35 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee

Are you holding PhD degree and looking for Postdoctoral Fellowships? St. Jude Children’s Research Hospital, Tennessee inviting application for multiple Postdoctoral Fellowships. St. Jude Children’s Research Hospital is one of the largest university in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.

St. Jude Children’s Research Hospital has huge a campus in Tennessee and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..

1. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Dr. Stan Pounds, a Member (Professor) in the St. Jude Department of Biostatistics, seeks a postdoc to pioneer the development and application of innovative data analysis methods in statistical cancer genomics and pharmacogenomics. In close collaboration with Drs. Charles Mullighan (St. Jude Pathology Department) and Jatinder Lamba (University of Florida College of Pharmacy), the successful applicant will develop and apply innovative statistical methods that integrate multiple forms of omic data (genomic, epigenomic, transcriptomic, proteomic, metabolomic) with multiple clinical outcomes (initial response, relapse-free survival, overall survival) to make fundamental biological discoveries that accelerate our progress towards curing childhood leukemias.

Last Application Date: Open until filled

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2. Postdoctoral Research Associate – Tumor Cell Biology

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development. The candidate will be offered an excellent research environment to work on novel candidates identified from our own CRISPR screens and integrative analysis of multidimensional datasets.

Last Application Date: Open until filled

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3. Postdoctoral Research Associate – Collaborative Research Program

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow position to work on in vitro biophysics studies of the biology and biophysics of RNP granules. We will be addressing the biophysical and biological consequences of the network structure underlying stress granules. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Rohit Pappu (Washington University in St. Louis). The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.

Last Application Date: Open until filled

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4. Postdoctoral Research Associate – Genetic Epidemiology and Pharmacogenomics

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoctoral Research Fellow to join the laboratory of Dr. Yadav Sapkota in the Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital. Successful candidates will work on projects related to pharmacogenomics of long-term toxicities of cancer therapy in childhood cancer survivors, supported by our new NIH R01 grant, in collaboration with Dr. Paul Burridge at Northwestern University (expert in using human induced pluripotent stem cells to study drug-induced toxicities). Specific research topics include 1) genetic association analyses (whole genome and whole exome sequence associations and polygenic risk scores) for various long-term health outcomes among survivors of European and African ancestries; 2) analyses of multi-omics (epigenomics, transcriptomics, proteomics, and metabolomics) and system genetics (e.g., eQTLs regulating molecular responses to cancer therapies in human induced pluripotent stem cells) data for elucidating molecular mechanisms for health outcomes; and 3) evaluating health disparities through pharmacogenomics.

Last Application Date: Open until filled

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5. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes.

Last Application Date: Open until filled

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7. Postdoctoral Research Associate – Infectious Diseases

Summary of Postdoctoral Fellowship:

The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.

Last Application Date: Open until filled

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8. Postdoctoral Research Associate – Oncology Collaborative Research Program

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies.

Last Application Date: Open until filled

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9. Postdoctoral Research Associate – Oncology Collaborative Research Program

Summary of Postdoctoral Fellowship:

Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

Last Application Date: Open until filled

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10. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.

Last Application Date: Open until filled

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11. Postdoctoral Research Associate – Cell & Molecular Biology

Summary of Postdoctoral Fellowship:

Dr. Kundu’s lab currently has an opening for a postdoctoral research fellow. The project will be to investigate the role of ulk1/2 in hematopoietic stem cells.

Last Application Date: Open until filled

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12. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. The department is seeking an outstanding postdoctoral fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer and mental health.

Last Application Date: Open until filled

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13. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate omics data related to innate immune signaling projects. The lab is particularly interested in dissecting signaling pathways and interactomes involved in innate immune responses and cell death (NLRs, inflammasomes). Knowledge and practical implementation of traditional machine learning and state-of-the-art deep learning techniques is essential. Understanding of working mechanisms of Alphafold2 and RoseTTAFold is highly appreciated. The tools and models built will be utilized to derive hypotheses which can be validated through in vitro and in vivo studies.

Last Application Date: Open until filled

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14. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system during viral infection. We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes) in response to viruses. The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. 

Last Application Date: Open until filled

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15. Postdoctoral Research Associate – Radiation Oncology

Summary of Postdoctoral Fellowship:

The primary focus of this postdoctoral research associate position is on using Big Data analytics tools to improve treatment plan quality in proton therapy. We are especially interested in understanding the roles of linear energy transfer and treatment plan robustness. As part of the Department of Radiation Oncology, the postdoctoral research associate will have access to world-class resources, including the world’s first proton therapy center with pencil-beam scanning technology that is designated solely for treating pediatric cancer, a detector-based spectral CT scanner that was the first in the world to be installed in a radiation oncology department, state-of-the-art 1.5T and 3T MR scanners, and a recently installed digital PET/CT scanner.

Last Application Date: Open until filled

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16. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology approaches. In particular, we study heterochromatin formation and the chromatin-modifying proteins involved in this process. We use cryo-EM methodologies to examine processes involved in chromatin organization and also apply genetics and molecular biology approaches to investigate heterochromatin formation in fission yeast.

Last Application Date: Open until filled

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17. Postdoctoral Research Associate – Epidemiology & Cancer Control

Summary of Postdoctoral Fellowship:

Dr. Zhaoming Wang, a joint faculty member between St. Jude Department of Epidemiology and Cancer Control and the Department of Computational Biology, is seeking highly motivated and creative candidates for a fully supported postdoctoral fellow position to conduct high impact clinical research primarily in genetic epidemiology of cancers (childhood and subsequent adulthood cancers), biomarker discovery for treatment- and/or aging-related late effects of survivors of childhood cancer, and omics-based precision preventive medicine. You will have the opportunity to work with large-scale whole-genome sequencing, whole-exome sequencing, epigenetic profile, and RNA sequencing data for a well-established cohort of childhood cancer survivors with clinically assessed rich set of phenotypes including subsequent neoplasms.

Last Application Date: Open until filled

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18. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

Last Application Date: Open until filled

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19. Postdoctoral Research Associate – Pharmaceutical Sciences

Summary of Postdoctoral Fellowship:

A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics.

Last Application Date: Open until filled

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20. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Please apply here, in addition to specific postings, if you would like your CV reviewed by multiple faculty. Also apply here if you have been requested to do so by a recruiter.

Last Application Date: Open until filled

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21. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project.

Last Application Date: Open until filled

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22. Postdoctoral Research Associate – Chemical Biology & Therapeutic 

Summary of Postdoctoral Fellowship:

We are recruiting a Postdoctoral Fellow (Medicinal Chemist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The medicinal chemistry efforts are expected to synergize with our pharmacology and structural biology efforts and enable publication of impactful papers (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021).

Last Application Date: Open until filled

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23. Postdoctoral Research Associate – Computational Biology

Summary of Postdoctoral Fellowship:

The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs.

Last Application Date: Open until filled

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24. Postdoctoral Research Associate – Biostatistics

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.

Last Application Date: Open until filled

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25. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity.

Last Application Date: Open until filled

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26. Postdoctoral Research Associate – Immunology

Summary of Postdoctoral Fellowship:

The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer. The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.

Last Application Date: Open until filled

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27. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study.

Last Application Date: Open until filled

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28. Postdoctoral Research Associate – Chemical Biology & Therapeutics

Summary of Postdoctoral Fellowship:

A unique postdoctoral fellow position is available immediately in the joint laboratory of Dr. Christopher Tinkle, Department of Radiation Oncology, and Dr. Anang Shelat, Department of Chemical Biology and Therapeutics, to apply state-of-the-art chemical biology and bioinformatics methodologies across diverse pediatric malignancies to investigate the molecular consequences of defective DNA repair, and to target these deficits using small molecules. This project leverages the institution’s world class repository of patient derived xenograft models and associated genomic and proteomic data sets. This work will directly support the institution’s translational program, with the goal of identifying clinically actionable drug-drug and drug-radiation combination strategies.

Last Application Date: Open until filled

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29. Postdoctoral Research Associate – Structural Biology

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries. We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors.

Last Application Date: Open until filled

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30. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021.

Last Application Date: Open until filled

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31. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

We aim to understand the functional organization of neural circuits that control movement, including how descending pathways from the brain interact with spinal circuits to implement motor output. The lab approaches this problem from multiple perspectives, using mouse genetics, single-cell transcriptomics, viral tracing and whole-brain imaging, and animal behavior to explore the role of molecularly discrete subsets of neurons in motor control. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, interactive, and supportive environment that provides the freedom to independently develop a research project.

Last Application Date: Open until filled

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32. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective. Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation.

Last Application Date: Open until filled

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33. Postdoctoral Research Associate – Collaborative Research

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.

Last Application Date: Open until filled

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34. Postdoctoral Research Associate – Hematology

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details.

Last Application Date: Open until filled

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35. Postdoctoral Research Associate – Developmental Neurobiology

Summary of Postdoctoral Fellowship:

During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization.

Last Application Date: Open until filled

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