37 Postdoctoral Fellowships at St. Jude Children’s Research Hospital, Tennessee

Are you holding PhD degree and looking for Postdoctoral Fellowships? St. Jude Children’s Research Hospital, Tennessee inviting application for multiple Postdoctoral Fellowships. St. Jude Children’s Research Hospital is one of the largest research center in the world with thousands of employees, students, and research scientists are involved in the innovation of science and technology daily.

St. Jude Children’s Research Hospital has huge a campus in Tennessee, USA and widely known as for its contribution in top notch education and research. The contribution of St. Jude Children’s Research Hospital, Tennessee is not only limited to natural sciences and engineering but it also offers high quality research as well as higher education in bio-medical sciences etc..

1. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.

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2. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are interested in identifying novel genes and genetic variants that contribute to development of cancer and primary immunodeficiency. In 2015, we and others identified germline variants in ETV6, the gene encoding the essential hematopoietic transcription factor ETV6, in families affected by autosomal dominant thrombocytopenia and predisposition to B-acute lymphoblastic leukemia (B-ALL). We are now using human and mouse models to decipher how these germline ETV6 variants impact hematopoiesis and promote leukemogenesis. Towards this end, we have generated a knock-in mouse model harboring a heterozygous germline Etv6 variant that mimics a human variant observed in multiple kindreds. We are characterizing the hematopoietic phenotypes of these animals and examining the transcriptional mechanisms by which ETV6 regulates these processes. To model these cell compartments and perform assays in vitro, we also employ a number of cell lines including murine-derived HSPCs and pro-B cells, as well as human iPSCs. To study the role of ETV6 in malignancy, we have crossed the Etv6 variant mice with other mouse strains carrying known cooperating events identified in leukemia samples. Ultimately, our goal is to better understand how germline and somatic genetic events perturb key cellular and molecular pathways that then lead to leukemia.

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3. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Dr. Kundu’s lab currently has an opening for a postdoctoral research fellow. The project will be to investigate the role of ulk1/2 in hematopoietic stem cells.

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4. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

St. Jude is highly motivated to develop a novel research program to acquire cognitive and psychosocial data pre- and post-cancer therapy, for characterizing and predicting the effect of cancer and cancer-therapy on sensory, perceptual, cognitive and emotional aspects of brain function and behavior, and for developing interventions with brain modulation and stimulation techniques to reverse the adverse cognitive effect of pediatric cancer. This new program would heavily rely on the application of multimodal functional brain imaging which requires highly sophisticated imaging techniques, such as functional magnetic resonance imaging (fMRI), functional Near Infrared Spectroscopy (fNIRS), electro/magnetoencephalography (EEG/MEG) and brain stimulation combined with novel experimental paradigms. In addition, novel computational neuroscience and artificial intelligence methods including functional and effective connectivity, causality modeling, real-time imaging, brain-computer interfaces and neurofeedback would be key tools for scientific investigation and translational intervention in this new research program.

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5. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship in the laboratory of Dr. Lillian Guenther in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Guenther’s research specifically focuses on identification of novel therapeutic targets in osteosarcoma. Dr. Guenther’s research has utilized genome-scale CRISPR screening and other complementary large-scale chemical and genomic screening modalities in multiple types of pre-clinical models to uncover novel dependencies, or critical osteosarcoma-specific survival genes. Research in the Guenther laboratory is designed to discover how such critical osteosarcoma dependency genes enable cell growth, with an eye towards clinical translation. We are specifically interested in enrichment for DNA damage repair and replication stress-related targets in this disease, and how this biology may be optimally exploited to better treat patients.

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6. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The Neumann lab is seeking candidates for a full-time postdoctoral research associate. The successful candidate will be responsible for developing novel imaging agents for use in Positron Emission Tomography (PET). Current projects in the Neumann lab focus on cancer, infectious disease, and oxidative stress imaging in various preclinical models. The ideal candidate should have a strong background in synthetic chemistry and radiochemistry, relevant cell culture training, some experience in small animal work, and an interest in in vivo imaging and translational science. The successful applicant will work as part of a collaborative team and will have access to a wide range of equipment, including a DOI PET/CT scanner, PET/MRI, focused ultrasound (FUS), on-site cyclotron, 18F and 11C synthesis modules, hot cells, liquid scintillation equipment, automated HPLCs and more. A dedicated cell and molecular biology laboratory, fully equipped for biological assays, will also be available. The candidate will also be cross-trained in Focused Ultrasound techniques to improve delivery of novel radiopharmaceuticals to the Central Nervous System.

Last Application Date: Open Until Filled

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7. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Postdoctoral positions are available in the McKinney-Freeman laboratory of the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study the fundamental biology of hematopoietic stem cells (HSCs). HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Our major goals are to 1) illuminate the intrinsic and extrinsic factors that control the ability of HSC to home to, engraft, and repopulate the hematopoietic compartment after transplantation, 2) better understand the development of the HSC pool and bone marrow niche during early life and 3) uncover how chronic hematologic disease corrupts HSCs, with a particular focus on Sickle Cell Disease. We hope to leverage this knowledge to design therapies targeted at improving HSC transplantation for hematologic disease and gene therapy, as well as illuminate mechanisms of hematopoietic failure during chronic hematologic disease.

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8. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive aspergillosis by identifying the molecular mechanisms underpinning antifungal resistance in the fungal pathogen Aspergillus fumigatus, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of A. fumigatus.

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9. Postdoctoral Research Fellowship

Summary of Postdoctoral Fellowship:

We are recruiting a postdoc for a structural biology project that investigates the role of water networks at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 4 years. We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. Despite the focus on computational structural biology, we will consider exceptional candidates with a suitable experimental background and a strong interest in protein dynamics, ligands and water.

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10. Postdoctoral Research Fellow Positions

Summary of Postdoctoral Fellowship:

The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children’s Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.

Last Application Date: Open Until Filled

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11. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

A postdoctoral position is available in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors. In this position, you will have a chance to lead your projects and mature into fully independent researcher. Successful candidate will gain an experience in genome wide technology, CRISPR-Cas editing, mouse models and stem cell biology.

Last Application Date: Open Until Filled

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12. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our recent findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.

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13. Postdoctoral Research Fellow

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Dr. Rohit Papu (Washington University in St. Louis).

Last Application Date: Open Until Filled

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14. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A Postdoctoral Research Associate position is open in the Li laboratory to study the dysregulated transcription dependency under the 3D chromatin niche in human cancers. Cutting-edge technologies and multidisciplinary approaches, including genetic and epigenomic CRISPR editing, comprehensive genetic screens, and the auxin-induced protein degradation system, are used to investigate the precise function of transcription factors and noncoding segments involved in gene transcription, chromatin architecture, and chromatin accessibility maintenance in pediatric leukemia. Those efforts are anticipated to shed light on understanding how gene regulation is precisely controlled in temporal and spatial gene expression in cancers and will provide insights into alternative therapy development. The candidate will be offered an excellent research environment to work on novel candidates identified from our own CRISPR screens and integrative analysis of multidimensional datasets.

Last Application Date: Open Until Filled

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15. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

The Mittag laboratory invites applications for a Postdoctoral Research Fellow position to work on in vitro biophysics studies of the biology and biophysics of RNP granules. We will be addressing the biophysical and biological consequences of the network structure underlying stress granules. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Rohit Pappu (Washington University in St. Louis). The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.

Last Application Date: Open Until Filled

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16. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

St. Jude is seeking an outstanding candidate for postdoctoral fellow in multi-omics research. As a fellow you will join Dr. Qian Li’s lab in the Department of Biostatistics, providing computational or statistical support and developing analytical methods at the cutting edge of omics studies. You will benefit from access to unique datasets and expertise; top-ranked scientific environment; and superb benefits, mentoring, and professional development. One position is available with an appointment of two years. Dr. Qian Li’s methodological research focuses on (temporal) omics data, such as transcriptomics, metagenomics, and metabolomics. This postdoctoral fellow will develop innovative methods and tools for large-scale omics data analysis, including the integration of multi-omics data, in pediatric catastrophic disease. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS), and the largest pediatric cancer genome database, St. Jude Cloud.

Last Application Date: Open Until Filled

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17. Postdoctoral Fellowship

Summary of Postdoctoral Fellowship:

St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes.

Last Application Date: Open Until Filled

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18. Post-Doctoral Fellow

Summary of Postdoctoral Fellowship:

The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.

Last Application Date: Open Until Filled

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19. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

Last Application Date: Open Until Filled

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20. Biodiversity Postdoctoral Fellowship

Summary of Postdoctoral Fellowship:

We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes. Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.

Last Application Date: Open Until Filled

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21. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A unique postdoctoral fellow position is available immediately in the joint laboratory of Dr. Christopher Tinkle, Department of Radiation Oncology, and Dr. Anang Shelat, Department of Chemical Biology and Therapeutics, to apply state-of-the-art chemical biology and bioinformatics methodologies across diverse pediatric malignancies to investigate the molecular consequences of defective DNA repair, and to target these deficits using small molecules. This project leverages the institution’s world class repository of patient derived xenograft models and associated genomic and proteomic data sets. This work will directly support the institution’s translational program, with the goal of identifying clinically actionable drug-drug and drug-radiation combination strategies.

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22. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children’s Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries. We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors.

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23. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021. The ideal candidate will demonstrate a willingness to learn new concepts and technical skills, but most importantly harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts. An ideal candidate will have a strong foundation in molecular biology-based techniques, experience/willingness to work with animal handling and procedures, and have a willingness to learn/work with complex computational software.

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24. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

The Bikoff lab (https://www.stjude.org/research/labs/bikoff-lab.html) is seeking a highly motivated postdoctoral researcher interested in studying neural circuitry in mice. The fundamental goal of our research is to understand how neural circuits control movement. We approach this from multiple perspectives, using cutting-edge technologies to analyze the molecular diversity of spinal interneurons, explore how descending systems in the brain convey information to the spinal motor system, and define the functional roles of spinal interneurons in generating behavior. These projects are highly multidisciplinary, taking advantage of a wide range of techniques including viral tracing, optogenetics and electrophysiology, whole-brain imaging, single-cell transcriptomics, and quantitative approaches to behavior. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, fun, and supportive environment that provides the freedom to independently develop a research project. The Bikoff lab is strongly committed to providing individual mentoring and training, as well as ongoing support at all stages of career development. Applications: Individuals with evidence of scientific accomplishment are encouraged to apply by sending their CV, a brief description of research interests, and contact information for three references to: jay.bikoff@stjude.org.

Last Application Date: Open Until Filled

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25. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

The department is seeking an outstanding postdoc fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer, mental health, and neurodegenerative diseases. Strong background in tensor analysis, functional data analysis, imaging data analysis, high dimensional data modeling, statistical learning, multivariate data analysis, survival data analysis, nonparametric statistics, statistical genetics, or deep learning are all considered as a plus. A recent Ph.D. in statistics, biostatistics, bioinformatics, computational biology, computer science or closely related field is required. Appointment is for two years. Applicants must have a strong computational background and demonstrate excellent written and verbal communication skills. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are very competitive. Send cover letter, CV, and three recommendation letters to Dr. Cai Li via e-mail at cai.li@stjude.org.

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26. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Outstanding candidates are invited to apply for a medical physics postdoctoral research associate in the Department of Radiation Oncology at St. Jude Children’s Research Hospital. In this two-year position, you will benefit from world-class resources and exceptional training in a top-ranked research environment while helping to advance treatment options for children with cancer.

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27. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are seeking two outstanding candidates for postdoctoral fellowship positions in the HPV Cancer Prevention Program at St. Jude Children’s Research Hospital. The postdoctoral positions offer an intensive, mentored training experience in implementation science, community-engaged research, health equity, and cancer prevention through HPV vaccination. Postdoctoral fellows will be encouraged to support the research foci of the HPV Cancer Prevention Program and develop their own research programs in implementation science with a specific focus on HPV vaccination or other related topics (e.g., health equity, partner and engaged research approaches, building vaccine confidence, supporting vaccinations in clinical and community settings, public policy and advocation, communications, etc.) using implementation science frameworks.

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28. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS).

Last Application Date: Open Until Filled

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29. Postdoctoral Fellow

Summary of Postdoctoral Fellowship:

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying a combination of innovative, multi-omic approaches to discover new biological, mechanistic, and clinical insights responsible for medulloblastoma initiation, progression, and relapse.

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30. Postdoctoral Researcher

Summary of Postdoctoral Fellowship:

A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic and epigenetic underpinnings of chemotherapeutic drug resistance and relapse in childhood leukemia.

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31. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective. Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration, and polarization.

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32. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.

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33. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome).

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34. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

We are recruiting a Postdoctoral Research Associate (a Cell and Molecular Biologist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The cell and molecular biology efforts are expected to synergize with our pharmacology, structural biology, and medicinal chemistry efforts and enable publication of impactful papers (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021; Nucleic Acids Res 50:3254, 2022). We work closely with the High Throughput Bioscience (HTB) Center (directed by Dr. Chen)

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35. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are competitive. Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.

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36. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity.

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37. Postdoctoral Research Associate

Summary of Postdoctoral Fellowship:

A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study.

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