47 Postdoctoral Fellowships at University of Pennsylvania, Pennsylvania

Are you holding PhD degree and looking for Postdoctoral Fellowships? University of Pennsylvania, Pennsylvania, USA inviting application for multiple Postdoctoral Fellowships. University of Pennsylvania is one of the largest university in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.

University of Pennsylvania has huge a campus in Pennsylvania and widely known as for its contribution in top notch education and research. The contribution of University of Pennsylvania is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences, social sciences, humanities, psychology, education, architecture etc..

1. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position at The Center for Autism Research This adolescent-focused position will join a large-scale, multi-site study using computer vision and computational linguistics to develop novel measures of social communication and affect in ASD, anxiety, and depression. The position has a focus on clinical training in diagnostic, cognitive, and language assessment across a range of psychiatric presentations in adolescence, with the opportunity for research training in computational behavior analysis methods. While this position is research assessment-focused, there may also be minor rotations conducting assessments in other clinical settings such as the Regional Autism Center, or with treatment/intervention of children with ASD. Minor rotations will depend on the fellow’s training goals and rotation availability. In addition the fellow will participate in broader training and scholarly activities within CHOP and CAR (e.g., lab meetings, journal clubs, clinical group supervision, professional development seminars). Fellows may also be provided the opportunity to achieve research reliability on the ADOS-2, if not already reliable. While the emphasis of the adolescent position for this postdoctoral fellowship is on clinical training and acquiring supervised clinical hours for licensure, there may be some opportunities to collaborate on ongoing research, depending on prior level of experience and interest. The expectation for this fellow will also be on clinical licensure (with licensure eligibility in the first year) and there may also be opportunities to provide training and supervision to graduate students, research assistants, and/or undergraduate students.

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position in exosomal proteins as biomarkers to predict treatment response is available immediately. The research will also investigate the role of exosomes in myeloproliferative neoplasms using state-of-the-art technologies at the University of Pennsylvania. The postdoc will also have opportunities to work with a pharmaceutical company. Training will be provided.

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Training Program Summary: Neuroimaging has become a leading strategy used for translational research in Alzheimer’s disease and related dementias (ADRD), as well as a prominent biomarker strategy for defining preclinical stages of ADRD, for clinical differential diagnosis of ADRD, and for evaluating for target engagement and therapeutic responses in clinical trials. Modern neuroimaging is an inherently interdisciplinary field combining expertise in neuroscience, biostatistics, and bioengineering. Additional expertise in topics such as genomics and basic science disease mechanisms are also required to translate neuroimaging in ADRD research. This proposed cross-disciplinary training program will provide two years of support for predoctoral and postdoctoral trainees from both biological and quantitative science backgrounds with the training required to develop a research career focusing on neuroimaging in ADRD. A core course curriculum will cover neuroimaging methods and additionally include specialized training in the Responsible Conduct of Research, Experimental Rigor, and Transparency and its application to neuroimaging.

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The University of Pennsylvania (UPenn) Frontotemporal Degeneration Center (FTDC) is currently seeking a qualified applicant for a postdoctoral fellowship. The overall mission of the Penn FTDC is to use integrative strategies to leverage multimodal data such as neuropyscholgical, neuroimaging and biofluid biomarker data to improve our understanding of the biological basis and heterogeneity of neurodegenerative conditions. We aim to identify environmental, lifestyle and genetic associations that can be used to understand variability in cognitive decline, uncover mechanisms of disease and/or stratify diverse patients to define homogenous patient groups with a higher likelihood of achieving a therapeutic response. We primarily focus young-onset neurodegentiave conditions such as frontotemporal lobar degeneration (FTLD). The Penn FTDC is a highly interdisciplinary environment based in the Neurology Department of the Perelman School of Medicine at the University of Pennsylvania. We work closely with clinicians in the NIA-funded Alzheimer Disease Center (ADC) and Comprehensive ALS Clinic as well as several national and international consortia. Our lab is also integrated into the FTDC and associated research centers at the University of Pennsylvania including the Penn Institue on Aging (IOA), Center for Neurodegenerative Disease Research (CNDR), Penn Neurodegeneration of Genomics Center (PNGC), Penn Image Computing Science Laboratory (PICSL), Institute for Translational Medicine and Therapeutics (ITMAT), Neuroscience Graduate Group and many others.

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5. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Penn Image Computing and Science Laboratory (PICSL) and the Penn Alzheimer’s Disease Research Center (ADRC) are seeking to recruit a postdoctoral fellow to engage in computational image analysis research focused on studying variability of imaging-based biomarkers of Alzheimer’s disease. The postdoctoral fellow will be working with ADRC faculty to analyze unique in vivo and postmortem imaging datasets using novel image registration, segmenta-tion, morphometry, and machine learning techniques. Candidates should have completed (or be about to complete) a Ph.D. in a relevant field of study and have a strong interest in neurodegenerative disease research.

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellowship position is available at Perelman School of Medicine, University of Pennsylvania for joint projects on cardiac repair in ischemic heart disease. We aim at understanding the molecular mechanisms underlying vascular dysfunction after myocardial infarction with a focus on endothelial cell plasticity and metabolism. The goal of this study is to develop new regenerative therapeutics by targeting vascular aberrancy and reprogramming vascular niche to promote cardiac repair after myocardial infarction (Nature Cardiovasc Res 2022). We are also interested in cell therapy for cardiovascular disease by targeting macrophages or fibroblasts using CAR-T immunotherapy, a promising strategy that our laboratories have developed for treating cancer (Nature Cancer 2021).

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Bradbury Lab in the Department of Medicine, Division of Hematology-Oncology and the Department of Medical Ethics and Health Policy at the University of Pennsylvania is recruiting a highly motivated postdoctoral research fellow with expertise in patient-oriented and behavioral research. Position is initially offered for one year – and can be extended up to at least three years contingent upon outstanding performance and program funding. Candidate can begin as early as January 2022. Available project within the Bradbury lab include several NIH funded translational genetic research studies focused on the clinical implementation of genetic medicine to promote the health of individuals, families and communities.

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Morrisey Lab is an integrated team of postdoctoral fellows, physician-scientists, students, and researchers whose goal is to better understand the cellular and molecular etiology of lung disease and regeneration. We have an open postdoctoral fellowship position to study lung regeneration. The ideal candidate will have a Ph.D., M.D., or both with experience in genetic models of stem/progenitor cell development and activation after injury. Additional experience in organoid modeling of stem cell behavior, single cell genomic analysis, and imaging are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is available in the laboratory of Dr. Jianxin You at the University of Pennsylvania Perelman School of Medicine. The laboratory is developing nanotechnology-based immunotherapy for eliciting antiviral and antitumor immunity (Proc Natl Acad Sci U S A. 2020;117:13730-13739). We also investigate how the molecular interplay between oncogenic viruses and their host cells leads to cancer (Cell 117:349-360, Cell Host Microbe 19:775-87). We are seeking an enthusiastic and highly motivated Postdoctoral fellow to join our effort in building innovative therapeutic strategies for blocking pathogenic viral infection and tumor development.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

The Brady lab led by Dr. Donita Brady is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. We are currently recruiting three postdoctoral fellows to join our research program at Penn. Our research program at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas. Our focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development. The emergence of this new paradigm in nutrient sensing and protein regulation has established that Cu is a critical mediator of intracellular signaling, provided evidence for the existence of molecular mechanisms for sensing changes in Cu abundance, and expanded the contribution of Cu to cellular processes necessary for adaptation to nutrient scarcity. This new signaling paradigm can be exploited as a unique, alternative approach to target the clinically validated activity of MEK1 and MEK2 by repurposing Cu chelators, used to combat high Cu levels in Wilson disease patients, to treat cancers with aberrant MAPK signaling.

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

Postdoctoral and research associate positions are available immediately to develop novel cancer immunotherapy, i.e. chimeric antigen receptor (CAR)-expressing T cells, to eradicate human neuroendocrine tumors (NETs) and gastrointestinal cancers as well as acute myeloid leukemia (AML), and investigate the unique molecular mechanisms on how CAR constructs, including the binders and the signaling domains, improve the T cell antitumor activity to eliminate solid tumors. These positions require experience in molecular cell biology or immunology and ideally experience with various mouse tumor models and flow cytometry analysis. Experience in T cell biology is valuable. The candidates should have a Ph.D. or equivalent degree. Successful applicants will have rich opportunities to gain a broad range of cutting-edge knowledge and experience ranging from synthetic biology, genome wide CRISPRa screening, immunology, bioinformatics, immunotherapy models as well as bench side to bedside translational studies. They will have opportunities to write grant proposal and enjoy a vibrant and highly interactive environment integrating cancer biology, immunology, translational immunotherapy ongoing at Penn campus that promote their career advancement.

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12. Two Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. Our lab is interested in cancer, stemness, and neurodegeneration. The current projects focus on two areas: (1) The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed an important role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. Furthermore, we are identifying and characterizing metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells. (2) Protein quality control, aging, and neurodegeneration. Our lab recently identified two protein quality control (PQC) systems, which consist of tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins, respectively. Unlike canonical PQC systems, these new systems are independent of ATP. They are multifunctional and highly effective in suppressing protein misfolding and aggregation. We are investigating their mechanisms of action; their roles in aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and polyglutamine diseases; and their utility in treating these diseases.

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative (https://humantumoratlas.org/). The project provides an excellent training opportunity in single cell biology and cancer biology.

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Thom lab is an integrated team of computational and basic scientists studying genetic determinants of hematopoiesis (blood cell formation), with a focus on megakaryocyte and platelet development. We employ induced pluripotent stem cell (iPSC) and murine models to study hematopoietic development. We have an open postdoctoral fellowship position to study the role of actin regulatory molecules during murine hematopoiesis. The ideal candidate will have a PhD, MD, or both, with experience using in vivo murine models. Additional experience with molecular biology, flow cytometry, and imaging modalities are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.

Last Application Date: Open Until Filled

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15. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.

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16. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Fellow position is available at The Children’s Hospital of Philadelphia Research Institute. The successful candidate will be dedicated and motivated, have creative thinking skills and be a driver of her/his research. This is an exciting opportunity to work with a group of experts on computational genomics to improve algorithms and develop software tools for the long-read sequencing techniques. These technologies, such as Oxford Nanopore and Pacific BioSciences, have significant advantages over conventional short-read Illumina sequencing technologies. We are developing various deep neural network approaches to handle unique challenges in long-read sequencing data, to facilitate novel genetic discoveries and accelerate the implementation of precision medicine.

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17. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Division of Diagnostic Innovation in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania has an immediate opening for a post-doctoral fellow to pursue new and exciting research in human genetics. Our current work broadly involves multi-omic investigation of complex diseases using academic biobank data and is directly relevant to precision medicine. We are leading several genomics studies of diseases such as breast cancer, pregnancy related adverse outcomes and cardiometabolic diseases to name a few in large multi-omic datasets. The ideal candidate is expected to develop and apply statistical and machine learning approaches to extract Electronic Health Record (EHR) based phenotypes for multi-omics research to understand the patterns of disease heritability and comorbidities. The candidate will be supported by a strong collaborative team who are world-known experts in EHR, multimodal imaging and genomics for complex diseases research and will provide access to the large -sample EHR, imaging and genetics data (Whole exome sequence and SNP array) from datasets such as Penn Medicine Biobank (PMBB), UKBiobank, eMERGE consortium and Million Veterans Program.

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

A post-doctoral position in human genetics and genomics is immediately available. Research in our group focuses on the development of genomics and bioinformatics methods to analyze sequencing data, and to enable the implementation of genomic medicine in clinical settings. The successful candidate will work on developing novel genomic methods to study human diseases that are related to genomic repeats. Example projects include the use of Illumina sequencing, optical mapping or long-read sequencing to assay human genomes, transcriptomes and epigenomes from patients with undiagnosed diseases, and to understand how repetitive elements and structural variants in complex genomic regions cause human diseases. More information about current research can be found at https://wglab.org. Depending on the candidate’s qualification and preference, Research Associate position instead of Postdoctoral position can also be offered.

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking applications for postdoctoral researchers to work on any of the following areas: 1. Rare variant discovery in diverse, multi-ancestry datasets using genome-wide genotyping, whole-exome sequencing (WES), and whole-genome sequencing (WGS) data focusing on genome-wide association (GWA) analysis for identifying risk-increasing and protective variants for Alzheimer’s disease (AD), AD-Related Dementias (ADRDs) and other neurodegenerative diseases and disorders. This work will include developing and applying optimal analytic strategies accounting for global and local admixture in subjects of diverse ancestral backgrounds, and will benefit from experience with large datasets and cloud usage. 2. Algorithm development and analysis for quality control and association testing of whole-genome sequencing genotype data for AD, including processing and refining multi-allelic rare variant and X-chromosome variant data and identifying novel susceptibility loci for dementia 3. Identification of pleiotropic genetic associations in GWA analyses of AD and related neurodegenerative diseases with an emphasis on data management, analysis, development of novel bioinformatics tools and methodologies for analysis of this data, implementation of complex pipelines, and interpretation and presentation of analysis results. This work will also include extensive processing of WGS and WES data on Alzheimer’s disease and other neurodegenerative disorders, using data processing and analytical pipelines and cloud computing.

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20. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Funding is available for a postdoctoral fellow to study taste receptor signaling in innate immunity, specifically how G-protein coupled taste receptors activate antimicrobial responses in immune cells. Our lab uses a combination of live-cell and confocal imaging, biochemistry, and molecular biology approaches using primary human cells isolated from nasal surgical samples and cultured at air-liquid interface. A main focus of our lab is bitter taste receptors, which are expressed in many tissues beyond just the tongue, where they serve largely unknown roles. In the airway, bitter taste receptors detect bacterial products and activate calcium-driven innate immune responses. In macrophages, bitter taste receptors regulate phagocytosis through calcium and NO signaling. The postdoc will work closely with the PI and other lab members and receive training in live-cell imaging and other techniques as needed, potentially including measurements of calcium, nitric oxide, pH, mitochondrial function, and/or imaging of fluorescent protein biosensors for calcium, cAMP or other signaling pathways.

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

Funding is available for a postdoctoral fellow to study epithelial signaling in innate immunity, specifically how G-protein coupled receptors activate antimicrobial responses in nasal and lung cells. Our lab uses a combination of live-cell and confocal imaging, biochemistry, and molecular biology approaches using primary human cells isolated from nasal surgical samples and cultured at air-liquid interface. A main focus of our lab is bitter taste receptors, which are expressed in many tissues beyond just the tongue, where they serve largely unknown roles. In the airway, bitter taste receptors detect bacterial products and activate calcium-driven innate immune responses. Our lab is located within the Division of Rhinology in the Department or Otorhinolaryngology. More about our lab’s research, equipment and resources, and recent publications by students and postdocs can be found at www.robleelab.com

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Baxter Lab in the Department of Orthopaedic Surgery at the University of Pennsylvania is seeking exceptional candidates to fill a postdoctoral research position to perform preclinical translational research. The Baxter lab (https://www.med.upenn.edu/orl/baxterlab/) is focused on improving rehabilitative care following soft-tissue injuries to restore functional outcomes. Our lab has NIH funded research projects using small animal models and patient cohorts to maximize our research impact on clinical care. This postdoctoral research opportunity will identify precision rehabilitation strategies that promote tendon healing and preserve skeletal muscle following Achilles tendon ruptures in an established rat model. This project has direct clinical translation and the successful candidate will work closely with our clinical collaborators to maximize the clinical impact of this research.

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Penn Medicine Center for Ophthalmic Genetics in Complex Diseases is seeking a postdoctoral researcher with a focus on bioinformatics. The mission of the Center is to elucidate the genetics of diseases that overaffect African ancestry population. Currently, a large focus of our lab is on glaucoma genetics. This candidate would help to complete the aims of the NIH-funded Primary Open-Angle African American Glaucoma Genetics (POAAGG) study, which has enrolled over 10,200 African ancestry individuals from Philadelphia. We have GWAS data on 7765 individuals, whole-exomes on 8500 individuals, and whole-genomes on 100 individuals. This candidate would lead bioinformatics analyses on this data, under the guidance of the PI and research directors with the opportunity to expand into other diseases in the future. The successful candidate will be dedicated and motivated, have creative thinking skills and be a driver of her/his research. This is an exciting opportunity to work with a group of experts on computational genomics, clinical experts and functional genomics to improve algorithms and develop software tools to better understand minority genetics.

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24. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Uyhazi and Bennett laboratories at the University of Pennsylvania are seeking a motivated postdoctoral fellow to join our team to investigate gene therapy and cell-based therapies for vision loss. Our goal is to use cutting-edge technology focused on photoreceptor regeneration to better understand the cellular and molecular biology of retinal degeneration and to develop novel therapies for blinding diseases. The ideal candidate will have a Ph.D., M.D., or both with experience in genetic mouse models, molecular biology, immunofluorescence staining, and microscopy. Additional experience in single cell data analysis, iPSC culture, and visual function testing is an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position for an MR physicist is available in the Division of Neuroradiology/Department of Radiology in the Cerebrovascular Lab (www.TheSongLabBrain.com) at the University of Pennsylvania. The position is to conduct research on multiplexed neuroimaging. We will use new deep learning-based processes that fuse multimodal images and create higher quality, data-rich medical images. Maximizing imaging data from each modality, we will then use machine learning to identify, validate and implement the use of neuroimaging biomarkers for neurologic disorders. This AI-fueled project will leverage the expertise of an interdisciplinary team to propel medical innovation towards more precise and personalized diagnostic strategies. The position requires focused expertise in the specific area of developing advanced MRI pulse sequences, image reconstruction/analysis methods and applying these techniques to neuroimaging for neurological disorders. These skills will be further supplemented with training in clinical translation and bioinformatics with the support of our interdisciplinary team of collaborating faculty at the University of Pennsylvania.

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Thom lab is an integrated team of computational and basic scientists studying genetic determinants of hematopoiesis (blood cell formation), with a focus on megakaryocyte and platelet development. We employ induced pluripotent stem cell (iPSC) and murine models to study hematopoietic development. We have an open postdoctoral fellowship position to study the role of tropomyosins during in vitro hematopoiesis. The ideal candidate will have a PhD, MD, or both, with experience using in vitro stem cell models. Additional experience with molecular biology, flow cytometry, genomics, and imaging modalities are an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The LiuLab utilizes modern cellular enzymology tools to investigate the functions of RNA modifying enzymes in cancer and neurological disorders. Additionally, our lab focuses on the contribution of sex chromosomes to sex bias in human disease. The ideal candidates with a strong background in either of the following areas including biochemistry, structural biology, bioinformatics, and molecular biology are encouraged to apply. Lab experience in one or more areas, including molecular cloning, protein purifications, mass spectrometry, RNA biochemistry, structural biology, and deep sequencing technologies, is highly desirable. As a private Ivy League research university, Penn offers a world-class environment for RNA biology and gene transcription regulation research. In an interdisciplinary collaborative research group, the successful candidate(s) will have access to state-of-the-art equipment and study modern RNA cellular enzymology and sex difference in gene regulation at the molecular level. Philadelphia is the sixth-most populous city in the United States, notable for its rich history and fun to live. A broad range of career advancement and specialized training opportunities is available on campus throughout the year. Numerous recreational activities are routinely organized at Penn.

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28. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The University of Pennsylvania Perelman School of Medicine Department of Anesthesiology and Critical Care in Philadelphia, Pennsylvania is seeking applications for a Postdoctoral Researcher. This position is funded by the National Institutes of Health, grant number 1R01HL153735-02. The goals of the 5-year (2020-2024) multicenter research study are to: 1) Ascertain determinants of operating room (OR) to intensive care unit (ICU) handoff protocol adoption and use in 12 adult and pediatric ICUs in five health systems, 2) Adapt OR to ICU handoff protocols using engineering approaches and select tailored implementation strategies, 3) Test the effectiveness of tailored, multifaceted, multilevel implementation strategies, and 4) Design and create a digital toolkit for other ICUs to identify implementation determinants, customize an OR-to-ICU handoff protocol, and select appropriate implementation strategies.

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29. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a creative and interactive individual to join our group as a postdoctoral fellow to play an integral role in the establishment of a new wildlife health initiative at Penn Vet, the Wildlife Futures Program (WFP). The postdoctoral fellow to investigate zoonotic diseases and/or disease spillover among animal species. This is an exciting and unique position with considerable flexibility to develop projects and conduct work related to the applicant’s area of interest. However, we anticipate the postdoc will contribute to existing projects on SARS-CoV-2 in wild and domestic animals. The ideal candidate will have expertise in some aspects of molecular virology and/or using viral sequence data in phylodynamic models. Publication of collaborative research findings in peer-reviewed journals and representing the Wildlife Futures Program at professional meetings and trainings will all be expected. The work will be conducted under the guidance of Drs. Roderick (Erick) Gagne and Julie Ellis, wildlife disease ecologists.

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30. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Bhoj Laboratory, a member of Penn’s Center of Cellular Immunotherapies (CCI), is looking for postdoctoral candidates interested in translational research focused on development of novel T cell immunotherapies. The over goal of the lab is to develop of CAR T cells and other platforms of engineered T cell-based immunotherapies for the treatment of diseases or conditions that are driven by pathogenic immune responses. The overarching premise is centered on the notion that T cell therapies offer several advantages in regard to target cell elimination and immunomodulation where traditional pharmacologic therapies fall short. Existing projects are focused on targeting B cells, plasma cells and T cells that drive autoimmune responses as well as allo-immune responses (e.g. anti-drug antibodies and organ/tissue allograft rejection. Several projects synergistically combine engineered T cell platforms with other biologicals or targeted small molecules for enhanced immune-modulation. Through highly collaborative efforts with academic and industry partners, projects span studies in rodent and NHP models as well as in humans in the form of active clinical trials and correlative studies using patient samples.

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Multiple postdoctoral fellows with terminal degrees (PhD, MD, DVM, etc.) are sought to conduct basic/translational research aimed at elucidating the role of aberrant mRNA splicing in generating targetable neo-epitopes in pediatric cancers. This project is funded through the National Cancer Institute’s Pediatric Immunotherapy Discovery & Development Network (PI-DDN) and several large private foundation grants. Research will be carried out under the guidance of Dr. Andrei Thomas-Tikhonenko, Professor of Pathology & Laboratory Medicine at Penn and Children’s Hospital of Philadelphia (CHOP). Applicants focusing on genomics, bioinformatics, and/or CompBio could be co-mentored by Dr. Yoseph Barash, Associate Professor of Genetics and Computer Science (https://www.biociphers.org/)

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32. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The postdoctoral researcher will primarily work on the following pharmacoepidemiology-focused studies, each led by a faculty member in the Division of Epidemiology. Dr. Sean Hennessy, a clinical pharmacist and pharmacoepidemiologist, is PI of a National Institute on Drug Abuse-funded study entitled “Drug-Drug Interactions Involving Methadone and Buprenorphine”. This study will: i) perform high-throughput physiologically-based pharmacokinetic screening to predict the degree to which two-drug and three-drug combinations that include methadone or buprenorphine increase biological exposure to those agents; ii) perform high-throughput pharmacoepidemiologic screening of two-drug and three-drug combinations that include methadone or buprenorphine with regard to rate of emergency department presentation or hospitalization for opioid overdose and poisoning, opioid adverse effects, and cardiac arrest; iii) convene an independent multidisciplinary.

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33. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Anafi lab is looking to recruit a postdoctoral fellow. The lab is based in the Department of Medicine and is part of the Penn Institute for Biomedical Informatics and the Chronobiology and Sleep Institute. The lab focuses on understanding the influence of sleep and circadian rhythms on physiology and disease using techniques from engineering, bioinformatics, and machine learning. Ongoing, NIH funded projects are concentrated on understanding circadian pathways in cancer and neurodegeneration. Collaborative projects combine computational analysis with experiments to identify new diagnostic tools and/or rational targets for chronotherapy.

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34. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A full-time postdoctoral position is available in the Chou Lab in the Division of Hematology at the Children’s Hospital of Philadelphia and the University of Pennsylvania for an NIH-funded project to study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine. Red blood cell (RBC) transfusion is one of the most common medical treatments, with over 10 million units transfused per year in the United States alone. There is a need for alternative sources of red cells for transfusion. In vitro generation of red cells is a major goal in the field of regenerative medicine but has been hampered by available methods and renewable cell sources for a sustainable supply. Moreover, the need for rare red cells for use as reagents to detect specific antibodies in transfused patients further fuels efforts for production of cultured red cells, especially those with “designer” red cell antigen phenotypes. The Chou lab has generated specialized human induced pluripotent stem cells (iPSCs) by reprogramming rare donor cells or by gene editing, and produced a renewable source of red blood cells (RBCs) with unique phenotypes, referred to as iRBCs.

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35. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in Dr. Krithika Lingappan’s laboratory at the division of Neonatology, Department of Pediatrics at Children’s Hospital of Philadelphia. We are funded by the NIH to look into molecular mechanisms behind sex-specific differences in lung development and lung injury and Endo-MT (endothelial to mesenchymal transition). We are specifically interested in the pulmonary endothelium, cell-cell and cell-ECM interactions in the lung microenvironment.We will tailor the post-doctoral period with the career goals of the applicant in mind and will provide guidance and mentoring for the same.

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36. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Akizu lab seeks candidates for a Postdoctoral position in genetic and epigenetic mechanisms of pediatric neurodevelopmental and neurodegenerative disorders. The ideal candidate must be highly motivated and creative with strong ability to design and carry out experiments with a high level of independence. The successful candidate will work full time in one of our projects while also collaborating with other lab members and investigators in our institution and will be encouraged to apply for postdoctoral and career development fellowships, present posters and talks in scientifically relevant conferences, and contribute to manuscript writing and submission. Our lab studies genetic and epigenetic mechanisms that perturb neuronal development, function or survival in pediatric neurodegenerative diseases, with the ultimate goal to uncover therapeutic strategies. Our work begins when we identify the genetic causes of a disease. We then development human pluripotent stem cell and animal models to study pathogenic mechanisms of the disease and to test therapeutic approaches. Experimental approaches that we use in our studies include the latest histology, cellular and molecular biology methods, and the most novel gene editing, metabolomic, proteomics and genomics approaches.

Last Application Date: Open Until Filled

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37. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Tishkoff lab integrates genomic, transcriptomic, metagenomic, metabolomic, and epigenomic datasets generated from a large sample of ethnically diverse Africans, African Americans, and African immigrants in the US (http://www.med.upenn.edu/tishkoff/). We use evolutionary, statistical, population genetics and functional genomics approaches to understand the genetic architecture of a number of anthropometric, cardiovascular, metabolic, and immune related traits for which we have detailed phenotype data. We are seeking postdocs focused on computational biology, functional genomics and/or single cell studies of immune response. The candidate for the computational position will be involved in inferring the demographic history of African populations, determining the genetic basis of adaptation during human evolutionary history, characterizing genetic and epigenetic factors influencing gene regulation in tissues and single cells in humans, characterizing variation from whole genome short and long-read sequencing data, and/or studying genotype/phenotype associations for complex traits.

Last Application Date: Open Until Filled

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38. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The ITMAT Bioinformatics Laboratory is a bioinformatics research facility that supports the research efforts of over 1,500 laboratories at the University of Pennsylvania. We are not however a service or a core, we do not perform bioinformatics for fee, instead we conduct independent research on methods development and evaluation, and we collaborate on specific projects with select collaborators.

Last Application Date: Open Until Filled

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39. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Drapkin Laboratory at the University of Pennsylvania is a dynamic and fun-loving group of curious and inspired scientists seeking to attract new members to the group. Our laboratory focuses on developing a comprehensive understanding of the genetic, molecular and physiological factors that drive the development of ovarian cancer. Work from the lab has implicated the fallopian tube (FT) secretory cell as the likely cell-of-origin for a majority of ovarian carcinomas and the lab has been at the forefront in developing novel experimental platforms that address the role of the FT epithelium and its susceptibility to neoplastic transformation. The lab is currently focused on utilizing these models to interrogate how genetic and epigenetic alterations influence lineage dependencies, genomic instability, tumor metabolism, and the tumor microenvironment.

Last Application Date: Open Until Filled

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40. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Researcher position is available for highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focus is understanding resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), understanding how to sequence DDRi with Immuno-Oncology (IO) drugs, and identifying biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX), patient derived organoid, and primary tumor cultures from ovarian and endometrial cancers. These PDX models minic the original tumor, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer creating an autologous in vivo model system. Our laboratory has close collaborations with pharmaceutical companies including AstraZeneca, Merck, REPAIR, InstilBio.

Last Application Date: Open Until Filled

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41. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Beltran lab within the Division of Experimental Retinal Therapies, School of Veterinary Medicine, at the University of Pennsylvania is seeking exceptional candidates for a Postdoctoral fellowship in the field of neuroinflammation. Gene therapies for many different retinopathies have taken center stage in recent years with one FDA approved gene therapy in the market and over 30 other retinal gene therapies in clinical trials. Concern has also grown for gene therapy associated inflammation and its impact on long-term patient outcomes. This research project will focus on an in-depth understanding of AAV-mediated inflammation pathways and immune responses in large animal models and development of targeted mitigation strategies to reduce the possibility of persistent chronic inflammation post retinal gene therapy administration. Using transcriptomic and proteomic approaches, the goal will be to differentiate the pathways and molecules involved in disease-associated chronic retinal inflammation observed in most retinopathies, and those emerging post-gene therapy.

Last Application Date: Open Until Filled

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42. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Modzelewski Lab (ModzLab) at the University of Pennsylvania Department of Biomedical Sciences School of Veterinary Medicine is recruiting a Postdoctoral Researcher and Data Scientist (Research Specialist) to join an exciting new NIH-NICHD funded project. Our work focuses on the emerging role of retrotransposons in early development and disease using mouse as a model system along with comparative biology using various mammalian species to learn about human health and reproduction.

Last Application Date: Open Until Filled

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43. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Postdoctoral fellow and research scientist positions are immediately available at University of Pennsylvania, School of Dental Medicine in Dr. Esra Sahingur’s laboratory. The primary focus of the laboratory is to determine the key regulators of inflammation in the maintenance of periodontal tissue homeostasis, epigenetic susceptibility to periodontal inflammation and periodontitis-associated systemic conditions. On-going projects include preclinical studies utilizing in vivo and in vitro disease models, and clinical translational projects which study: i) Innate sensing, ubiquitination and host-microbiome interactions in the oral cavity health and disease ii) The impact of aging on oral tissues iii) Interventions with natural compounds and small molecule inhibitors including nanoparticles iv) The link between oral and liver diseases

Last Application Date: Open Until Filled

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44. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral fellow position is available in a highly dynamic interdisciplinary laboratory studying the role of ciliary genes and signaling in bone development and diseases. Proposed studies focus on the role of ciliary genes in stem cell homeostasis and bone and cartilage development and diseases. Studies involve in vivo assessment cell lineage and stem cell commitment and bone cell activity using transgenic models. The successful candidate must be highly motivated with strong research capabilities and ability to design and carry out experiments with a high level of independence. This individual will also assist the PI in training new lab members and writing research manuscripts and documents.

Last Application Date: Open Until Filled

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45. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels and CALHM ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania. Our focus is on the molecular physiologies of three ion channel families, and their roles in physiology, including bioenergetics, cancer, neurodegeneration and sensory perception. Our research on the IP3R Ca2+ release channel and the mitochondrial Ca2+ uniporter seeks to understand the molecular determinants and physiological functions of endoplasmic reticulum-to-mitochondria Ca2+ transfer. Our research on CALHM ion channels centers on their roles in taste perception and the elucidation of the functional roles of different CALHM family members. Projects are available to investigate many aspects of channel biophysics, Ca2+ signaling, structural biology, and animal models.

Last Application Date: Open Until Filled

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46. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania.

Last Application Date: Open Until Filled

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