Are you holding PhD degree and looking for Postdoctoral Fellowships? Penn University, Pennsylvania inviting application for multiple Postdoctoral Fellowships. Penn University is one of the largest university in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.
Penn University has huge a campus in Pennsylvania, USA and widely known as for its contribution in top notch education and research. The contribution of Penn University is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..
1. Postdoctoral Fellow Human Evolutionary Genomics/ single cell studies of immune response
Summary of Postdoctoral Fellowship:
The Tishkoff lab integrates genomic, transcriptomic, metagenomic, metabolomic, and epigenomic datasets generated from a large sample of ethnically diverse Africans, African Americans, and African immigrants in the US (http://www.med.upenn.edu/tishkoff/). We use evolutionary, statistical, population genetics and functional genomics approaches to understand the genetic architecture of a number of anthropometric, cardiovascular, metabolic, and immune related traits for which we have detailed phenotype data. We are seeking postdocs focused on computational biology, functional genomics and/or single cell studies of immune response. The candidate for the computational position will be involved in inferring the demographic history of African populations, determining the genetic basis of adaptation during human evolutionary history, characterizing genetic and epigenetic factors influencing gene regulation in tissues and single cells in humans, characterizing variation from whole genome short and long-read sequencing data, and/or studying genotype/phenotype associations for complex traits.
Last Application Date: Open Until Filled
2. Postdoctoral Researcher
Summary of Postdoctoral Fellowship:
A postdoctoral position to design and perform research in equine sperm capacitation, oocyte maturation, intracytoplasmic sperm injection, embryo culture and vitrification, and/or other aspects of equine assisted reproduction. Participate in the research and clinical embryo production procedures in the laboratory. Perform data collation and statistical analyses, prepare abstracts, presentations and research papers. Perform and assist with procedures with horses including transvaginal ultrasound-guided follicle aspiration; organize and maintain mare herd. Process sperm, utilize staining procedures, perform flow cytometry, CASA, plate reader analyses. Process oocytes and prepare media. Perform transvaginal ultrasound-guided follicle aspiration. Should have some familiarity with procedures for oocyte maturation, intracytoplasmic sperm injection, embryo culture, embryo biopsy, embryo cryopreservation/warming, cell culture, sperm processing, embryo selection and packaging and related techniques. Keep accurate records of work performed. Utilize a computer and applicable software to create databases, perform statistical analyses, present data and perform other computer related tasks, record data. Coordinate student help; work cooperatively with others.
Last Application Date: Open Until Filled
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3. Postdoctoral Research Fellow Position in Neuroimaging in the Department of Radiology
Summary of Postdoctoral Fellowship:
A postdoctoral position for an MR physicist is available in the Division of Neuroradiology/Department of Radiology in the Cerebrovascular Lab (www.TheSongLabBrain.com) at the University of Pennsylvania. The position is to conduct research on multiplexed neuroimaging. We will use new deep learning-based processes that fuse multimodal images and create higher quality, data-rich medical images. Maximizing imaging data from each modality, we will then use machine learning to identify, validate and implement the use of neuroimaging biomarkers for neurologic disorders. This AI-fueled project will leverage the expertise of an interdisciplinary team to propel medical innovation towards more precise and personalized diagnostic strategies. The position requires focused expertise in the specific area of developing advanced MRI pulse sequences, image reconstruction/analysis methods and applying these techniques to neuroimaging for neurological disorders. These skills will be further supplemented with training in clinical translation and bioinformatics with the support of our interdisciplinary team of collaborating faculty at the University of Pennsylvania.
Last Application Date: Open Until Filled
4. Post-doctoral fellow
Summary of Postdoctoral Fellowship:
A postdoctoral position in exosomal checkpoint proteins as a biomarker to predict treatment response is available immediately. The research will also investigate the role of exosomes in myeloproliferative neoplasms using state-of-the-art technologies at the University of Pennsylvania. The postdoc will also have opportunities to work with a pharmaceutical company. Training will be provided.
Last Application Date: Open Until Filled
5. Postdoctoral Fellow — multimodal imaging in Alzheimer’s disease
Summary of Postdoctoral Fellowship:
The Penn Image Computing and Science Laboratory (PICSL) and the Penn Alzheimer’s Disease Research Center (ADRC) are seeking to recruit a postdoctoral fellow to engage in computational image analysis research focused on studying variability of imaging-based biomarkers of Alzheimer’s disease. The postdoctoral fellow will be working with ADRC faculty to analyze unique in vivo and postmortem imaging datasets using novel image registration, segmenta-tion, morphometry, and machine learning techniques. Candidates should have completed (or be about to complete) a Ph.D. in a relevant field of study and have a strong interest in neurodegenerative disease research.
Last Application Date: Open Until Filled
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6. T32 Postdoctoral Trainee – Translational Neuroimaging in ADRD
Summary of Postdoctoral Fellowship:
Training Program Summary: Neuroimaging has become a leading strategy used for translational research in Alzheimer’s disease and related dementias (ADRD), as well as a prominent biomarker strategy for defining preclinical stages of ADRD, for clinical differential diagnosis of ADRD, and for evaluating for target engagement and therapeutic responses in clinical trials. Modern neuroimaging is an inherently interdisciplinary field combining expertise in neuroscience, biostatistics, and bioengineering. Additional expertise in topics such as genomics and basic science disease mechanisms are also required to translate neuroimaging in ADRD research. This proposed cross-disciplinary training program will provide two years of support for predoctoral and postdoctoral trainees from both biological and quantitative science backgrounds with the training required to develop a research career focusing on neuroimaging in ADRD. A core course curriculum will cover neuroimaging methods and additionally include specialized training in the Responsible Conduct of Research, Experimental Rigor, and Transparency and its application to neuroimaging.
Last Application Date: Open Until Filled
7. Postdoc Position – Environmental, Genetic, and Lifestyle in Neurodegeneration
Summary of Postdoctoral Fellowship:
The University of Pennsylvania (UPenn) Frontotemporal Degeneration Center (FTDC) is currently seeking a qualified applicant for a postdoctoral fellowship. The overall mission of the Penn FTDC is to use integrative strategies to leverage multimodal data such as neuropyscholgical, neuroimaging and biofluid biomarker data to improve our understanding of the biological basis and heterogeneity of neurodegenerative conditions. We aim to identify environmental, lifestyle and genetic associations that can be used to understand variability in cognitive decline, uncover mechanisms of disease and/or stratify diverse patients to define homogenous patient groups with a higher likelihood of achieving a therapeutic response. We primarily focus young-onset neurodegentiave conditions such as frontotemporal lobar degeneration (FTLD).
Last Application Date: Open Until Filled
8. Postdoctoral fellowships
Summary of Postdoctoral Fellowship:
The Morrisey Lab is an integrated team of postdoctoral fellows, physician-scientists, students, and researchers whose goal is to better understand the cellular and molecular etiology of lung disease and regeneration. We have an open postdoctoral fellowship position to study lung regeneration. The ideal candidate will have a Ph.D., M.D., or both with experience in genetic models of stem/progenitor cell development and activation after injury. Additional experience in organoid modeling of stem cell behavior, single cell genomic analysis, and imaging are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.
Last Application Date: Open Until Filled
9. Cancer Genetics Postdoctoral Position
Summary of Postdoctoral Fellowship:
The Maxwell Laboratory is seeking a highly motivated and creative postdoctoral fellow to understand the role of inherited TP53 mutations and interactions with the immune system in breast tumor development. The PI, Dr. Kara Maxwell, runs the Li Fraumeni Syndrome (LFS) Biobank at Penn Medicine, which ascertains patients with inherited mutations in the tumor suppressor TP53. The LFS biobank contains extensive clinical information, germline and tissue samples, peripheral blood mononuclear cells, and lymphoblastoid cell lines created from patients. Our studies have shown that certain hypomorphic TP53 mutations lead to high risks of breast cancer. Using knock-in breast cancer cell lines and patient derived lymphoblastoid cell lines, the postdoctoral fellow will characterize p53 pathway defects associated with these alleles. The fellow will utilize mouse models to study breast tumor development due to these TP53 mutations, both xenograft models and CRISPR knock-in models. Finally, the fellow will investigate the humoral and cellular responses to breast cancer development in our patient samples.
Last Application Date: Open Until Filled
10. Mechanisms of hemostasis and thrombosis
Summary of Postdoctoral Fellowship:
Two Post-Doctoral Scholar positions are available for NIH-funded studies on platelets and vascular biology. The Brass lab uses a combination of cell biology, mouse models, computational models, and in vivo imaging to answer basic and translational questions about hemostasis, thrombosis, cell signaling, and the role of platelets in maintaining vascular integrity. The lab exists within a vibrant community of investigators at Penn and Children’s Hospital of Philadelphia with shared interests (and research) in platelet, coagulation factor and vascular biology and is supported by a multi-investigator program project grant based at Penn. Participating laboratories meet weekly and share an NIH HLBI T32-funded training program.
Last Application Date: Open Until Filled
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11. Postdoctoral Fellow Cancer Chemical Biology
Summary of Postdoctoral Fellowship:
The Brady lab led by Dr. Donita Brady is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. We are currently recruiting three postdoctoral fellows to join our research program at Penn. Our research program at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas. Our focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development. The emergence of this new paradigm in nutrient sensing and protein regulation has established that Cu is a critical mediator of intracellular signaling, provided evidence for the existence of molecular mechanisms for sensing changes in Cu abundance, and expanded the contribution of Cu to cellular processes necessary for adaptation to nutrient scarcity.
Last Application Date: Open Until Filled
12. Postdoctoral Researchers
Summary of Postdoctoral Fellowship:
Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. Our lab is interested in cancer, stemness, and neurodegeneration. The current projects focus on two areas: (1) The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed an important role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. Furthermore, we are identifying and characterizing metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells.
Last Application Date: Open Until Filled
13. Postdoctoral fellow in molecular virology
Summary of Postdoctoral Fellowship:
Our collaborative team studies the molecular biology of human papillomaviruses (HPVs). Our goal is to understand the molecular mechanisms by which HPVs modulate host cell processes and cause cancer. Projects are available in several broad areas. We use molecular and cell biological techniques as well as computational biology, mass spectrometry, high-throughput screening approaches, and more to investigate HPV biology. For examples of our recent work, see PNAS (2019) 116:7033-7042 and eLife (2022) 11:e75466. The Perelman School of Medicine provides an outstanding environment for postdoctoral training. Our colleagues include world-class physicians and basic scientists. Penn is home to outstanding tumor virology laboratories, the Abramson Cancer Center, and the Tumor Virology Program. There are abundant opportunities for collaboration with these and other groups at Penn, and at neighboring institutions.
Last Application Date: Open Until Filled
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14. Post Doctoral Fellow
Summary of Postdoctoral Fellowship:
The Dodge Translational Orthopaedic Research Laboratory at the McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery at the University of Pennsylvania is seeking an individual to fill a full time Research Post-Doctoral position. The position will be in part to support the research operation of Mechano Therapeutics a UPenn spinout company The position involves working with team of scientists comprised of Drs. George Dodge, Nick DePhillipo, Robert Mauck and Daeyeon Lee in our laboratories at the University of Pennsylvania and the Mechano Therapeutics lab at Pennovation Center. This is an exciting opportunity for the person that wants experience in developing new technology that spans both the basic science and practical aspects that are part of a rapidly emerging company. This position is focused a novel therapeutic delivery platform technology that is centered on mechanically activated microcapsules (MAMCs) and therapeutic delivery to various areas of the musculoskeletal system.
Last Application Date: Open Until Filled
15. Postdoctoral Fellow
Summary of Postdoctoral Fellowship:
The position calls for a highly motivated candidate with a strong background in neurobiology, molecular biology and/or cellular biology. Experience working with rodent models of glaucoma or retinal degeneration, electrophysiology, molecular and cellular neurobiology, gene editing with CRISPR/Cas9 expertise and in vitro cell culture experiments including stem cell or iPSC derived culture are desired. Good oral and written communication skills are required. Responsibilities include designing and conducting experiments, analyzing data, preparing and presenting research findings at meetings, helping to write scientific manuscripts, and applying for fellowships/grants.
Last Application Date: Open Until Filled
16. Postdoctoral fellow
Summary of Postdoctoral Fellowship:
A Postdoctoral Researcher position is available for highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focus is understanding resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), understanding how to sequence DDRi with Immuno-Oncology (IO) drugs, and identifying biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX), patient derived organoid, and primary tumor cultures from ovarian and endometrial cancers. These PDX models minic the original tumor, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer creating an autologous in vivo model system.
Last Application Date: Open Until Filled
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17. Postdoctoral research fellow
Summary of Postdoctoral Fellowship:
A postdoctoral research fellow position is available in the laboratory of Dr. Kate O’Neill, at the University of Pennsylvania (Penn). Our lab is part of the rich scientific environment on the Penn/CHOP campus that includes expertise and research interest in cancer, reproductive medicine, epigenetics, stem cell biology and emerging technologies. We are located in the Biomedical Research Building as part of the Department of Obstetrics & Gynecology and Center for Research on Reproduction & Women’s Health (CRRWH). The lab’s research focuses on spatial ‘omics of the female reproductive tract, endometrial regeneration and implantation. Due to the robust clinical research present at Penn we have unparalleled access to a human model of uterus transplant which we are currently leveraging to answer fundamental questions about endometrial biology and the maternal-fetal interface. The laboratory work is part of a larger translational research program in which patient samples and clinical data are collected from multiple centers performing uterus transplantation. The position provides the opportunity for extensive interdisciplinary interactions with other groups within the CRRWH and UPenn working on related and complimentary topics.
Last Application Date: Open Until Filled
18. Post Doctoral Researcher
Summary of Postdoctoral Fellowship:
The Modzelewski Lab at the University of Pennsylvania Department of Biomedical Sciences School of Veterinary Medicine is recruiting Post-doctoral researchers to join an exciting new NIH-NICHD funded project. Our work focuses on the exciting and emerging role of retrotransposons in early development (and beyond). We are looking at how retrotransposons impact fertility and preimplantation development in mice but with comparative biology studies using various placental mammalian species to learn about human health and reproduction.
Last Application Date: Open Until Filled
19. Postdoctoral fellow in human tumor immunology
Summary of Postdoctoral Fellowship:
We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.
Last Application Date: Open Until Filled
20. Postdoctoral Fellow – Environmental Epidemiology
Summary of Postdoctoral Fellowship:
A Postdoctoral Fellow position in Environmental Epidemiology is available in the Department of Biostatistics, Epidemiology, and Informatics (DBEI) at University of Pennsylvania Perelman School of Medicine. The candidate will be involved in NIH funded epidemiologic research projects which examine environmental toxicant exposure and reproductive, perinatal and pediatric health outcomes, including pregnancy outcomes, child neurobehavior, and child cardiometabolic endpoints and new epidemiological methods. The environmental toxicants of interest include endocrine disrupting chemicals, heavy metals, persistent organic pollutants, air pollution, and chemical mixtures. The candidate will embark on all activities of epidemiologic research with the goal of fostering a future as an independent leader in the field. The University of Pennsylvania has a P30 Center of Excellence in Environmental Toxicology (CEET) and a T32 Translational Research Training Program in Environmental Health Sciences funded by the NIH/NIEHS.
Last Application Date: Open Until Filled
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21. Postdoctoral position in Cardiovascular Research
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.
Last Application Date: Open Until Filled
22. Postdoctoral
Summary of Postdoctoral Fellowship:
The Bhoj Laboratory, a member of Penn’s Center of Cellular Immunotherapies (CCI), is looking for postdoctoral candidates interested in translational research focused on development of novel T cell immunotherapies. The over goal of the lab is to develop of CAR T cells and other platforms of engineered T cell-based immunotherapies for the treatment of diseases or conditions that are driven by pathogenic immune responses. The overarching premise is centered on the notion that T cell therapies offer several advantages in regard to target cell elimination and immunomodulation where traditional pharmacologic therapies fall short. Existing projects are focused on targeting B cells, plasma cells and T cells that drive autoimmune responses as well as allo-immune responses (e.g. anti-drug antibodies and organ/tissue allograft rejection. Several projects synergistically combine engineered T cell platforms with other biologicals or targeted small molecules for enhanced immune-modulation.
Last Application Date: Open Until Filled
23. Post-doctoral fellow
Summary of Postdoctoral Fellowship:
The Wexler Lab at the Department of Medical Ethics & Health Policy at the Perelman School of Medicine at the University of Pennsylvania is seeking a full-time postdoctoral fellow in neuroethics. This 12-month position will begin in fall 2022; there is a possibility for renewal contingent upon funding. The fellow will work on an NIH-funded project that utilizes sociological methods to study the ethical, legal, and social implications of neurotechnology. The post-doctoral fellow will be able to participate fully in the life of the Department, which is among the world’s leading centers of bioethics research and teaching. The fellow will have full access to the intellectual resources of the Penn community. There may be the potential for the fellow to obtain core training in bioethics by participating in a weekly bioethics proseminar led by the Division Chief.
Last Application Date: Open Until Filled
24. Post-doc in Translational Chronobiology
Summary of Postdoctoral Fellowship:
The Weljie Lab in the Department of System Pharmacology and Translational Therapeutics at the University of Pennsylvania is seeking multiple highly motivated and independent post-doctoral fellows to help drive our program in quantitative metabolic profiling in chronobiology and translational research. Applicants with a wide variety of previous training are encouraged to apply. The focus of their work will be investigation of sleep and circadian biology as they relate to metabolism. Our lab applies analytical methods using mass spectrometry (LC-MS, LC-MS/MS, mass spec imaging and nuclear magnetic resonance, NMR) for comprehensive metabolite profiling and implementation of data analysis pipelines to a variety of model and clinical problems, including Drosophila, mice, and human samples.
Last Application Date: Open Until Filled
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25. Bioinformatics Research Position
Summary of Postdoctoral Fellowship:
The ITMAT Bioinformatics Laboratory is a bioinformatics research facility that supports the research efforts of over 1,500 laboratories at the University of Pennsylvania. We are not however a service or a core, we do not perform bioinformatics for fee, instead we conduct independent research on methods development and evaluation, and we collaborate on specific projects with select collaborators. We are particularly interested in all things transcriptomics, including data simulation. Our primary collaborators are in Pharmacology and Genetics, but we also collaborate with the biomedical community in general. Our postdocs should be oriented towards an academic career at the faculty level.
Last Application Date: Open Until Filled
26. Post doctoral fellow
Summary of Postdoctoral Fellowship:
Seeking a motivated curious individual to conduct research into the biological basis of fatigue. The experimental model systems we use include the nematode C. elegans and the mouse. Experience with these model systems is preferred. The projects in the lab are funded by the NIH and by the DOD.
Last Application Date: Open Until Filled
27. Postdoctoral Position in Tumor & Radiation Oncology
Summary of Postdoctoral Fellowship:
The Koumenis and Minn labs in the Department of Radiation Oncology at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, PA seek qualified and self-motivated candidates for a joint Postdoctoral Fellow position available immediately to study the molecular mechanisms underlying an exciting new radiation modality (“FLASH radiotherapy”). Our groups are well funded by large NIH grant and Foundation grants and by industry sponsored agreements. The two labs are part of a large Research Division comprised of 10 faculty and is well integrated within the Abramson Cancer Center. There are ample opportunities for training and career development, including mentoring on grant writing, career advice, networking and attendance and presentations national and international scientific meetings and symposia. Former graduate students and postdoctoral fellows trained in our labs currently hold faculty positions in academia and scientist positions in industry and in government agencies. This appointment will be for a maximum of three (3) years pending satisfactory performance. Competitive salary and benefits will be provided.
Last Application Date: Open Until Filled
28. NIH/NIDA T32 Translational Addiction Research Fellowship Program at the University of Pennsylvania
Summary of Postdoctoral Fellowship:
Post-doctoral applications are invited for training in the NIH-NIDA T32 Translational Addiction Research Fellowship Program within the Department of Psychiatry at the University of Pennsylvania School of Medicine. The translational emphasis of the program is reflected both in the didactics and mentoring structure, with each trainee receiving exposure both to preclinical and clinical science in addiction. The addiction research laboratories at Penn offer a wide range of training opportunities, including: brain PET and MRI imaging of vulnerabilities to relapse (e.g. heightened limbic response to drug cues; impaired decision-making, etc.), human laboratory studies of candidate addiction medications and nutritional interventions, genetic and pharmacologic modulators in neuroimaging, brain measures as predictors of medication and treatment response, and clinical trials testing novel medications for cocaine, opiate, nicotine, and marijuana addictions.
Last Application Date: Open Until Filled
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29. Postdoctoral Fellow
Summary of Postdoctoral Fellowship:
Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels and CALHM ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania. Our focus is on the molecular physiologies of three ion channel families, and their roles in physiology, including bioenergetics, cancer, neurodegeneration and sensory perception. Our research on the IP3R Ca2+ release channel and the mitochondrial Ca2+ uniporter seeks to understand the molecular determinants and physiological functions of endoplasmic reticulum-to-mitochondria Ca2+ transfer. Our research on CALHM ion channels centers on their roles in taste perception and the elucidation of the functional roles of different CALHM family members. Projects are available to investigate many aspects of channel biophysics, Ca2+ signaling, structural biology, and animal models.
Last Application Date: Open Until Filled
30. Special Postdoctoral Fellowship – Translational Research Gene Therapy
Summary of Postdoctoral Fellowship:
Muscle and cardiovascular biology postdoctoral fellowship positions are immediately available in the laboratory of Hansell Stedman, MD, FACS, Department of Surgery, Penn Cardiovascular Institute and Pennsylvania Muscle Institute. The main goals are to improve the understanding of the biomechanics of dystrophin and to use novel insights in the development of safe and effective gene therapy for dystrophin-deficient cardiomyopathy and respiratory failure, with the ultimate goal of clinical translation in Duchenne Muscular Dystrophy. We are using complementary approaches to the rational design of next generation vectors to address the shortcomings of candidate therapies tested in recent clinical trials. The proposed projects offer exceptional career growth opportunities for highly motivated candidates seeking to build on a solid foundation of doctoral work in the fields of neuromuscular disease, cardiovascular physiology, molecular/structural biology, immunology, and/or virology. We seek applicants with strongly supportive references and a track record of primary authorship.
Last Application Date: Open Until Filled
31. Postdoc in computational and systems biology
Summary of Postdoctoral Fellowship:
The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania. The postdoctoral fellow will be responsible for development of novel computational algorithms and/or experimental approaches to understand gene regulation in normal and cancer development.
Last Application Date: Open Until Filled
32. Postdoctoral Fellow in iPSC Hematopoiesis Models
Summary of Postdoctoral Fellowship:
The Thom lab is an integrated team of computational and basic scientists studying genetic determinants of hematopoiesis (blood cell formation), with a focus on megakaryocyte and platelet development. We employ induced pluripotent stem cell (iPSC) and murine models to study hematopoietic development. We have an open postdoctoral fellowship position to study the role of tropomyosins during in vitro hematopoiesis. The ideal candidate will have a PhD, MD, or both, with experience using in vitro stem cell models. Additional experience with molecular biology, flow cytometry, genomics, and imaging modalities are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.
Last Application Date: Open Until Filled
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33. Postdoc in single-cell cancer genomics
Summary of Postdoctoral Fellowship:
We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative (https://humantumoratlas.org/). The project provides an excellent training opportunity in single cell biology and cancer biology.
Last Application Date: Open Until Filled
34. Postdoctoral Fellow in Neonatalogy/ Hematopoiesis
Summary of Postdoctoral Fellowship:
The Thom lab is an integrated team of computational and basic scientists studying genetic determinants of hematopoiesis (blood cell formation), with a focus on megakaryocyte and platelet development. We employ induced pluripotent stem cell (iPSC) and murine models to study hematopoietic development. We have an open postdoctoral fellowship position to study the role of actin regulatory molecules during murine hematopoiesis. The ideal candidate will have a PhD, MD, or both, with experience using in vivo murine models. Additional experience with molecular biology, flow cytometry, and imaging modalities are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.
Last Application Date: Open Until Filled
35. Postdoc –CRISPR screen in hematopoietic stem cells to study ribosome biogenesis /ubiquitin signaling
Summary of Postdoctoral Fellowship:
A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.
Last Application Date: Open Until Filled
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36. Postdoctoral Fellowship Opening in Alzheimer’s Disease Genetics
Summary of Postdoctoral Fellowship:
We are seeking applications for postdoctoral researchers to work on any of the following areas: 1. Rare variant discovery in diverse, multi-ancestry datasets using genome-wide genotyping, whole-exome sequencing (WES), and whole-genome sequencing (WGS) data focusing on genome-wide association (GWA) analysis for identifying risk-increasing and protective variants for Alzheimer’s disease (AD), AD-Related Dementias (ADRDs) and other neurodegenerative diseases and disorders. This work will include developing and applying optimal analytic strategies accounting for global and local admixture in subjects of diverse ancestral backgrounds, and will benefit from experience with large datasets and cloud usage.
Last Application Date: Open Until Filled
37. Postdoctoral position in genetic and epigenetic of neurodevelopmental disorders
Summary of Postdoctoral Fellowship:
The Akizu lab seeks candidates for a Postdoctoral position in genetic and epigenetic mechanisms of pediatric neurodevelopmental and neurodegenerative disorders. The ideal candidate must be highly motivated and creative with strong ability to design and carry out experiments with a high level of independence. The successful candidate will work full time in one of our projects while also collaborating with other lab members and investigators in our institution and will be encouraged to apply for postdoctoral and career development fellowships, present posters and talks in scientifically relevant conferences, and contribute to manuscript writing and submission.
Last Application Date: Open Until Filled
38. Regenerative Medicine in Hematology
Summary of Postdoctoral Fellowship:
A full-time postdoctoral position is available in the Chou Lab in the Division of Hematology at the Children’s Hospital of Philadelphia and the University of Pennsylvania for an NIH-funded project to study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine. Red blood cell (RBC) transfusion is one of the most common medical treatments, with over 10 million units transfused per year in the United States alone. There is a need for alternative sources of red cells for transfusion. In vitro generation of red cells is a major goal in the field of regenerative medicine but has been hampered by available methods and renewable cell sources for a sustainable supply. Moreover, the need for rare red cells for use as reagents to detect specific antibodies in transfused patients further fuels efforts for production of cultured red cells, especially those with “designer” red cell antigen phenotypes.
Last Application Date: Open Until Filled
39. Post-doctoral fellow at CNDR
Summary of Postdoctoral Fellowship:
Post-doctoral position is available at the Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania for a motivated scientist that assumes responsibility for ongoing research projects focused on understanding the pathogenic mechanism/s of TDP-43 aggregation in Frontotemporal Lobar Degeneration (FTLD-TDP), Amyotrophic Lateral Sclerosis (ALS), and age-related dementias (LATE). We are also interested in translating basic molecular and biochemical insights with the ultimate goal of identifying mechanisms and potential therapeutic targets that will help slow the progression of these diseases. Under the direction/guidance of Dr. Sílvia Porta, the post-doc experience will serve to extend, refine and enhance skills necessary for professional and career development, and it will enable the individual to broaden her/his scientific background by acquiring new research capabilities. It is expected that the post-doctoral fellow will conduct independent scholarly research and contribute directly to the overall research goals of the project and the research group.
Last Application Date: Open Until Filled
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40. Post Doc Fellow – Epigenetics
Summary of Postdoctoral Fellowship:
Post Doctoral Fellow positions are available in the laboratory of Dr. Jennifer Kalish, at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Penn). Our lab is part of the rich scientific environment on the CHOP/Penn campus that includes multiple areas of epigenetics, cancer, genetics, and molecular biology. We are located in the new Colket Translational Research Building as part of the Division of Human Genetics in the Department of Pediatrics and the Center for Childhood Cancer Research (CCCR). The lab is also part of the Penn Epigenetics program. The lab’s research focuses on the transition between normal growth, overgrowth and cancer using human-cell based model systems and patient samples to study epigenetic causes of abnormal growth and cancer. We are interested in the infection points between normal growth and the transition to cancer to understand how they reveal insights into fundamental epigenetic and cellular mechanisms. We are particularly interested in how cancer predisposition syndromes contribute to the genetic and epigenetic set up for cancer. The laboratory work is part of a larger translational research program in which patient samples and clinical data are collected through a patient registry.
Last Application Date: Open Until Filled
41. Postdoctoral Researcher in Pharmacoepidemiology
Summary of Postdoctoral Fellowship:
Dr. Sean Hennessy, a clinical pharmacist and pharmacoepidemiologist, is PI of a National Institute on Drug Abuse-funded study entitled “Drug-Drug Interactions Involving Methadone and Buprenorphine”. This study will: i) perform high-throughput physiologically-based pharmacokinetic screening to predict the degree to which two-drug and three-drug combinations that include methadone or buprenorphine increase biological exposure to those agents; ii) perform high-throughput pharmacoepidemiologic screening of two-drug and three-drug combinations that include methadone or buprenorphine with regard to rate of emergency department presentation or hospitalization for opioid overdose and poisoning, opioid adverse effects, and cardiac arrest; iii) convene an independent multidisciplinary Expert Panel to review screening results and prioritize potential drug interaction pairs and triads for further investigation; and iv) conduct a series of rigorous pharmacoepidemiologic studies to inform causal inferences and thereby generate clinically-actionable evidence on prioritized methadone and buprenorphine drug-drug interactions.
Last Application Date: Open Until Filled
