowships? Karolinska Institute, Sweden inviting application for multiple Postdoctoral Fellowships. Karolinska Institute is one of the largest university in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.

Karolinska Institute has huge a campus in Sweden and widely known as for its contribution in top notch education and research. The contribution of Karolinska Institute is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..

1. Postdoctoral studies in Cancer Genetics (scholarship) – for Ukranian researcher

Summary of Postdoctoral Fellowship:

We investigate genetic disorders on a molecular level in a translational research setting in order to understand disease mechanisms, apply new knowledge in genetic diagnostics, improve prognosis assessment and develop new treatment strategies. Our research group consists of four teams and our main interests are hematological malignancies, with a particular focus on chronic lymphocytic leukemia, lymphoma and pediatric acute lymphoblastic leukemia, metabolic bone disorders, and cancer genetics.

Last Application Date: 30.Sep.2022

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2. Postdoctoral Position in Computational Biology of Parkinson’s Disease at the single-cell level

Summary of Postdoctoral Fellowship:

We are looking for a creative computational biologist seeking to study neurodegeneration in Parkinson’s disease at the single cell level. The project involves analysis of single cell RNA-seq, multiome and in situ sequencing data generated from different brain regions of control and Parkinson’s disease patients. You will use your experience in performing bioinformatics analyses of sequencing data, to analyze and integrate transcriptomics and epigenomics data. You will have your own project, and you will be encouraged to address challenging questions, think independently and develop high impact research. You will interact and collaborate with other lab members working in the dry and the wet lab. The successful candidate will also have the opportunity to supervise students and to achieve personal development.

Last Application Date: 02.Sep.2022

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3. Postdoctoral researchers in Cell transplantation for Parkinson’s disease

Summary of Postdoctoral Fellowship:

We look for postdoctoral researchers interested in stem cell biology and in developing cell replacement strategies for Parkinson’s disease. The successful candidate will transplant neural progenitors derived from pluripotent stem cells in transgenic mouse models of Parkinson’s disease (PD) or in 6-hydroxydopamine models of PD. Applicants will work on one of the two following projects: 1) Identification of the optimal cell preparation and cell composition to achieve precise and effective cell replacement with the minimal number of cells and cell types. Focus will be placed on appropriate integration of cells in the host brain at an anatomical level (establishment of afferent and efferent projections); at a functional level (electrophysiological, neurochemical and behavioral analysis); and at a molecular level, by using as single cell methodologies.

Last Application Date: 02.Sep.2022

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4. Applications are invited for a postdoctoral position in Onur Dagliyan’s Group

Summary of Postdoctoral Fellowship:

Neuronal activity dependent molecular signaling processes are central for brain development and plasticity. These molecular events form the mechanistic basis of complex neural computation, learning and memory. Experience-driven activation of proteins often at the post-translational level mediate the rapid events including synaptic modifications, metabolic adaptations, and the transfer of the cytosolic protein signals into the nucleus to influence gene expression. The Dagliyan laboratory focuses on specific molecular events in neurons happening at these different time scales, starting from the immediate modifications at the synapse, such as actin-modifying protein signaling, to longer time scale molecular events such as protein modifications that mediate transcription initiation, elongation, and RNA splicing, which are key processes for the behaviorally induced plasticity of neuronal circuits.

Last Application Date: 01.Sep.2022

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5. Postdoctoral Researcher in Materials Science

Summary of Postdoctoral Fellowship:

Ming Wai Lau Centre for Reparative Medicine (MWLC) aims to contribute to the improvement of human health by conducting cutting-edge research in reparative medicine and related subjects, by creating a new platform for synergies between academia and innovation in Sweden and Hong Kong as well as China, and fostering future leaders in both academia and industry. Description of Research Group and Position The current research of Assistant Professor Sijie Chen aims at developing novel fluorescence-based tools and technology for biological research. One Postdoctoral Researcher position in Materials Science is available.

Last Application Date: 31.Aug.2022

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6. Postdoctoral Researcher in metabolomics of asthma

Summary of Postdoctoral Fellowship:

We have an opening for an individual wishing to join a multidisciplinary project aimed to develop quantitative methods for molecular phenotyping of asthma. Based upon our previous metabolomics studies on asthma, the aim of this project is to develop targeted quantitative methods for personalized medicine applications in asthma. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of small polar compounds and lipids. The methodology will be formatted for high-throughput application in 96-well plate format using automated sample preparation techniques. Developed methods will be employed in multiple large-scale clinical studies, with a focus on interventional studies and precision pharmacotherapy with novel biologics (e.g., mepolizumab, omalizumab). This project will be performed in collaboration with researchers at the Harvard Medical School.

Last Application Date: 31.Aug.2022

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7. Postdoctoral Researcher in lipid bioanalytical chemistry of respiratory disease

Summary of Postdoctoral Fellowship:

We have an opening for an individual wishing to join a multidisciplinary project aimed to understand the role of lipid mediators in lung disease. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of lipid mediators including eicosanoids (e.g., prostaglandins, leukotrienes), novel octadecanoids and structural lipids. Analyses will involve further development of novel chromatography approaches including chiral and UPC2 methods for applications in large scale clinical studies as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of lung disease. Functional studies will be performed in multiple cell types, in ex vivo lung tissue as well as in animal models to generate a biochemical map of both pro-inflammatory and pro-resolving lipid mediators. This project will be performed in collaboration with researchers at the University of California San Francisco (UCSF).

Last Application Date: 31.Aug.2022

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8. Postdoctoral position in the area of single-cell genomics

Summary of Postdoctoral Fellowship:

Ana Mendanha Falcão is a research group leader focusing on the role of the choroid plexus in diseases such as multiple sclerosis. Her team aims to investigate the choroid plexus as a source of biologically active molecules to the central nervous system, in order to influence disease dynamics. The choroid plexus is studied as an alternative target for disease therapies since it can be modulated by peripheral blood and it can substantially alter the brain composition both in terms of biologically active molecules and immune cell content. The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. Our research group has performed single nuclei/cell RNA-Seq and ATAC-seq and identified several cell states within the oligodendrocyte lineage in development and disease (Nature Medicine 2018, Nature 2019, Neuron 2022), including an immune state that might be relevant for the etiology and/or progression of MS.

Last Application Date: 31.Aug.2022

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9. Two Postdoctoral Researcher/ The Strategic Research Programme for Diabetes

Summary of Postdoctoral Fellowship:

We are interested in understanding how skeletal muscle insulin sensitivity is altered, both in response to pathology such as type diabetes, and as a response to physical exercise. This fellowship programme is focused on the role of miRNAs in this regard, in particular miRNAs in small extracellular vesicles (also called exosomes. We have previously identified several miRNA which are dysregulated in skeletal muscle in subjects with type 2 diabetes, and which contribute to changes in metabolism and insulin signalling, including let7 (Jiang et al., 2013), miR-29 (Massart et al., 2017) and mIR20b (Katayama et al., 2018). Since miRNAs are able to target multiple genes simultaneously, miRNAs provide a potential mechanism for efficiently modulating a whole pathway to change or alter the functional properties in specific target tissues.

Last Application Date: 31.Aug.2022

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10. Postdoctoral researcher in “Single cell multiomics of Parkinson’s disease”

Summary of Postdoctoral Fellowship:

We look for a postdoctoral fellow interested in working on a project aiming at understanding the molecular mechanisms behind neurodegeneration and the formation of neuromelanin and a-synuclein aggregates in Parkinson’s disease (PD). The project involves the use of human postmortem samples from PD patients as well as transgenic mouse models of PD. The goal of the project is to identify the molecular phenotypes of cell types from different brain regions by defining changes in gene expression, gene regulation and transcriptional networks at the single cell level, using a multiomics approach, in situ transcriptomics methods and computational tools. This project is supported by a Collaborative Research Network (CRN) program of the Aligning Science Across Parkinson’s (ASAP), an initiative implemented through The Michael J. Fox Foundation, which aims at understanding the cause and molecular mechanisms underlying PD.

Last Application Date: 15.Aug.2022

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11. Postdoctoral Researcher in Rare Skeletal Diseases

Summary of Postdoctoral Fellowship:

We are interested in candidates with prior experience on a variety of genetic methods, e.g., exome and whole-genome sequencing data analysis, Sanger sequencing, and transcriptome analysis as well as familiarity with high performance computing environment, Linux, phyton, R scripting or other programming language. Other advantageous skills may include data analysis of short- and long-read sequencing (e.g., Oxford Nanopore, PacBio) as well as optical mapping (e.g., Bionano), and experience with whole genome methylation analysis. Once a disease-causing gene variant is found, the researcher will work together with other experts in the team to establish in vitro cell models to validate the findings.

Last Application Date: 15.Aug.2022

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12. ONE Postdoctoral Researcher in chemical and genetic screens

Summary of Postdoctoral Fellowship:

We are looking for a postdoctoral scientist to join our team with a Ph.D. in Cell Biology, Molecular Biology, Biochemistry or other relevant fields. A background in senescence, cell cycle or DNA damage signaling would be a merit. We are specifically looking for a highly motivated scientist, who aims to complement his/her skills with experience in large chemical and genetic screens and has the capacity to independently develop a scientific research project that relies mostly on cell and molecular biology technologies. In addition, it is expected that the candidate will help in the training of junior group members. Other valuable skills such as writing or presenting capacities or social skills will also be appreciated.

Last Application Date: 02.Aug.2022

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13. Postdoctoral researcher in Developmental/ Computational Neurobiology (scholarship)

Summary of Postdoctoral Fellowship:

The Marklund lab addresses principal questions in ENS biology with a focus on neural cell diversity. The team has recently identified molecularly distinct neuronal cell classes in the ENS as well as a new conceptual model for they emerge during the development (Morarach et al., 2021). These discoveries form the basis for an ERC-funded project, requiring an expansion of the team. The new project seeks to uncover molecular programs controlling cell fate decisions during embryonic and adult enteric neurogenesis and thereafter apply these insights to engineer specific neuron types within the adult gut wall. A wide range of transcriptomic, epigenetic, cellular, and imaging methodologies will be utilized to meet these aims. By resolving mechanisms of ENS development, the lab hopes to pave the way for a better understanding, characterization and treatment of prevalent gut disorders.

Last Application Date: 01.Aug.2022

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14. Postdoctoral Researcher in Enteric Neurobiology (scholarship)

Summary of Postdoctoral Fellowship:

The Marklund lab addresses principal questions in ENS biology with a focus on neural cell diversity. The team has recently identified molecularly distinct neuronal cell classes in the ENS as well as a new conceptual model for they emerge during the development (Morarach et al., 2021). These discoveries form the basis for an ERC-funded project, requiring an expansion of the team. The new project seeks to uncover molecular programs controlling cell fate decisions during embryonic and adult enteric neurogenesis and thereafter apply these insights to engineer specific neuron types within the adult gut wall. A wide range of transcriptomic, epigenetic, cellular, and imaging methodologies will be utilized to meet these aims. By resolving mechanisms of ENS development, the lab hopes to pave the way for a better understanding, characterization and treatment of prevalent gut disorders.

Last Application Date: 01.Aug.2022

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15. Postdoctoral researcher of mRNA translation in cancer

Summary of Postdoctoral Fellowship:

The Larsson lab focuses on understanding the role of mRNA translation in several cancer types and in both cancer and stromal cells. The focus is on achieving transcriptome-wide and detailed molecular understanding of how mRNA translation is dysregulated in cancer. The lab has expertise in development of state-of-the-art methods for wet-lab based studies of mRNA translation as well as development of computational tools to analyse the generated data. Although the focus for this project will be to use advanced molecular biology approaches to study mRNA translation in cancer, there will also be opportunities to learn analysis of large-scale data sets.

Last Application Date: 01.Aug.2022

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16. Postdoctoral Researcher in Computational Biology

Summary of Postdoctoral Fellowship:

We are recruiting a highly motivated and independent postdoc candidate with experience in next-generation sequencing data analysis, computational genomics, medical statistics, computational biology and/or imaging analysis. The project combines single-cell, multi-omics data with large scale human genetics to investigate the cellular origin of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD). The postdoc candidate will work closely with researchers in the team as well as with our collaborators and be responsible for data analysis, visualization, and development of new computational methods for processing and analysis of large-scale omics data. We welcome applications from candidates with pure computational background and those combining experimental and theoretical approaches.

Last Application Date: 31.Jul.2022

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17. Postdoctoral researcher in personalized medicine of infectious diseases

Summary of Postdoctoral Fellowship:

The ideal candidate should hold a Doctoral (or be near completion) degree in medicine, epidemiology, statistics, biostatistics, mathematics, computer science, health data sciences or a related field. An advantage is having worked with large amounts of clinical data or registers, and knowledge of programs such as R, STATA, SAS or Python. You should have experience of independent work, good communication and teamwork skills. A requirement is good knowledge of English, knowledge of Swedish is beneficial. Knowledge of statistics, machine learning techniques, database management, an understanding of clinical work, or infectious diseases is an advantage.

Last Application Date: 31.Jul.2022

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18. Postdoctoral Researcher in Bioinfomatics

Summary of Postdoctoral Fellowship:

The WHO research group in the department of Women’s and Children’s health is headed by Professor Kristina Gemzell Danielsson. The group’s work on translational medicine in the field of women’s reproductive health covers a wide spectrum of clinical, experimental and global reproductive health. One of the research field the group has worked extensively is the development and clinical application of progesterone receptor modulator in its clinical application. The team on experimental research in the laboratory is led by Associate Professor Lalit Kumar and has a focus on infertility, endometrial function, embryo implantation, endometriosis and prevention of breast cancer.

Last Application Date: 31.Jul.2022

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19. Postdoctor in Immunology

Summary of Postdoctoral Fellowship:

The project aims to study basic scientific questions regarding the regulation and function of B cell responses to relevant viral antigens, with the goal to gain insights in how to design future vaccines that induce optimal protection against specific viral infections. The team has established genetically modified mouse models and immunogens that will be used to evaluate these questions. In addition to taking the lead and advancing the specific research project(s), it is expected that the candidate contributes to common laboratory duties and participates in the supervision of research students.

Last Application Date: 31.Jul.2022

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20. Postdoctoral Researcher in Molecular and Cell Biology

Summary of Postdoctoral Fellowship:

Dr. Linxian Li’s group has long interest in developing novel therapeutics for clinical applications. Committed to translating new technology for medical use, the Li group focuses on using chemical synthesis, biological tools, and artificial intelligence to develop mRNA therapeutics. We are seeking a highly motivated postdoctoral researcher for research initiatives in Molecular and Cell Biology.

Last Application Date: 27.Jul.2022

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21. Postdoctoral Researcher in Computational Eicosanoid Research (scholarship)

Summary of Postdoctoral Fellowship:

We are looking for a highly motivated postdoctoral researcher in structural bioinformatics. The candidate is expected to participate in collaborative efforts to simulate leukotriene pathway enzymes with coarse-grained and atomistic simulation methods, in order to generate and test predictions in the lab. Advanced knowledge in structural bioinformatics and proven experience with molecular simulation tools (GROMACS, CHARMM, etc), multiscale and coarse-grained approaches is a prerequisite. The applicant must be well acquainted with programming & scripting languages common in the biomolecular simulation field (bash, python, etc). Previous experience with simulations of membrane proteins, knowledge of complimentary structural analysis techniques (Network Analysis, PCA, etc) and additional molecular modelling methods (docking, virtual screening, etc) will be highly valued.

Last Application Date: 27.Jul.2022

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22. Postdoctoral Researcher in RNA Biology

Summary of Postdoctoral Fellowship:

Ming Wai Lau Centre for Reparative Medicine (MWLC) aims to contribute to the improvement of human health by conducting cutting-edge research in reparative medicine and related subjects, by creating a new platform for synergies between academia and innovation in Sweden and Hong Kong as well as China, and fostering future leaders in both academia and industry.

Last Application Date: 27.Jul.2022

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23. Postdoctoral Researcher in Psychiatric Genetic Epidemiology

Summary of Postdoctoral Fellowship:

Dr. Bergen’s group conducts research investigating the genetic and environmental risk factors for psychiatric disorders, specifically, schizophrenia, bipolar disorder, eating disorders, and depression. Projects within this research area will be possible upon agreement, making use of the exceptional data from the Swedish National Registers and several genetically informed collections across a range of psychiatric disorders collected within Sweden. The open position is for a postdoctoral researcher for at least one year, and the position must start in September 2022 or earlier.

Last Application Date: 25.Jul.2022

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24. Postdoctoral studies in mitochondrial biology

Summary of Postdoctoral Fellowship:

We are looking for a highly motivated postdoctoral researcher interested in mitochondrial biology. Our research aims at identifying the molecular consequences of metabolic derangements, by understanding how mitochondria function within the metabolic system. For this, we use model systems, ranging from patient-derived samples, reprogrammed neuroepithelial stems cells to genetically modified animal models. We are specifically interested in the regulation of mitochondrial gene expression and post-transcriptional and post-translational modifications. The laboratory offers an outstanding research environment for basic and translational research with a close association to the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital.

Last Application Date: 20.Jul.2022

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25. Postdoctoral studies in Immunology to HERM / NEO (scholarship)

Summary of Postdoctoral Fellowship:

Professor Petter Höglund leads a translational immunology group with a focus on natural killer (NK) cells, platelets and neutrophils. See https://ki.se/en/medh/petter-hoglund-group for more information. The group is looking for a motivated, well-organized postdoctoral scientist to study the mechanisms underlying interactions between platelets and neutrophils with immune effector cells such as monocytes, macrophages and NK cells. There will be an initial focus on developing novel platforms for functional characterization of these interactions. The main responsibility will be to develop and conduct independent research projects at the postdoctoral level within the line of ongoing research in the group. The candidate is expected to provide expertise and constructive collaborative efforts into ongoing projects, including providing supervision of project students. Laboratory work in the group includes all aspects of an immunology lab, such as molecular biology, cell culture, flow cytometry, confocal and super-resolution imaging.

Last Application Date: 20.Jul.2022

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26. Postdoctoral position in viral immunology

Summary of Postdoctoral Fellowship:

The Buggert group conducts innovative studies of cell-mediated immunity in health, cancer, and viral disease. These studies are translational and involve the usage of cutting-edge bulk- and single-cell technologies, including high-parameter flow cytometry, gene-editing, RNA-seq, ATAC-seq, TCR-seq, and proteomics analysis to dissect the heterogeneity and function of memory T cell immunity. Through these platforms, we study different aspects of human memory T cell biology, with an overall aim to i) study the heterogeneity of circulating and resident memory T cells in human organ donors, ii) identify alternative functions of memory T cells in human tissues, and iii) understand how memory T cells maintain control of tumors and viral infections, such as SARS-CoV-2.

Last Application Date: 19.Jul.2022

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27. 1-4 postdoctoral scholarships in pharmacoepidemiology and causal inference

Summary of Postdoctoral Fellowship:

We seek dedicated and creative postdoctoral researchers to join our team. You will be involved in studies exploring the conditions of use (adherence, compliance, off and on-label use) and the effect (effectiveness, safety) of a number of licensed drugs and devices in ‘real world’ (routine practice) conditions. You will study unique data sources, including several Swedish Quality Registers and the Stockholm CREAtinine Measurements (SCREAM) project, a longitudinal administrative healthcare utilization cohort of >3 million residents of Stockholm with complete information on undertaken laboratory measurements. We employ both classic and advanced statistical methods, within the target trial emulation framework and with particular emphasis on causal inference statistics.

Last Application Date: 15.Aug.2022

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28. Postdoctoral researchers in “Astrocyte-to-neuron conversion for cell replacement in Parkinson’s disease”

Summary of Postdoctoral Fellowship:

We look for two postdoctoral fellows interested in developing precision cell replacement strategies for Parkinson’s disease based on cell engineering. Our laboratory has previously provided proof of concept that the conversion of astrocytes into midbrain dopamine neurons in vivo can rescue motor deficits in a mouse model of PD (Rivetti di val Cervo, 2017, Nature Biotechnology). We now aim at further developing these technologies, at improving the functionality of the converted DA neurons and at understanding the reprogramming process in grater detail by using, amongst others, single cell RNA-sequencing methodologies and computational tools to ascertain the quality of the DA neurons (La Manno et al., 2016, Cell; Nishimura et al., 2022, in preparation). Different aspects of the process of converting disease-associated astrocytes into induced midbrain dopaminergic neurons of the substantia nigra subtype, will be examined.

Last Application Date: 15.Aug.2022

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29. Postdoctoral Researcher in experimental psychology

Summary of Postdoctoral Fellowship:

You will be working at the National Centre for Suicide Research and Prevention (NASP) as part of an international team that is focused on research in the field of mental health and suicide prevention. As a postdoc you will design the protocols of the studies required by these projects, supervise their implementation, analyse quantitative data and lead the preparation of manuscripts reporting the findings. You will also offer scientific support and collaborate in work related to these projects such as participation and presentations in the technical project meetings, writing reports on the progress of the ongoing projects to the research Consortium, as well as assisting in project and financial management.

Last Application Date: 14.Aug.2022

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30. Postdoc in epidemiology using ensemble methods and big data

Summary of Postdoctoral Fellowship:

Common mental disorders (CMD) are the leading causes of long-term sickness absence. You will explore the relation between shift work (especially night work), long working hours and CMDs, as well as the interaction with psychosocial work environment. The goal is to show that routinely collected data can be used to a) identify risk factors for CMD, b) identify workplaces with high risk of sickness absence and c) give the employer recommendations on how to design healthy schedules. We have established a cohort of over 60,000 individuals employed by Stockholm Region between 2008 and 2021. Detailed information on working hours is retrieved from registry-based payroll data for each working day during the study. You will use longitudinal multivariate analysis to investigate working hours in relation to CMD and sickness absence, also including interaction between working hours and psychosocial work environment. In a non-randomized pseudo trial design, we will study the effect of changing work schedules on CMD. Finally, we will use ensemble methods to identify models that can predict workplace risk of long-term sickness absence among employees. The employment is temporary for two years.

Last Application Date: 14.Aug.2022

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31. Postdoctoral Researcher in protein biochemistry and biotechnology

Summary of Postdoctoral Fellowship:

We work on making artificial spider silk and base our work on biotechnology and protein biochemistry. Our lab has invented the first method for producing artificial spider silk fibers and our current main research focus lies in improving the mechanical properties of these by protein engineering and development of the spinning device. The group is well funded by e.g. an ERC consolidator grant. By using next generation sequencing technologies we have increased our understanding of the silk production machinery and will use this knowledge to improve the artificial spider silk fibers further. We have published several articles in high ranked journals (Arndt et al. Adv Funct Mater. 2022; Rising & Johansson ACS Nano. 2021; Schmuck et al. Materials Today. 2021; Andersson et al. Nat Chem Biol. 2017; Kronqvist et al. Nat Commun. 2017; Rising&Johansson. Nat Chem Biol. 2015). The group consists of three PhD students, two technicians, four post docs and one researcher. We are located at Karolinska Institutet, campus Flemingsberg, and at SLU in Uppsala.

Last Application Date: 14.Aug.2022

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32. Up to two Postdoctoral Researchers in experimental psychology with a focus on the behavioral defense against disease

Summary of Postdoctoral Fellowship:

We are currently looking for up to two postdoctoral researchers who will be working on several research projects in a research group lead by Professor Mats J. Olsson in close collaboration with Research specialist Arnaud Tognetti with a focus on the behavioral defense against disease. Behavior is arguably a cost-effective and first-line defense against disease. Using primarily experimental design (IRL and web-based), we investigate the physiological (including fMRI and immune response markers), perceptual, motivational and emotional processes that promote adaptive behavior in relation to sick kin and strangers.

Last Application Date: 07.Aug.2022

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33. ERC fundend postdoctoral scholarship: Exploring drivers of intratumor heterogeneity and phenotypic plasticity

Summary of Postdoctoral Fellowship:

We are seeking a motivated, creative post-doctoral candidate interested in exploring drivers of intratumor heterogeneity and phenotypic plasticity in sympathoadrenal tumors, such as childhood neuroblastoma and pheochromocytoma. Intratumor heterogeneity and high plasticity account for therapy resistance. Causes of plasticity cell state transitions during tumor progression remain poorly understood. Currently, there is no effective treatment that addresses cancer heterogeneity. Systematic characterization of dynamic properties of intratumor heterogeneity and phenotypic plasticity can guide treatment strategies and improve clinical outcome for cancer patients. We aim at elucidating the origin and heterogeneity of sympathoadrenal malignancies, such as pheochromocytoma and childhood neuroblastoma by developing a new analytic and experimental approach based on single-cell transcriptomics with integrated mass spectrometry. We generated novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

Last Application Date: 07.Aug.2022

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