32 Postdoctoral Fellowships at Roswell Park Cancer Center, New York

Are you holding PhD degree and looking for Postdoctoral Fellowships? Roswell Park Cancer Center, New York, USA inviting application for multiple Postdoctoral Fellowships. Roswell Park Cancer Center, New York is one of the largest research center in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.

Roswell Park Cancer Center has huge a campus in New York, USA and widely known as for its contribution in top notch education and research. The contribution of Roswell Park Cancer Center is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow/Associate position is available in the laboratory of Dr. Lori (Chia-Hsin) Chan in the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center. The appointment will start in July or later, 2021. We are seeking for self-motivated, collaborative individuals to join our group. The primary research will focus on studying the molecular basis that underlines tumor metabolism, metastasis, and immune responses. The candidate will have opportunities to participate the development of new therapeutic interventions used for cancer treatment. We will provide the new member the multidisciplinary training in molecular biology, cellular biology and various mouse model systems including xenograft, syngeneic and transgenic mice. Our previous and current postdoctoral fellows and graduated student have had first and/or co-author in high impact journals and have been recognized by various national accolades including fellowship awards and/or travel awards. We sincerely welcome young individuals who are enthusiastic in translating creative research ideas from bench to animals and ultimately to bedside.

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral position is open for a highly motivated candidate in the laboratory of Dr. AJ Robert McGray in the Department of Immunology. The project will focus on developing and optimizing strategies for the delivery of immune cell engagers (e.g. BiTEs) targeting the tumor and/or tumor stroma as potent cancer immunotherapies. The selected individual will use both in vitro systems and in vivo mouse models to develop, validate, and therapeutically test immune cell engagers. While a primary focus of this research will be to develop therapies that can be translated clinically to treat ovarian cancer, projects are anticipated to be broadly applicable to other tumor indications and will involve parallel studies in other disease areas. Experiments will involve the analyses of immune cell changes in response to immune cell engagers and will require use of preclinical models and primary clinical specimens to test candidate therapies. The successful candidate will be involved in all aspects of project design and research, preparation of scientific manuscripts and grant applications, and is expected to develop first author papers and contribute (as a co-author) to publications by other team members.

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Renier Brentjens in the Department of Medicine is looking for a postdoctoral candidate to work on a research project aiming to generate novel chimeric antigen receptor (CAR) T cells specifically targeted to antigens for the treatment of cancer. The specific research project involves usage and identification of antigens for targeted cell therapies, CAR design, and experimental models to validate antitumor capacity. The selected individual will perform studies in human in vitro models (and potentially mouse in vitro and in vivo models) to validate and enhance ability of CAR T cells to be used as effective cell therapy. The experiments will involve the analyses of immune cell functions and may involve mouse models of cancer. The candidate will be involved in preparation of scientific manuscripts and grant applications, with the expectation of developing first author papers and contributing (as a co-author) to papers of other members of the team.

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Andrew Goey is looking for a highly motivated and clinically oriented postdoctoral fellow to work on improving cancer treatments by pharmacogenetics. Research that will be carried out is highly translational and include genetic association studies, clinical trials, and in vitro drug metabolism experiments. The preferred candidate will have a track record of publications in the fields of pharmacogenetics and clinical pharmacology. Expected duties of the postdoctoral fellow include management and conduct of pharmacogenetic research projects, assistance in writing manuscripts, mentoring junior lab members, and applying for independent fellowship funding. Working in the laboratory of Dr. Goey will offer the successful candidate the unique opportunity to build his/her career in an inspiring multidisciplinary setting by collaborating with many of Roswell Park’s Shared Resources and clinicians at an NCI Comprehensive Cancer Center.

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5. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Department of Pediatric Oncology is seeking a full time Postdoctoral Fellow in the laboratory of Dr. Nataliya Buxbaum. The Buxbaum lab focuses on immunometabolism as it relates to hematopoietic stem cell transplantation (HSCT) and cellular immunotherapies. Our bench-to-bedside laboratory and clinical investigations are centered on graft-versus-host disease (GvHD) with a goal of developing new imaging and therapeutic modalities for this condition (Assmann, J.C. et al. Blood, 2021 https://pubmed.ncbi.nlm.nih.gov/32785680/; Mhandire, K. et al. Metabolites, 2021 https://www.mdpi.com/2218-1989/11/11/736; Buxbaum, NP, et al. Journal of Clinical Investigation Insight, 2017 https://insight.jci.org/articles/view/92851).

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Goodrich lab at Roswell Park Comprehensive Cancer Center is looking for a highly motivated postdoctoral fellow to study prostate cancer lineage plasticity (see Ku et al. Science 2017, Mu et al. Science 2017, Pearson et al. Cancer Cell, 2021). The postdoc will work with a dynamic team of clinicians and scientists to perform both pre-clinical experiments and clinical trial correlative studies aimed at both understanding mechanisms underlying prostate cancer lineage plasticity and targeting them for therapeutic benefit.

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Sung Lab at Roswell Park Comprehensive Cancer Center is seeking a postdoctoral fellow to study therapeutic resistance to targeted therapy in acute myeloid leukemia. Dr. Sung has a joint appointment in the Department of Medicine (Leukemia Service) and the Department of Pharmacology & Therapeutics. The overall goal of the lab is to develop novel therapeutic strategies for translation to early phase clinical studies in AML. Our current focus is on FLT3 inhibition and its role in modulating the epigenetic state and myeloid differentiation in AML (supported by NCI K08).

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoc position is available immediately, in Dr. Sayan Chakraborty’s laboratory to study an exciting project that investigates the in-depth molecular and biochemical mechanisms of the oncogenic action of Agrin. The Chakraborty lab is commencing at Roswell Park in the summer of 2022. Previous studies from our group have shown that Agrin acts as a master regulator of mechanotransduction via YAP/TAZ activation and ‘outside-in communications’ via engagement of integrin-focal adhesion complexes in cancer cells. Using liver cancer models, we have recently observed that Agrin shapes up the mechanical landscape of the tumor microenvironment (TME) and modulates tumor angiogenesis by stabilizing VEGFR2. Some of our key publications are listed here (Nat Commun. 2015 Jan 29;6:6184; Cell Rep. 2017 Mar 7;18(10):2464-2479; Cancers (Basel). 2018 Feb 6;10(2):45; Cell Rep. 2019 Jul 23;28(4):949-965; Trends Cancer. 2020 Feb;6(2):81-85; Nat Commun. 2021 Nov 3;12(1):6349).l

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

We are seeking an enthusiastic and talented candidate with a Ph.D. in neuroscience, engineering, computer science, cognitive psychology, the biomedical sciences, or a field related to neuroscience to join the Mind Maps Project at the Applied Technology Laboratory for Advanced Surgery (ATLAS) Program at Roswell Park Comprehensive Cancer Center in Buffalo, NY. We are planning to start a new artificial intelligence lab at Roswell Park and this candidate will be actively involved in this initiative. We are broadly interested in researching medical and surgical challenges. Projects in our lab include, but are not limited to, surgeons’ surgical skill evaluation in robot-assisted surgery environment by using surgeons’ physiological data, mental health evaluation of cancer patients after oncologic surgery, and rehabilitation progress monitoring.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

We are seeking an enthusiastic and talented candidate with a Ph.D. in cancer biology, genetics, molecular biology, experimental therapeutics, bioinformatics or related field. Perform a variety of routine and specialized lab tests and experimental procedures. Have access to patient database, tissue specimen, cell culture, patient-derived xenograft, next-generation sequencing and genetic mouse model. Assist with writing animal and human trial protocols, manuscripts, and grants.

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow/Associate position is available in the laboratory of Dr. Hai Wang in the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center. The appointment will start in August or later, 2022. The Wang lab focuses on studying the molecular basis that underlines tumor-microenvironment interaction in bone and other metastases of breast and prostate cancer. State of art facilities such as metabolomics, genomics, and sophisticated bone metastasis models are widely used in the laboratory. Multiple model systems, including Genetically Engineered Mouse Models (GEMMs), patient-derived xenograft (PDX), and syngeneic tumor models are used to address challenging mechanisms in cancer. Currently, the laboratory is stably funded by NIH and Foundation sources.

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12. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Our team is interested in translational research that uses physiological data to develop prediction models to improve cancer patients’ quality of life. We are seeking a highly motivated candidate to Contribute to data analysis and development of prediction models using one of these platforms: Python, Matlab, or R. Work closely with the team to develop peer-reviewed journal and conference drafts.

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Marco Davila in the Department of Medicine is looking for a postdoctoral candidate to work on a research project aiming to generate novel chimeric antigen receptor (CAR) T cells specifically targeted to antigens for the treatment of cancer. The specific research project involves the usage and identification of antigens for targeted cell therapies, CAR design, and experimental models to validate antitumor capacity. The selected individual will perform studies using in vitro models to validate and enhance the ability of CAR T cells to be used as effective cell therapy. The experiments will also involve the analyses of immune cell functions and mouse models of cancer. The candidate will be involved in preparing scientific manuscripts and grant applications, with the expectation of developing first-author papers and contributing (as a co-author) to papers of other team members.

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow position is available in the laboratory of Dr. Ethan V. Abel in the Department of Molecular and Cellular Biology. Position offers independence as well as important collaborative opportunities. Research will focus on the functional characterization of transcriptional/epigenetic regulators and signaling proteins in pancreatic cancer, and how these cellular components regulate drug resistance, cancer stem cells, metastasis, and metabolism to drive the disease. The laboratory’s research places equal emphasis on basic, mechanistic discovery and translational/preclinical research. Regularly implemented techniques include protein biochemistry, tissue culture techniques (including primary cells and organoids), cell proliferation/cell cycle assays, apoptosis assays, flow cytometry, PCR, RT-PCR, human/mouse xenografts, chromatin immunoprecipitation (ChIP), ChIP-seq, RNA-seq, ATAC-seq, DNA cloning and lentivirus/adenovirus-based gene delivery. Multiple established projects are available. Self-motivated and detail-oriented individuals with appropriate training background in cell and molecular biology are encouraged to apply. Position is available immediately. Roswell Park Cancer Institute (RPCI) provides a state-of-the-art research environment that includes 23 research core facilities and active collaboration with clinical groups. RPCI is America’s first cancer center and the only National Cancer Institute (NCI)-designated Comprehensive Cancer Center in upstate New York.

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15. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position in molecular epidemiology is available in the research program of Li Tang, PhD. Dr. Tang is an Associate Professor in the Department of Cancer Prevention and Control at Roswell Park Cancer Institute, Buffalo, NY. The fellow will work closely with Dr. Tang and with intramural and extramural collaborators. The research questions of interest include: 1) How do diet and genes interact to affect cancer treatment outcomes? 2) How do genetic variants contribute to racial differences in cancer characteristics and prognosis? 3) What is the role of human endogenous retrovirus in cancer development? The fellow will be mentored with an emphasis on analytic, writing, and other research skills in order to facilitate his/her transition to an independent investigator.

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16. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Identification and Functional Analysis of Novel Genetic Interactions and Vulnerabilities in KRAS Mutant Solid Tumors. The Cancer Genetics and Genomics Department at Roswell Park Cancer Institute is searching for an ambitious PhD biologist for a postdoctoral research project in the Identification and Functional Analysis of Novel Genetic Interactions and Vulnerabilities in KRAS Mutant Solid Tumors. Projects will be oriented around one or some combinations of the following topics: identification and characterization of novel tumor suppressor genes and/or oncogenes; and the study of their dysfunction mechanisms (focusing on epigenetics and tumor metabolism) in lung cancer and/or pancreatic cancer (e.g., using cell culture, animal models). Genomic screening using custom lentiviral CRISPR or other small RNA libraries in xenograft models. Pre-clinical therapeutic studies for development of data to support early phase clinical trials. Self-motivated and detail-oriented individuals with appropriate training background in cell and molecular biology are encouraged to apply. The candidate’s research would be supervised by Edwin Yau, MD, PhD, Assistant Professor of Oncology. Position offers independence as well as important collaborative opportunities. Position is available immediately. Roswell Park Cancer Institute (RPCI) provides a state-of-the-art research environment that includes 23 research core facilities and active collaboration with clinical groups. RPCI is America’s first cancer center and the only National Cancer Institute (NCI)-designated Comprehensive Cancer Center in upstate New York. (posted 9/2/18)

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17. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Translational Glycomics K12 program is currently accepting and considering applications from outstanding and motivated scholars. This program is intended for MD, MD/PhD, and PhDs at postdoctoral level for career development into independently funded researchers specializing in translational glycosciences. Each scholar is required to spend at least 2 years, limited to 3 years in the program. Each applicant will be evaluated independently, and program designed on an individual basis. Clinical MD’s must be able to devote 75% or greater time into the Program.

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

A grant-funded postdoctoral research affiliate position is available in the Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center. The focus of the research program is the genomics of tumor suppression due to endogenous and mutant X-linked cancer antigens. This position is ideal for a candidate with a strong biology background with significant solid technical experience. Our lab uses modern NGS techniques (bulk and single cell RNAseq), protein-protein methods and integrative genomics/bioinformatics and has expertise in comparative genetics and genetic epidemiology. The incumbent will have the opportunity to craft a project supported by a multidisciplinary team of scientists, computational biologists and clinicians. The Eng group is a computational biology research group working with big genomic data in the context of immune targets and biomarkers. Close collaborators include clinical and research groups in therapy resistance, immunotherapy and epigenetics.

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral research affiliate position is available in the Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY. The focus of the research program is the genomics of tumor suppression and tumor surveillance involving mouse models of prostate cancer, and correlative patient studies. This position is ideal for a researcher with a strong background in biology and interested in additional bioinformatics training. The incumbent will direct or manage independent projects in the bench portion of the laboratory feeding back into bioinformatics with the opportunity for increasing informatics responsibilities. Alternatively, applicants with terminal degrees in statistics, computer science, or data science with a demonstrated interest in cancer genetics and an interest in a career in cancer biology are encouraged to apply. The incumbent will work with a multidisciplinary team of scientists, computational biologists and clinicians. The Eng group is a computational biology research group working with big genomic data (bulk RNAseq, scRNAseq, protein-protein interaction) in the context of immune targets and biomarkers. Close collaborators on these projects include Nastiuk lab which focuses on therapy resistance in mouse models, the Krolewski lab on immune surveillance, and the Chatta group on clinical GU immuno-oncology.

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20. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Applications are sought for a Post-Doctoral or Research Associate position in the Department of Cancer Prevention and Control at Roswell Park Comprehensive Cancer Center. The candidate will take part in NIH-funded projects on HPV infection and related diseases in high-risk populations. Projects include a large HPV vaccine surveillance study of inner-city minority youth, and a prospective study of oral HPV and the microbiome in HIV+ individuals. The candidate is expected to analyze data, publish papers, assist with preparing grants, and help supervise graduate and undergraduate students. The position will be for a period of 2 years, with possibility of extension, and comes with a competitive salary and attractive benefits.

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Joseph Barbi in the Department of Immunology is looking for a postdoctoral candidate to pursue research projects aimed at exploring the mechanisms responsible for immune suppression and activation in the cancer setting with a particular emphasis on how obesity impacts these mechanisms. The postdoctoral fellow will assist in the execution of studies being carried out in the Barbi lab and that of collaborators (also at Roswell Park). These studies will utilize in vitro and in vivo assays of immune cell function, mouse models of both cancer and immune-mediated pathologies (i.e., autoimmunity), and the analysis of clinical samples. The ability of experimental agents and treatments to boost natural and therapy-induced anti-tumor immunity will also be explored.

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The primary focus will be to carry out research activities as outlined by your mentor in GI/Endocrine malignancies. Access to weekly didactics, journal clubs, preoperative conferences along with complex general surgical oncology fellowship trainees Exposure to operative cases including Minimally Invasive Robotics surgery (Optional)

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Our laboratory studies and develops adoptive T cell therapies targeting solid tumors. The postdoctoral scientist will focus on developing genetically engineered T cells starting from the molecular cloning phase of cell therapy development, and then advancing to preclinical in vitro work and clinically relevant mouse models. A strong background in immunology and molecular biology will allow the successful applicant to be creative within the lab, enhancing T cell function and tumor targeting for optimal patient translation and high impact publication. The postdoctoral scientists will work within the Center for Immunotherapy, which holds multiple institutional level grants and houses multiple investigators – including immunologists, molecular biologists, and computational biologists – dedicated to developing immunetherapies. Strong support for career development and academic and educational activities are included.

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24. Two Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Position #1 is focused on studying the role of retinoblastoma tumor suppressor pathway (RB, p16ink4a, and cyclin D1) in breast cancer. Specific emphasis will be placed on the role of RB loss in disease progression and therapeutic response. This work will incorporate the use of cell culture, animal models, and clinical specimens. Position #2 is focused on deciphering mechanisms through which breast cancers evade standard therapies and elucidate new approaches for therapeutic intervention using targeted approaches. These studies will use PDX, organoid, and mouse models.

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The connection between Indigenous peoples and the natural environment has important ancestral, historical, cultural, and health related elements. The Roswell Park Center for Indigenous Cancer Research seeks a postdoc to collaborate in project(s) development across tribal areas dedicated to environment, human exposure and the human condition as they relate to cancer health issues and population science. We seek applications from a researcher who has worked and has experience with Indigenous populations, bench or basic science, cancer health disparities, and environmental research. The work will be community-based, community-driven, and seek to advance the understanding towards solutions related to environmental challenges and concerns including but not exclusive to environment and human exposure, land-based learning and public health at the tribal, local, regional, national, and international levels. The projects and position will engage by means of a participatory and tribally driven fashion with Indigenous community partnerships including tribal workforces and tribal environmental programs. The evolving research will make contributions to scientific knowledge that may include basic scientific research and outcomes that will translate to the Indigenous experiences and understandings of cancer disparities related to environment and the human condition. Altogether, the postdoc role includes the development of research partnerships and collaborative research efforts related to the natural environment (e.g., soil, water, wind) for Indigenous decreasing cancer and co-occurring health disparities within Indigenous landscapes and/or Indigenous urban settings.

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral position is open for highly motivated candidates in the laboratory of Dr. Subhamoy Dasgupta at the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, NY- a National Cancer Institute (NCI) designated comprehensive cancer center. The Dasgupta lab focuses on discovering novel tumor metabolic adaptations, and investigates associated biological mechanisms such as transcriptional regulation, nuclear receptor and steroid hormone action, nutrient signaling, mitochondrial biology, epigenetics, and tumor immunology in the progression of cancer metastasis (Sawant Dessai A, et al, Under Review, 2020; Dasgupta S, et al, Nature, 556, 249–254, 2018; Dasgupta S, et al, Journal of Clinical Investigation, 125(3):1174-88, 2015). State of art facilities such as proteomics, genomics, and metabolomics along with molecular biology techniques are widely used in the laboratory. Multiple models systems, including Genetically Engineered Mouse Models (GEMMs), patient-derived xenograft (PDX), and syngeneic tumor models are used to address challenging mechanisms in breast and prostate cancer progression and metastasis. Currently the laboratory is stably funded by multiple grants from NIH/NCI, Susan G. Komen Breast Cancer Foundation, and other funding sources.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Our laboratory is broadly interested in transcriptional regulation and cell-fate determination in cancer cell biology and treatment. We are seeking a highly motivated and skilled candidate to work on a novel family of transcriptional and cell-fate regulators in cancer cell biology and treatment response, and stem cell biology. The candidate will be surrounded by a stimulating research environment, cutting-edge technology, and daily interactions with colleagues in other labs. The training environment will be one where regular discussion of new ideas, and freedom to explore new avenues of investigation, will be encouraged.

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28. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A research group at Roswell Park Comprehensive Cancer Center Department of Cancer Prevention and Control (Buffalo, NY) is looking for a postdoctoral research fellow, who is interested in academic research of cancer epidemiology, genomics, and cancer health disparities. The group is dedicated to cutting-edge population-based research to understand the biological underpinnings of cancer racial/ethnic disparities, with multiple active federal and private foundation funded research projects focusing on genomic, molecular, and cellular mechanisms underlying cancer health disparities in several large and unique racial/ethnic minority populations, as well as on cancer outcome and survivorship. The group has been generating a large amount of genomic and molecular datasets from these large patient populations that provides numerous training and research opportunities for manuscript writing, as well as the development of independent research proposals.

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29. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Multiple Myeloma/Amyloidosis Service of the Department of Medicine is seeking a full-time Postdoctoral Fellow in the laboratory of Dr. Jens Hillengass. The Hillengass lab focuses on the spatial heterogeneity of bone marrow infiltration of multiple myeloma. Using modern genomic DNA and RNA sequencing approaches as well as immunological analyses Dr. Maximilian Merz was able to show genes being differentially expressed in osteolytic lesions compared to the random bone marrow. Longitudinal samples showed transcriptional changes after treatment (Merz, M, et al, Annual Meeting of the American Society of Hematology, 2020; Manuscript in preparation). Furthermore, the group works on the utilization of modern imaging techniques for early detection of monoclonal plasma cell disorders and to analyze treatment response. Further projects deal with the influence of interventions like physical exercise and nutrition on the immune system and immunosurveillance in patients with monoclonal plasma cell disorders.

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30. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoc position is immediately available to study the biology of acute leukemia and perform preclinical evaluation of promising therapeutic approaches for acute leukemia. Candidates should be highly motivated and able to work independently in designing, performing, and analyzing experiments. Experience in data presentation (oral/poster) and writing skills are highly desired. Proficiency in laboratory skills includes flow cytometry, fluorescent microscopy, in vitro proliferation/cytotoxicity assays, western blots, RNA/DNA extraction and other molecular biology techniques are required. Candidates with prior experience working on tumor mouse models are preferred (but not required).

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The project will study the role of the HBP1-BRMS1-BRMSL1 axis in controlling breast cancer dormancy in the bone microenvironment. The project involves an in vitro 3D culture model that recapitulates bone endosteal or vascular niche microenvironments. As well, the project involves in vivo spontaneous and experimental breast cancer bone colonization models (orthotopic and intracardiac injections), in vivo monitoring of metastatic growth and signaling in the bone, and analysis of how the HBP1-BRMS1-BRMSL1 axis controls cell cycle progression genes through the SIN3A-mediated chromatin landscape.

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