21 Postdoctoral Fellowships at University of Pennsylvania, Philadelphia

Are you holding PhD degree and looking for Postdoctoral Fellowships? University of Pennsylvania, Philadelphia, USA inviting application for multiple Postdoctoral Fellowships.

Academic life at Penn is unparalleled, with 134 countries and 50 U.S. states. Consistently ranked among the top 10 universities in the country, Penn enrolls 10,001 undergraduate students and welcomes an additional 16,746 students to our world-renowned graduate and professional schools. Penn’s award-winning educators and scholars encourage students to pursue inquiry and discovery, follow their passions, and address the world’s most challenging problems through an interdisciplinary approach.

1. Postdoctoral Researcher in Functional Genomics

Summary of Postdoctoral Fellowship:

The University of Pennsylvania Department of Ophthalmology is seeking a Postdoctoral Fellow for research on the pathobiology and genetic risk factors of primary open-angle glaucoma (POAG). The successful candidate will participate in a large NIH-funded study uniquely focused on identifying phenotypic and genetic variables associated with POAG in African Americans. POAG is the leading cause of irreversible blindness in the world today. This heterogeneous disease is known to manifest differently across and between genetic populations, yet most POAG research has focused exclusively on genes of European ancestry. POAG is five times more common and ten times more likely to cause blindness in African Americans compared to European Americans, and occurs earlier with more rapid progression in this over-affected population. Through the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study, we have collected DNA of over 10200 African Ancestry cases and controls in Philadelphia with over 90% of phenotypic and demographic information for cases. All cases and controls were recruited in Philadelphia and we have the participants approval to re- contact them for future studies. In analyzing this data, we aim to develop better-targeted treatment and diagnostic approaches for POAG, a devastating disease affecting many of our patients.

Last Application Date: Open Until Filled

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2. Postdoctoral Research Associate in epigenetic inheritance

Summary of Postdoctoral Fellowship:

The Lampson lab at the University of Pennsylvania (Department of Biology) seeks a postdoctoral associate for two complementary projects related to epigenetic inheritance through the mammalian germline. The first is a collaborative project to create synthetic mammalian artificial chromosomes, funded as an NIH Transformative Research Award. The second focuses on the centromeric histone variant CENP-A as a prototype for protein-encoded information transmitted between generations. Projects are multidisciplinary and take advantage of collaborations with synthetic biologists and structural biologists.

Last Application Date: Open Until Filled

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3. Postdoctoral Research Associate in Maternal and Child Health

Summary of Postdoctoral Fellowship:

Seeking a Predoctoral or Postdoctoral Fellow position with interest in Maternal and Child Health specifically around maternal morbidity and racial disparities. This position is funded through a grant from the American Heart Association to evaluation the implementation and effectiveness of a cardiovascular risk assessment algorithm for pregnant and postpartum patients in reducing maternal morbidity in the city of Philadelphia. The candidate would be working directly with Dr. Lisa Levine and the Maternal Fetal Medicine Research Program at Penn. Start date can be flexible but looking to fill as soon as possible. This position would be ideal for anyone with interest/experience in maternal child health, public health, reproductive epidemiology, implementation science, and/or disparity work. Fellow would be involved not only with the project occurring at Penn but will have opportunities to be involved with the entire Health Equity Research Network (HERN) that this grant is a part of (see below for links) along with the University of Alabama, The Ohio State, Northwestern, and UNC.

Last Application Date: Open Until Filled

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4. Postdoctoral Research Associate in Stem Cell Biology

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated individual for a postdoctoral position in the Gadue laboratory in the Center of Cellular and Molecular Therapeutics at the Children’s Hospital of Philadelphia. The Gadue laboratory focuses on using human ES and iPS cell models to study human pancreatic development and diabetes. The NIH funded position aims to study multiple forms of diabetes using genome engineered stem cell lines with a focus on endocrine lineage cells. Projects available include using the stem cell model to functionally validate variants discovered by genome wide association studies and their target genes in beta cell biology, especially in regard to cellular stress and how this relates to diabetes pathogenesis. In addition, projects on the study of monogenic forms of diabetes are also available, focusing on HNF1A and its downstream targets in endocrine cell development and function. Techniques used widely in the laboratory include CRISPR based genome engineering, stem cell culture, in vitro differentiation, flow cytometry, fluorescent microscopy and various genomic techniques (RNA-seq, ATAC-seq etc…). Prior experience in some of these areas while not required would be beneficial.

Last Application Date: Open Until Filled

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5. Postdoctoral Research Fellow in epigenetic mechanisms of neural developmental and disorders

Summary of Postdoctoral Fellowship:

The Akizu lab seeks candidates for a postdoctoral position in epigenetic mechanisms of neural developmental and disorders. The applicant must have a recent PhD in relevant fields, research experience in epigenomic (i.e. ChIPseq, Cut&Run, ATACseq, Hi-C…) OR human pluripotent stem cell culturing and organoid differentiation methods and at least one first author publication in an impactful scientific journal. The ideal candidate must be highly motivated and creative with strong ability to design and carry out experiments with a high level of independence. The successful candidate will work full time in one of our recently funded projects while also collaborating with other lab members and investigators in our institution. As part of career development training the candidate will be encouraged to apply for fellowships, present posters and talks in scientifically relevant conferences, and contribute to manuscript writing and submission.

Last Application Date: Open Until Filled

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

This is a rare opportunity to work on a translational research project involving both academia and industry over 3 years. The Raabe lab at the University of Pennsylvania and Glaxo Smith Kline (GSK) Research near King of Prussia (30 driving minutes from UPenn) have teamed up to focus on identification of NASH-related genes and isoforms amenable for RNA splicing modulation. The postdoc will characterize primary cells and organoids directly derived from the liver of NASH patients (PMID 33901295) using standard assays and ‘omics’-based approaches to identify candidate genes with nonsense-mediated RNA isoforms. This will be followed by target validation including genetic perturbation to identify prioritized targets for a subsequent screen to identify oligonucleotide hits for target up-regulation.

Last Application Date: Open Until Filled

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7. Postdoctoral Research Associate in retinal neuroinflammation

Summary of Postdoctoral Fellowship:

The Beltran lab within the Division of Experimental Retinal Therapies, School of Veterinary Medicine, at the University of Pennsylvania is seeking exceptional candidates for a Postdoctoral fellowship in the field of neuroinflammation. Gene therapies for many different retinopathies have taken center stage in recent years with one FDA approved gene therapy in the market and over 30 other retinal gene therapies in clinical trials. Concern has also grown for gene therapy associated inflammation and its impact on long-term patient outcomes. This research project will focus on an in-depth understanding of AAV-mediated inflammation pathways and immune responses in large animal models and development of targeted mitigation strategies to reduce the possibility of persistent chronic inflammation post retinal gene therapy administration. Using transcriptomic and proteomic approaches, the goal will be to differentiate the pathways and molecules involved in disease-associated chronic retinal inflammation observed in most retinopathies, and those emerging post-gene therapy.

Last Application Date: Open Until Filled

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Vining Lab at Penn Dental Medicine and Penn Engineering is seeking a highly motivated Postdoctoral Fellow who is interested in joining a multi-disciplinary team of scientists and engineers investigating mechanical regulation of inflammation in cancer and regeneration. The Fellow will have the opportunity to learn and develop new materials, cellular systems, and animal models for immuno-mechanical engineering. Penn Dental Medicine has a rich history as a research-intensive institution and continues to be an international leader in the generation of new knowledge and treatment modalities to improve oral health. Penn Dental Medicine unites basic scientists, clinicians, and engineers to translate new knowledge into clinical therapies that expand our understanding of oral diseases and advance patient care.

Last Application Date: Open Until Filled

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

One postdoctoral fellow position is available in the laboratory of Dr. Anh Le/Dr. Zhang. We are seeking a highly motivated, independent, and collaborative scientist to study immunoregulatory mechanisms under dental stem cell-based tissue regeneration or head & neck tumor microenvironment settings. The position is supported by federal and internal funding. There are multiple basic and translational research projects available for consideration. The laboratory is a highly collaborative and supportive training environment in which successful candidates will be given the opportunity to mentor and train junior lab members, develop new methodologies, and enhance professional development skills. The candidate’s responsibilities will include experimental design, execution, data analysis, data presentation, and manuscript preparation. The position is contingent on continued funding.

Last Application Date: Open Until Filled

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

One postdoctoral fellow position is available in the laboratory of Dr. Tizzano. The Tizzano’s lab is seeking a highly motivated, independent, and collaborative scientist with a focus on mucosal immunology, animal physiology, and/or in vitro imaging, that would be joining a multi-disciplinary team of scientists investigating mucosal inflammation, pathogen-host interactions, and physiology of immune responses. The position is supported by federal funding, and it is contingent on continued funding. There are multiple basic and translational research projects available for consideration. The laboratory is a highly collaborative and has a supportive training environment. Penn Dental Medicine has a rich history as a research-intensive institution that unites basic scientists, clinicians, and engineers to translate new knowledge into clinical therapies to improve health and well-being.

Last Application Date: Open Until Filled

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11. Postdoctoral Research Fellow in Machine Learning and Medical Image Analysis

Summary of Postdoctoral Fellowship:

The Department of Radiology at the University of Pennsylvania Perelman School of Medicine seeks candidates for postdoc fellow positions. The main focus of these positions is on the development of biomedical image analysis algorithms with an emphasis on advanced machine learning (deep learning) methods for MRI/CT/PET data analysis. Responsibilities include involvement in various imaging studies of Alzheimer’s disease, aging, brain development, and neuropsychiatric disorders and supervision of junior research investigators for developing algorithms of image segmentation and registration, time-series data modeling, and pattern recognition. The research will be conducted at the Research Laboratory for Machine Learning and Biomedical Data Analytics of the Center for Biomedical Image Computing and Analytics (CBICA), a dynamically growing medical image computing center, involving several laboratories and many collaborators from diverse fields.

Last Application Date: Open Until Filled

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12. Postdoctoral Research Associate in Psychiatric Genomics

Summary of Postdoctoral Fellowship:

An NIH funded postdoctoral position is available in the laboratory of Dr. Michael Gandal, MD PhD, which has recently relocated to the Departments of Psychiatry and Genetics at the University of Pennsylvania and the Lifespan Brain Institute at the Children’s Hospital of Philadelphia. The position is focused on the development and implementation of integrative genomic approaches to identify the target genes and biological effects of noncoding genetic variants conferring risk for neurodevelopmental and psychiatric disorders, such as autism, schizophrenia, and bipolar disorder. This work will leverage and extend several in-house large-scale brain genomics reference panels with integrated genotype and RNA-sequencing data from developing (n=700) and adult human brain samples (n>2000), generated as part of the PsychENCODE Consortium.

Last Application Date: Open Until Filled

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

This postdoctoral fellow will provide direct clinical services in the Pediatric Anxiety Treatment Center for Hall-Mercer (PATCH) program. Directed by Emily Becker-Haimes, PhD, PATCH represents a partnership between the Penn Center for Mental Health and Hall Mercer Community Mental Health and is embedded within the Child and Family Outpatient program at Hall-Mercer Community Mental Health/ The PATCH program treats youth with anxiety and obsessive-compulsive related disorders using a primarily exposure-based CBT model. PATCH is the only designated evidence-based practice center for exposure-based CBT for youth in the Philadelphia public mental health system (case mix is 75% Medicaid, 25% self-pay or private insurance). Primary activities for the fellow will include the provision of direct clinical services to youth between the ages of 4 and 18 seeking specialty treatment services for anxiety and obsessive-compulsive spectrum disorders. Specific clinical responsibilities include conducting intake evaluations and providing individual therapy.

Last Application Date: Open Until Filled

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The focus of the Neurodevelopment and Psychosis Research Training Program is to integrate basic and clinical neuroscience research in a cohesive effort to elucidate neural substrates of psychosis. Converging multidisciplinary approaches by collaborating laboratories at the University of Pennsylvania aim to contribute a new understanding of the symptoms, pathophysiology and etiology of psychosis. Research opportunities in animals and humans include the integration of neurobehavioral measures – cognition, emotion, olfaction – with neuroimaging, electrophysiological, cellular and molecular neuropathological measures. Genetic paradigms are pursued in examining endophenotypic markers and relevant disorders. A developmental perspective is an emphasis in human and animal studies. Trainees benefit from the rich and stimulating academic environment at Penn in pursuing innovative research in preparation for an academic career.

Last Application Date: Open Until Filled

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15. Postdoctoral Research Associate in molecular virology

Summary of Postdoctoral Fellowship:

An NIH-funded postdoctoral position is available in the laboratory of Elizabeth White, Ph.D. at the University of Pennsylvania Perelman School of Medicine. https://www.med.upenn.edu/whitelab/ Our collaborative team studies the molecular biology of human papillomaviruses (HPVs). Our goal is to understand the molecular mechanisms by which HPVs modulate host cell processes and cause cancer. Projects are available in several broad areas. We use molecular and cell biological techniques as well as computational biology, mass spectrometry, high-throughput screening approaches, and more to investigate HPV biology. For examples of our recent work, see PNAS (2019) 116:7033-7042 and eLife (2022) 11:e75466.

Last Application Date: Open Until Filled

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16. Epilepsy Research Fellowship

Summary of Postdoctoral Fellowship:

The laboratory of Ethan M. Goldberg is looking for a postdoctoral fellow who is interested in studying mechanisms of epilepsy in novel experimental models of severe childhood-onset genetic epilepsies. The position would involve studies that span a range of levels of analysis, from ion channels expressed in heterologous systems, to neurons and organoids derived from human embryonic stem cells, expression profiling, and/or studies in acute brain slices prepared from mice and imaging and electrophysiology in awake, behaving experimental animals. The laboratory uses ion channel, cellular, and synaptic neurophysiology; EEG; single-cell transcriptomics; opto- and chemicogenetics, and two-photon calcium imaging, in vitro and in vivo.

Last Application Date: Open Until Filled

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17. Postdoctoral Research Associate in Advanced Mechanics of 3-D Heart Tissues

Summary of Postdoctoral Fellowship:

To support ongoing extramurally-funded investigations, the Margulies Lab has an open postdoctoral position focused on myocardial disease modeling and preclinical therapeutic testing. Ongoing and planned research employs both ex-vivo human myocardial slices and 3-D engineered heart tissues to achieve unique synergies and cross-validation. Both platforms allow application of mechanical stress, rigorous mechanical testing, and live tissue imaging techniques. Target research themes include modeling genetic cardiomyopathies, microtubule-dependent regulation of mechanotransduction and contractility, ECM-cardiomyocyte interactions, and load-dependent remodeling of metabolic pathways. This position will utilize and develop expertise in cell biology, tissue engineering, imaging and preclinical pharmacology and provide opportunities for high-impact publications and collaborations with leading investigators within the UPenn Cardiovascular Institute.

Last Application Date: Open Until Filled

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18. Post-Doctoral Fellow in wildlife toxicology method development

Summary of Postdoctoral Fellowship:

We are seeking a creative and interactive individual to join our group as a postdoctoral fellow and play an integral role in the establishment of a new wildlife health initiative within Penn Vet’s Wildlife Futures Program (WFP). The successful candidate will work collaboratively with Pennsylvania Game Commission biologists, WFP and Pennsylvania Animal Diagnostic Laboratory System (PADLS) personnel at Penn Vet, and other partners to investigate the impacts of pesticide contaminants on Pennsylvania’s avian communities. Specific areas of focus will include, but not be limited to: 1) anticoagulant rodenticide exposure in barn owls (Tyto alba) and 2) evaluation of possible avian exposures to neonicotinoid insecticides in their environment.

Last Application Date: Open Until Filled

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Miner laboratory studies the role of cytosolic nucleic acid sensors in antiviral immunity and autoimmunity. We use rare disease research as a starting point to understand fundamental biological mechanisms. We have discovered several new mechanisms of autoimmunity, antiviral immunity, and autoinflammation. We have numerous animal models available in the laboratory. We are currently recruiting postdocs, who would join us to pursue projects related to either gene therapy, studies of endogenous retroviruses, autoimmunity, or microbiology.

Last Application Date: Open Until Filled

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20. Postdoctoral Research Associate in Cancer Cell Signaling and Chemical Biology

Summary of Postdoctoral Fellowship:

The Brady lab led by Dr. Donita Brady is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. We are currently recruiting three postdoctoral fellows to join our research program at Penn. Our research program at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas. Our focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development.

Last Application Date: Open Until Filled

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21. Postdoctoral Fellow in Cancer Cell Signaling and Metabolism

Summary of Postdoctoral Fellowship:

The Brady lab led by Dr. Donita Brady is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. We are currently recruiting three postdoctoral fellows to join our research program at Penn. Our research program at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas. Our focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development.

Last Application Date: Open Until Filled

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